Marine Bioactive Compounds with Neuroprotective Potential

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine Pharmacology".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 727

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Guest Editor
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch, Russian Academy of Sciences, 690022 Vladivostok, Russia
Interests: cells of the immune system; the molecular mechanism of action; membrane receptors; neurodegenerative disorders; cytoptotection; inflammation; new drug discovery
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Dear Colleagues,                

Neurodegenerative disorders are the second leading cause of death worldwide and the first leading cause of disability. The most common diseases affecting the brain are Alzheimer's disease (AD), Parkinson's disease (PD), and multiple sclerosis. Due to the high mortality and incidence of neurological disorders, preventive and therapeutic strategies are critical. Currently, no effective pharmacological treatment has been proposed that would block or treat the progression of neurodegenerative diseases. Conventional medications prescribed to treat neurological disorders are associated with various side effects; consequently, in recent years, many researchers have considered the possible therapeutic effects of natural products on neurological diseases. The search and development of new approaches and drugs for their treatment is an extremely urgent task. In recent years, natural compounds of marine origin have been of great interest for their structural diversity and wide range of biological activity. In addition to antioxidant, anti-inflammatory, antiproliferative, antidiabetic, and cardioprotective properties, biocompounds of a marine origin have also shown neuroprotective activity.

Thus, through the utilization of the biological functions of the most intensively studied biocompounds as potential drugs for neurodegenerative disorders, marine pharmacology is constantly proving its potential in the field of biomedicine.

This Special Issue is intended to present ongoing research into the neuroprotective properties of marine natural compounds. We particularly welcome papers evaluating the molecular mechanisms of action of marine-derived compounds and their analogues. Also of interest are works on the isolation and structure determination of new compounds of marine origin with neuroprotective activity in the latest in vitro and in vivo models in the field of neurodegenerative disease research.

Dr. Evgeny A. Pisliagin
Guest Editor

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Keywords

  • new drug discovery and development
  • neuroinflammation
  • neurodegenerative diseases
  • marine biologically active compounds
  • neuroprotection
  • central nervous system (CNS) disorders
  • Alzheimer’s disease (AD)
  • Parkinson’s disease (PD)
  • schizophrenia
  • dementia

Published Papers (1 paper)

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Research

13 pages, 9005 KiB  
Article
Porphyran Attenuates Neuronal Loss in the Hippocampal CA1 Subregion Induced by Ischemia and Reperfusion in Gerbils by Inhibiting NLRP3 Inflammasome-Mediated Neuroinflammation
by Dae Won Kim, Tae-Kyeong Lee, Ji Hyeon Ahn, Se-Ran Yang, Myoung Cheol Shin, Jun Hwi Cho, Moo-Ho Won, Il Jun Kang and Joon Ha Park
Mar. Drugs 2024, 22(4), 170; https://doi.org/10.3390/md22040170 - 11 Apr 2024
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Abstract
Porphyran, a sulfated polysaccharide found in various species of marine red algae, has been demonstrated to exhibit diverse bioactivities, including anti-inflammatory effects. However, the protective effects of porphyran against cerebral ischemia and reperfusion (IR) injury have not been investigated. The aim of this [...] Read more.
Porphyran, a sulfated polysaccharide found in various species of marine red algae, has been demonstrated to exhibit diverse bioactivities, including anti-inflammatory effects. However, the protective effects of porphyran against cerebral ischemia and reperfusion (IR) injury have not been investigated. The aim of this study was to examine the neuroprotective effects of porphyran against brain IR injury and its underlying mechanisms using a gerbil model of transient forebrain ischemia (IR in the forebrain), which results in pyramidal cell (principal neuron) loss in the cornu ammonis 1 (CA1) subregion of the hippocampus on day 4 after IR. Porphyran (25 and 50 mg/kg) was orally administered daily for one week prior to IR. Pretreatment with 50 mg/kg of porphyran, but not 25 mg/kg, significantly attenuated locomotor hyperactivity and protected pyramidal cells located in the CA1 area from IR injury. The pretreatment with 50 mg/kg of porphyran significantly suppressed the IR-induced activation and proliferation of microglia in the CA1 subregion. Additionally, the pretreatment significantly inhibited the overexpressions of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing protein-3 (NLRP3) inflammasome complex, and pro-inflammatory cytokines (interleukin 1 beta and interleukin 18) induced by IR in the CA1 subregion. Overall, our findings suggest that porphyran exerts neuroprotective effects against brain IR injury, potentially by reducing the reaction (activation) and proliferation of microglia and reducing NLRP3 inflammasome-mediated neuroinflammation. Full article
(This article belongs to the Special Issue Marine Bioactive Compounds with Neuroprotective Potential)
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