Functional Foods from Marine Bioresources: Recent Findings and Feasibility Study for Application

A special issue of Marine Drugs (ISSN 1660-3397). This special issue belongs to the section "Marine-Derived Ingredients for Drugs, Cosmeceuticals and Nutraceuticals".

Deadline for manuscript submissions: closed (30 November 2023) | Viewed by 2112

Special Issue Editor


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Guest Editor
Faculty of Fisheries Sciences, Hokkaido University, Minato 3, Hakodate, Hokkaido 041-8611, Japan
Interests: seafood; food function; health benefit; seafood by-products; seafood allergy

Special Issue Information

Dear Colleagues,

It is well-known that marine bioresources contain various functional components that have positive effects on human health, and proceedings of biochemical and separation technologies are expected for the effective use of new findings. This Special Issue welcomes reports on the latest findings on functional materials/components derived from marine bioresources and such as fish, invertebrates, and algae. Furthermore, the Special Issue expects introductions of technologies related to industrial applications; these feasibility studies are extremely important findings for the effective use of functional materials from marine bioresources and by-products. This Special Issue also welcomes reviews of a series of research results on specific functional materials and discussion on the scientific background of new technologies that have acquired industrial property rights.

Prof. Dr. Hiroki Saeki
Guest Editor

Manuscript Submission Information

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Keywords

  • marine bioresources
  • fish
  • shellfish
  • seaweed
  • health benefit
  • therapeutic effect
  • food application
  • separation science

Published Papers (1 paper)

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Research

20 pages, 11090 KiB  
Article
Antioxidant Peptides from Monkfish Swim Bladders: Ameliorating NAFLD In Vitro by Suppressing Lipid Accumulation and Oxidative Stress via Regulating AMPK/Nrf2 Pathway
by Ming-Feng Wu, Qing-Hao Xi, Yan Sheng, Yu-Mei Wang, Wan-Yi Wang, Chang-Feng Chi and Bin Wang
Mar. Drugs 2023, 21(6), 360; https://doi.org/10.3390/md21060360 - 16 Jun 2023
Cited by 35 | Viewed by 1745
Abstract
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on an FFA-induced NAFLD model of HepG2 cells. The lipid-lowering mechanisms revealed that these five oligopeptides can up-regulate the [...] Read more.
In this study, we investigate the ameliorating functions of QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) from monkfish swim bladders on an FFA-induced NAFLD model of HepG2 cells. The lipid-lowering mechanisms revealed that these five oligopeptides can up-regulate the expression of phospho-AMP-activated protein kinase (p-AMPK) proteins to inhibit the expression of the sterol regulatory element binding protein-1c (SREBP-1c) proteins on increasing lipid synthesis and up-regulating the expression of the PPAP-α and CPT-1 proteins on promoting the β-oxidation of fatty acids. Moreover, QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) can significantly inhibit reactive oxygen species’ (ROS) production, promote the activities of intracellular antioxidases (superoxide dismutase, SOD; glutathione peroxidase, GSH-PX; and catalase, CAT) and bring down the content of malondialdehyde (MDA) derived from lipid peroxidation. Further investigations revealed that the regulation of these five oligopeptides on oxidative stress was achieved through activating the nuclear factor erythroid 2-related factor 2 (Nrf2) pathway to raise the expression levels of the heme oxygenase 1 (HO-1) protein and downstream antioxidant proteases. Therefore, QDYD (MSP2), ARW (MSP8), DDGGK (MSP10), YPAGP (MSP13) and DPAGP (MSP18) could serve as candidate ingredients to develop functional products for treating NAFLD. Full article
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