Application of Magnetic Nanoparticles in Magnetic Hyperthermia and Magnetomechanical Stress

Dear Colleagues,

With the development of nanotechnology, the emergence of new antitumor techniques using magnetic nanoparticles such as magnetic hyperthermia and magnetomechanical activation have been the subject of much attention and study in recent years as anticancer tools. In magnetic hyperthermia, an external alternating magnetic field is used to heat the area of the cancer tissue due to the local heating of the magnetic nanoparticles, which are preferentially accumulated in cancer cells due to altered iron metabolism. This treatment leads to cellular effects such as decreased cell viability, cytoskeleton damage, elevation of oxidative stress, cell cycle arrest, and cellular death by apoptosis. By taking advantage of differences in the thermal resistance of normal and tumor cells, magnetic hyperthermia can kill tumor cells selectively, thus lowering the side effects.

A relatively new technique that has gained more and more popularity in recent years for the treatment of cancer is magnetomechanical stress. In this technique, the magnetic field exerts magnetic forces on the magnetic nanoparticles, which in turn exerts mechanical forces on malignant and non-malignant cell membranes, causing damage and cell death primarily to cancerous tissues.

This Special Issue will focus on current approaches in the use of magnetic nanoparticles, magnetic hyperthermia, and magnetomechanical stress in the search for a multifunctional therapy in cancer, with an improved therapeutic index of treatment without non-additive side effects on normal tissue.

Prof. Dr. Rumiana Tzoneva
Guest Editor

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