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Personalized Medicine of Digestive Diseases
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Personalized Medicine of Digestive Diseases

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Methodology, Drug and Device Discovery".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 2785

Special Issue Editor

Dr. Takashi Murakami

E-Mail Website
Guest Editor
Department of Gastroenterology, Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan
Interests: endoscopy; colorectal polyp; colorectal cancer; serrated lesion; gastrointestinal bleeding

Special Issue Information

Dear Colleagues, 

The Journal of Personalized Medicine is pleased to announce a Special Issue focused on digestive disease (DD)-related topics, including in the esophagus, stomach, small and large intestines, and rectum. This Special Issue aims to present the emerging studies and developments in DD diagnosis, management, and treatment. We are interested in articles that explore not only novel imaging techniques, endoscopic and surgical management, and systemic therapies, but also the pathophysiology, molecular biology, and gut microbiome of DD. We welcome original studies, clinical case reports (sample size no less than 10), and reviews from researchers, clinicians, and experts in the field. This Special Issue is an excellent opportunity to share your study with a broad audience of medical professionals and advance our understanding and treatment of DD.

Dr. Takashi Murakami
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • inflammatory bowel disease
  • irritable bowel syndrome
  • gastritis
  • constipation
  • bleeding
  • cancer
  • endoscopy
  • surgery
  • systemic therapy
  • imaging technique

Published Papers (1 paper)

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Research

12 pages, 425 KiB  
Article
The Association between Hormone Replacement Therapy and Gastroparesis in Post-Menopausal Women: A Worldwide Database Analysis
by Jacqueline Khalil, Hannah Hill, David Kaelber and Gengqing Song
J. Pers. Med. 2024, 14(3), 275; https://doi.org/10.3390/jpm14030275 - 29 Feb 2024
Viewed by 2500
Abstract
Female sex hormones have been hypothesized to influence the higher prevalence of gastroparesis in females. This study investigated the effects of hormone replacement therapy (HRT) on gastroparesis and its related symptoms, medication use, and diagnostic testing in post-menopausal women. Utilizing the TriNetX platform, [...] Read more.
Female sex hormones have been hypothesized to influence the higher prevalence of gastroparesis in females. This study investigated the effects of hormone replacement therapy (HRT) on gastroparesis and its related symptoms, medication use, and diagnostic testing in post-menopausal women. Utilizing the TriNetX platform, we conducted a population-based cohort study involving post-menopausal women aged 50 or older, with and without HRT. One-to-one propensity score matching was performed to adjust for age, race, ethnicity, diabetes, body mass index (BMI), and hemoglobin A1c. The exclusion criteria included functional dyspepsia, cyclic vomiting syndrome, and surgical procedures. After applying the exclusion criteria, we identified 78,192 post-menopausal women prescribed HRT and 1,604,822 not prescribed HRT. Post-propensity matching, each cohort comprised 67,874 patients. A total of 210 of the post-menopausal women prescribed HRT developed an ICD encounter diagnosis of gastroparesis at least 30 days after being prescribed HRT compared to post-menopausal women not prescribed HRT (OR = 1.23, 95% CI [1.01–1.51] p-value = 0.0395). These associations persisted in sensitivity analysis over 5 years (OR = 1.65, 95% CI [1.13–2.41] p-value = 0.0086). HRT was associated with increased GI symptoms, including early satiety (OR = 1.22, 95% CI [1.03–1.45] p-value = 0.0187), domperidone use (OR = 2.40, 95% CI [1.14–5.02] p-value = 0.0163), and undergoing gastric emptying studies (OR = 1.67, 95% CI [1.39–2.01] p-value < 0.0001). HRT is linked to an increased risk of developing an ICD encounter diagnosis of gastroparesis. Full article
(This article belongs to the Special Issue Personalized Medicine of Digestive Diseases)
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