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Skin Pathophysiology and Management
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Skin Pathophysiology and Management

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2916

Special Issue Editors

Dr. Mohamad Goldust

E-Mail Website
Guest Editor
Department of Dermatology, Yale School of Medicine, Yale University, New Haven, CT 06510, USA
Interests: dermatology; genodermatoses; skin technology; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Dr. Joanna Goldberg

E-Mail Website
Guest Editor Assistant
Department of Dermatology, George Washington University School of Medicine, Washington, DC 20037, USA
Interests: skin cancer; melanoma; dermoscopy; artificial intelligence; systematic review
Dr. Mahsa Babaei

E-Mail Website
Guest Editor Assistant
School of Medicine, Stanford University, Stanford, CA 94305, USA
Interests: genetic skin disorders; artificial intelligence; inflammatory skin diseases

Special Issue Information

Dear Colleagues,

Skin is one of the most complex organs in the body. Although many advances in the diagnosis and treatment of cutaneous diseases have been made in recent years, much remains to be elucidated due to the structural complexity of the skin and its connection with other body organs. With the recent advances in the use of technology in medicine, the use of genetics in the diagnosis and treatment of diseases, and new biological drugs, great strides have been made in the recognition and management of cutaneous disorders, although much remains to be discovered. In this context, the editors of the Journal of Personalized Medicine have set up a Special Issue dedicated to skin pathophysiology and management. For this Special Issue, we invite research articles on various aspects of skin pathophysiology and management.

Dr. Mohamad Goldust
Guest Editor

Dr. Joanna Goldberg
Dr. Mahsa Babaei
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Personalized Medicine is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • skin disease pathophysiology
  • skin disease diagnosis
  • skin disease treatment

Published Papers (2 papers)

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Research

13 pages, 1056 KiB  
Article
A Panel of Potential Serum Markers Related to Angiogenesis, Antioxidant Defense and Hypoxia for Differentiating Cutaneous Squamous Cell Carcinomas from Actinic Keratoses
by Simona Roxana Georgescu, Sandra Milena Tocut, Clara Matei, Corina Daniela Ene, Ilinca Nicolae and Mircea Tampa
J. Pers. Med. 2024, 14(1), 103; https://doi.org/10.3390/jpm14010103 - 17 Jan 2024
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Abstract
Cutaneous squamous cell carcinoma (cSCC) arising from the malignant proliferation of epidermal keratinocytes is the second most common skin cancer. Actinic keratosis (AK), which is considered cSCC in situ, may progress into invasive tumors. Currently, there are no serum markers that can differentiate [...] Read more.
Cutaneous squamous cell carcinoma (cSCC) arising from the malignant proliferation of epidermal keratinocytes is the second most common skin cancer. Actinic keratosis (AK), which is considered cSCC in situ, may progress into invasive tumors. Currently, there are no serum markers that can differentiate cSCC from AK. The aim of our study was to assess angiogenesis and oxidative stress in patients with cSCC and patients with AK and find reliable serum markers useful in the diagnosis of cSCC. We have determined the serum levels of a group of proangiogenic factors (MMP-2, MMP-9, VEGF, FGF2), the total antioxidative status/capacity (TAS/TAC), ImAnOx, a marker of oxidative stress, and HIF-1 alpha, an indicator of hypoxia. We have identified higher serum levels of MMP-2. MMP-9, VEGF, FGF2 and HIF-1 alpha and lower levels of ImAnOx in cSCC patients compared to AK patients and controls. There were no statistically significant differences between AK patients and controls. We have found positive correlations between proangiogenic markers and HIF-1 alpha and negative correlations between proangiogenic markers and ImAnOx. Our results suggest that MMP-2, MMP-9, VEGF, FGF2, ImAnOx and HIF-1 may be promising markers for differentiating AK from cSCC, and there is a link between angiogenesis, oxidative stress and hypoxia. Full article
(This article belongs to the Special Issue Skin Pathophysiology and Management)
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23 pages, 3106 KiB  
Article
Influence of Moisturizers on Skin Microcirculation: An Assessment Study Using Laser Speckle Contrast Imaging
by Ignace De Decker, Tanja Klotz, Peter Vu, Henk Hoeksema, Kimberly De Mey, Anse Beeckman, Bob Vermeulen, Marijn Speeckaert, Phillip Blondeel, Marcus Wagstaff, Stan Monstrey and Karel E. Y. Claes
J. Pers. Med. 2023, 13(10), 1507; https://doi.org/10.3390/jpm13101507 - 18 Oct 2023
Viewed by 1689
Abstract
Non-invasive scar management typically involves pressure therapy, hydration with silicones or moisturizers, and UV protection. Moisture loss from scars can lead to hypertrophic scar formation. Pressure therapy reduces blood flow, fibroblast activity, and transforming growth factor beta 1 (TGF-β1) release. This study examined [...] Read more.
Non-invasive scar management typically involves pressure therapy, hydration with silicones or moisturizers, and UV protection. Moisture loss from scars can lead to hypertrophic scar formation. Pressure therapy reduces blood flow, fibroblast activity, and transforming growth factor beta 1 (TGF-β1) release. This study examined various moisturizers and liquid silicone gel’s impact on microcirculation. 40 volunteers participated in a study where superficial abrasions were created to induce trans epidermal water loss (TEWL). Five moisturizers (TEDRA®, TEDRA® NT1, TEDRA® NT3, Alhydran®, Lipikar®) and BAP Scar Care® silicone gel were tested. TEWL, hydration, and blood flow were measured up to 4 h post-application. Results showed that silicone had the least impact on occlusion and hydration. Alhydran® reduced blood flow the most, while Lipikar® increased it the most. TEDRA® NT1 had reduced flow compared to TEDRA® and TEDRA® NT3. All TEDRA® products exhibited high hydration, and all but silicone showed good occlusion. Moisturizers influenced skin microcirculation, with some causing decrease, while others increased flow. However, the clinical impact on scarring remains unclear compared to the evident effects of hydration and occlusion. More research is necessary to study moisturizers alone and with pressure therapy on scars, along with potential adverse effects of increased microcirculation on scars. Full article
(This article belongs to the Special Issue Skin Pathophysiology and Management)
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