Pathophysiology of Retinopathy in Precision Medicine Era

A special issue of Journal of Personalized Medicine (ISSN 2075-4426). This special issue belongs to the section "Clinical Medicine, Cell, and Organism Physiology".

Deadline for manuscript submissions: 11 December 2024 | Viewed by 941

Special Issue Editors


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Guest Editor
AIBILI—Association for Innovation and Biomedical Research on Light and Image, 3000-548 Coimbra, Portugal
Interests: diabetic retinopathy; macular degeneration

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Guest Editor
Department of Ophthalmology, Tufts University School of Medicine, Boston, MA, USA
Interests: age-related macular degeneration; OCT imaging

Special Issue Information

Dear Colleagues,

Sight in humans is the primary sense for the perception of the surrounding environment and social relationships. Central to the process of vision is the retina, a light-sensing tissue that lines the back of the eye, which converts light signals into electric signals that the brain finally interprets as vision. Retinal diseases, the leading causes of vision loss and blindness, are associated with complicated pathogeneses such as angiogenesis, inflammation, immune regulation, fibrous proliferation, and neurodegeneration.

This Special Issue aims to broaden the knowledge of the physiology together with diagnostic and therapeutic methods that may be used in the treatment of retinopathy. Original articles and reviews highlighting progresses regarding its novel treatment and mechanisms will be welcome.

Dr. Luís Guilherme Arneiro Mendes
Dr. Daniela Ferrara
Guest Editors

Manuscript Submission Information

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Keywords

  • diabetic retinopathy
  • macular degeneration
  • age-related macular degeneration
  • OCT imaging
  • ophthalmology

Published Papers (1 paper)

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Research

12 pages, 1703 KiB  
Article
Mechanical Ventilation, Retinal Avascularity and Rate of Vascularisation: A Triad of Predictors for Retinopathy of Prematurity Treatment
by Olena Protsyk and José Luis García Serrano
J. Pers. Med. 2024, 14(4), 379; https://doi.org/10.3390/jpm14040379 - 31 Mar 2024
Viewed by 697
Abstract
Aim: The temporal avascular area of the retina and the duration of mechanical ventilation (DMV) may predict the need to treat retinopathy of prematurity (ROP). This study considers whether the rate of retinal vascularisation and related risk factors should be included in a [...] Read more.
Aim: The temporal avascular area of the retina and the duration of mechanical ventilation (DMV) may predict the need to treat retinopathy of prematurity (ROP). This study considers whether the rate of retinal vascularisation and related risk factors should be included in a predictive model of the need for ROP treatment. Methods: This single-centre, observational retrospective case–control study was conducted on 276 preterm infants included in an ROP screening programme. All had undergone at least three examinations of the fundus. The main outcome measures considered were DMV (in days of treatment), the temporal avascular area (in disc diameters, DD) and the rate of temporal retinal vascularisation (DD/week). Results: The multivariate logistic model that best explains ROP treatment (R2 = 63.1%) has three significant risk factors: each additional day of mechanical ventilation (OR, 1.05 [95% CI, 1.02–1.09]; p = 0.001); each additional DD of temporal avascular area (OR, 2.2 [95% CI, 1.7–2.9]; p < 0.001) and a vascularisation rate <0.5 DD/week (OR, 19.0 [95% CI, 6.5–55.5]; p < 0.001). Two tables are presented for calculating the expected need for ROP treatment according to these three risk factors. Conclusions: A greater DMV, a broad avascular area of the temporal retina at the first binocular screening and slow retinal vascularisation strongly predict the need for ROP treatment. The predictive model we describe must be validated externally in other centres. Full article
(This article belongs to the Special Issue Pathophysiology of Retinopathy in Precision Medicine Era)
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