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The Role of Endocrine-Disrupting Chemicals in the Human Health
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The Role of Endocrine-Disrupting Chemicals in the Human Health

A special issue of Journal of Xenobiotics (ISSN 2039-4713). This special issue belongs to the section "Emerging Chemicals".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 5787

Special Issue Editor

Dr. Elisa Cairrao

E-Mail Website
Guest Editor
1. CICS-UBI, Health Sciences Research Centre, University of Beira Interior, 6200-506 Covilhã, Portugal
2 FCS—UBI, Faculty of Health Sciences, University of Beira Interior, 6200-506 Covilhã, Portugal
Interests: endocrine disruptors; human exposome; pregnancy exposome; phthalates; flame retardants; UVB-filters; bisphenols; cardiovascular endocrinology; fetoplacental vasculature; vascular smooth muscle cells; neurovascular unit; hypertensive disorders in pregnancy; hypothyroidism; calcium and potassium channels; sex hormones; patch clamp
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Human exposure to various environmental contaminants called endocrine-disrupting chemicals (EDCs) is continuous and can lead to adverse effects on human health. Exposure to these EDCs is a global concern due to their adverse effects on the human endocrine system. Moreover, the cellular and molecular mechanisms by which EDCs interact with hormonal action are complex and difficult to understand. For this reason, knowledge of these mechanisms is one of the current challenges of endocrine research.

This Special Issue will focus on the advances of emerging contaminants’ role on human health. The aim is to provide an integrative, novel, and transdisciplinary approach to evaluate actual human exposure to EDC and contribute to the prevention and treatment of diseases. The theme is multidisciplinary, so I invite you to submit original research and review articles on the following non-exhaustive list of topics:

  • Environmental health;
  • Risk assessment;
  • Health impact assessment;
  • Endocrine-disrupting chemicals;
  • Cellular and molecular mechanistic;
  • In vitro studies;
  • Translational research;
  • Molecular docking.

Dr. Elisa Cairrao
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Xenobiotics is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endocrine disruption
  • risk assessment
  • human exposome
  • emerging compounds
  • adverse outcomes pathways
  • animal translational studies

Published Papers (2 papers)

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Research

19 pages, 3399 KiB  
Article
Exposure to DEP Modifies the Human Umbilical Artery Vascular Resistance Contributing to Hypertension in Pregnancy
by Melissa Mariana, Amadeu M. V. M. Soares, Miguel Castelo-Branco and Elisa Cairrao
J. Xenobiot. 2024, 14(2), 497-515; https://doi.org/10.3390/jox14020030 - 18 Apr 2024
Viewed by 316
Abstract
Hypertensive disorders in pregnancy (HDP) are the most prevalent diseases during pregnancy. In addition to the already identified risk factors, exposure to environmental contaminants has been also considered a new one. Phthalates, which are classified as priority environmental pollutants due to their ubiquitousness [...] Read more.
Hypertensive disorders in pregnancy (HDP) are the most prevalent diseases during pregnancy. In addition to the already identified risk factors, exposure to environmental contaminants has been also considered a new one. Phthalates, which are classified as priority environmental pollutants due to their ubiquitousness and endocrine disrupting properties, have been implicated in HDP in some epidemiological studies. Nevertheless, phthalates’ vascular impacts still need to be clarified. Thus, we aimed to understand the connection between phthalates exposure and the occurrence of gestational hypertension, as well as the pathway involved in the pathological vascular effects. We investigated diethyl phthalate’s (DEP) effect on the vascular reactivity of the human umbilical arteries (HUAs) from normotensive and hypertensive pregnant women. Both DEP’s nongenomic (within minutes effect) and genomic (24 h exposure to DEP) actions were evaluated, as well as the contribution of cyclic guanosine monophosphate and Ca2+ channel pathways. The results show that short-term exposure to DEP interferes with serotonin and histamine receptors, while after prolonged exposure, DEP seems to share the same vasorelaxant mechanism as estrogens, through the NO/sGC/cGMP/PKG signaling pathway, and to interfere with the L-type Ca2+ channels. Thus, the vascular effect induced by DEP is similar to that observed in HUA from hypertensive pregnancies, demonstrating that the development of HDP may be a consequence of DEP exposure. Full article
(This article belongs to the Special Issue The Role of Endocrine-Disrupting Chemicals in the Human Health)
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10 pages, 1056 KiB  
Article
Early Female Transgender Identity after Prenatal Exposure to Diethylstilbestrol: Report from a French National Diethylstilbestrol (DES) Cohort
by Laura Gaspari, Marie-Odile Soyer-Gobillard, Scott Kerlin, Françoise Paris and Charles Sultan
J. Xenobiot. 2024, 14(1), 166-175; https://doi.org/10.3390/jox14010010 - 12 Jan 2024
Cited by 1 | Viewed by 4912
Abstract
Diagnostic of transsexualism and gender incongruence are terms to describe individuals whose self-identity does not match their sex assignment at birth. A transgender woman is an individual assigned male at birth (AMAB) on the basis of the external or internal genitalia who identifies [...] Read more.
Diagnostic of transsexualism and gender incongruence are terms to describe individuals whose self-identity does not match their sex assignment at birth. A transgender woman is an individual assigned male at birth (AMAB) on the basis of the external or internal genitalia who identifies and lives as a woman. In recent decades, a significant increase in the number of transgender people has been reported. Although, its etiology is unknown, biological, anatomical, genetic, environmental and cultural factors have been suggested to contribute to gender variation. In XY animals, it has been shown that environmental endocrine disruptors, through their anti-androgenic activity, induce a female identity. In this work, we described four XY individuals who were exposed in utero to the xenoestrogen diethylstilbesterol (DES) and were part of the French HHORAGES cohort. They all reported a female transgender identity starting from childhood and adolescence. This high prevalence of male to female transgenderism (1.58%) in our cohort of 253 DES sons suggests that exposure to chemicals with xenoestrogen activity during fetal life may affect the male sex identity and behavior. Full article
(This article belongs to the Special Issue The Role of Endocrine-Disrupting Chemicals in the Human Health)
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