Special Issue "Liquid Biopsy in Solid Tumors"

A special issue of Journal of Molecular Pathology (ISSN 2673-5261).

Deadline for manuscript submissions: closed (1 September 2023) | Viewed by 3562

Special Issue Editors

Special Issue Information

Dear Colleagues,

Liquid biopsies represent one of the most exciting revolutions of the predictive molecular pathology era. The term 'liquid biopsy' refers to test that are carried out on a number of different biological fluids, including but not limited to plasma, cefalorachidian liquid, effusions and urine. The application of next generation technology to liquid biopsies has allowed for a quantum leap in the detection and monitoring of different genetic alterations, and it has become one of the key weapons able to improve the clinical outcome of different cancer patients.

In this Special Issue, we would like to discuss new insights into the liquid biopsy landscape that may be useful to improve the diagnosis, prognosis and treatment of solid tumours, with a special focus on the application of next-generation technologies to different types of liquid biopsy-derived analytes.

Dr. Umberto Malapelle
Dr. Francesco Passiglia
Guest Editors

Manuscript Submission Information

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Keywords

  • liquid biopsy
  • solid tumors
  • next-generation technologies
  • target treatment

Published Papers (3 papers)

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Research

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Article
Langerhans Cell Histiocytosis-Associated Pulmonary Adenocarcinoma: A Word of Caution during Molecular Determinations
J. Mol. Pathol. 2022, 3(4), 286-292; https://doi.org/10.3390/jmp3040024 - 03 Nov 2022
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Abstract
Background: Smoking habit is a common cause of pulmonary Langerhans cell histiocytosis (PLCH) and lung cancer and both diseases may coexist in the lung and share genetic alterations, such as V600E BRAF mutations. We collected a small series of three cases of PLCH-associated [...] Read more.
Background: Smoking habit is a common cause of pulmonary Langerhans cell histiocytosis (PLCH) and lung cancer and both diseases may coexist in the lung and share genetic alterations, such as V600E BRAF mutations. We collected a small series of three cases of PLCH-associated lung adenocarcinoma in order to evaluate the molecular setup in both components and underline the critical role of careful tissue selection for predictive molecular driver testing. Methods: Three cases of PLCH-associated adenocarcinoma were collected from consultation files. Clinical data from referring physicians and clinical data were obtained. The surgical biopsies were tested by immunohistochemistry and molecular analysis after separate dissection of adenocarcinoma cells and Langerhans histiocytes. Results: There were three active smoking men with a median age at diagnosis of 60.6 years. PLCH was disclosed at imaging during work-up for suspected lung cancer. Molecular analysis revealed KRAS (G12C and G13C) mutations in two cases and V600E BRAF mutation in one case of PLCH. Immunostaining with the V600E BRAF mutation specific primary antibody VE1 correctly recognized BRAF-mutated LCH. One case was wild-type in both diseases. Two similar cases were found in the literature, one of which showed a discrepant KRAS (G12D) mutation in adenocarcinoma and a V600E BRAF mutation in LCH; Conclusions: This case series of PLCH-associated adenocarcinoma underline the possibility to disclose identical genetic alterations in co-existing benign and malignant pathologies, then potentially creating erroneous interpretation of molecular analysis leading to inadequate therapeutic options in case of incorrect diagnostic recognition and inappropriate selection of both components through microdissection. Full article
(This article belongs to the Special Issue Liquid Biopsy in Solid Tumors)
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Review

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Review
Liquid Biopsy in Advanced Colorectal Cancer: Clinical Applications of Different Analytes
J. Mol. Pathol. 2023, 4(3), 128-155; https://doi.org/10.3390/jmp4030013 - 05 Jul 2023
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Abstract
Colorectal cancer is one of the most prevalent cancers nowadays. In the metastatic setting, diagnosis and treatment have relied on tumor tissue analysis. However, the different limitations of this approach have recently opened the door to the introduction of liquid biopsy in the [...] Read more.
Colorectal cancer is one of the most prevalent cancers nowadays. In the metastatic setting, diagnosis and treatment have relied on tumor tissue analysis. However, the different limitations of this approach have recently opened the door to the introduction of liquid biopsy in the clinical setting. Liquid biopsy provides real-time information about the tumor and its heterogeneity in a simple, non-invasive, and repeatable way. There are several analytes that can be sought: exosomes, circulating tumor cells, and circulating tumor DNA, showing promising results in the areas of early detection, minimal residual disease, prognosis, or response to treatment. Here, we review the clinical applications of liquid biopsy in advanced colorectal cancer patients, focusing on metastatic diagnosis, prognostic assessment, drug sensitivity, treatment response, and acquired resistance monitoring. Full article
(This article belongs to the Special Issue Liquid Biopsy in Solid Tumors)
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Opinion
Liquid Biopsy in EGFR-Mutated Advanced NSCLC from T790M to MET Amplification: Clinical Implications and Possibilities in the Resistance Setting
J. Mol. Pathol. 2023, 4(2), 81-88; https://doi.org/10.3390/jmp4020009 - 30 Apr 2023
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Abstract
According to the ESMO and ASCO clinical guidelines, the main role of liquid biopsy in EGFR+ advanced NSCLC patients is represented by T790M detection after erlotinib/gefitinib/afatinib progression. However, the general international expert consensus regards osimertinib as the preferred upfront treatment in this [...] Read more.
According to the ESMO and ASCO clinical guidelines, the main role of liquid biopsy in EGFR+ advanced NSCLC patients is represented by T790M detection after erlotinib/gefitinib/afatinib progression. However, the general international expert consensus regards osimertinib as the preferred upfront treatment in this setting; therefore, this role has been scaled back in recent years. As of today, liquid biopsy has no ASCO or ESMO recommendation following first-line osimertinib; in the same vein, no targeted therapy has received ASCO or ESMO recommendation following post upfront Osimertinib progression. However, this standard could change in the near future. Therefore, adopting a clinical point of view, this paper aims to provide a comprehensive review on the previous, the current and the possible future role of liquid biopsy in the framework of the diagnostic–therapeutic algorithm of EGFR+ advanced NSCLC. Full article
(This article belongs to the Special Issue Liquid Biopsy in Solid Tumors)
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