Novel Nanoparticles for Biomedical Application

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 2915

Special Issue Editors


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Guest Editor
Biomaterials, Fraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Wuerzburg, Germany
Interests: development of multifunctional (nano)particles for diagnostics and regenerative medicine; bioresorbable fibers; synthesis automation

E-Mail Website
Guest Editor
Biomaterials, Fraunhofer Institute for Silicate Research ISC, Translational Center Regenerative Therapies TLC-RT, Wuerzburg, Germany
Interests: bioresorbable pressure spun and electronspun fibers for biomedical applications; particle-based drug delivery systems; bioresorbable coatings for medical implants and pharmaceutical tablets

Special Issue Information

Dear Colleagues,

It is hard to imagine biomedical research today without a decisive role for nanoparticles. Due to their unique properties and size, which are similar to those of biomolecules, the application potential of nanoparticles is huge in this field. Firstly, there are plenty of different novel synthesis procedures to prepare nanoparticles of various property profiles (composition, size, structures, surface modification, etc.). Secondly, since analytical methods are becoming more and more sophisticated, we are learning how an intelligent combination of nanoparticle properties can interact with a physiological environment in a positive manner. This results in improvements in diagnostics as well as in therapy.

Biomedical nanoparticles can be prepared for in vitro or in vivo imaging, bind biomarkers, be functionalized for proper targeting, encapsulate, transport, and release drugs, and finally improve the properties of existing medical and pharmaceutical products and thus extend the range of their application.

It is our pleasure to invite you to submit full research papers, review articles, opinions, and communications to this Special Issue focusing on “Novel Nanoparticles for Biomedical Application”, including but not limited to novel multifunctional nanoparticles for diagnostic and therapeutic approaches, syntheses, and surface modification strategies to overcome different biological barriers, and also topics related to biosensing.

Dr. Sofia Dembski
Dr. Jörn Probst
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biomedical nanoparticles
  • diagnostics
  • theranostics
  • nanopharmaceuticals
  • nanodevices

Published Papers (1 paper)

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Research

19 pages, 5087 KiB  
Article
Synthesis and Characterization of Ceramide-Containing Liposomes as Membrane Models for Different T Cell Subpopulations
by Sascha Eder, Claudia Hollmann, Putri Mandasari, Pia Wittmann, Fabian Schumacher, Burkhard Kleuser, Julian Fink, Jürgen Seibel, Jürgen Schneider-Schaulies, Christian Stigloher, Niklas Beyersdorf and Sofia Dembski
J. Funct. Biomater. 2022, 13(3), 111; https://doi.org/10.3390/jfb13030111 - 2 Aug 2022
Cited by 1 | Viewed by 2199
Abstract
A fine balance of regulatory (Treg) and conventional CD4+ T cells (Tconv) is required to prevent harmful immune responses, while at the same time ensuring the development of protective immunity against pathogens. As for many cellular processes, sphingolipid [...] Read more.
A fine balance of regulatory (Treg) and conventional CD4+ T cells (Tconv) is required to prevent harmful immune responses, while at the same time ensuring the development of protective immunity against pathogens. As for many cellular processes, sphingolipid metabolism also crucially modulates the Treg/Tconv balance. However, our understanding of how sphingolipid metabolism is involved in T cell biology is still evolving and a better characterization of the tools at hand is required to advance the field. Therefore, we established a reductionist liposomal membrane model system to imitate the plasma membrane of mouse Treg and Tconv with regards to their ceramide content. We found that the capacity of membranes to incorporate externally added azide-functionalized ceramide positively correlated with the ceramide content of the liposomes. Moreover, we studied the impact of the different liposomal preparations on primary mouse splenocytes in vitro. The addition of liposomes to resting, but not activated, splenocytes maintained viability with liposomes containing high amounts of C16-ceramide being most efficient. Our data thus suggest that differences in ceramide post-incorporation into Treg and Tconv reflect differences in the ceramide content of cellular membranes. Full article
(This article belongs to the Special Issue Novel Nanoparticles for Biomedical Application)
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