Bone Tissue Engineering: Recent Advances and Translation to Clinical Application
A special issue of Journal of Functional Biomaterials (ISSN 2079-4983). This special issue belongs to the section "Bone Biomaterials".
Deadline for manuscript submissions: 31 August 2024 | Viewed by 1184
Special Issue Editors
Interests: 3D printing; biomaterials; scaffolds; bone tissue engineering; maxillofacial regeneration; preclinical research; regenerative medicine
Special Issue Information
Dear Colleagues,
The treatment and regeneration of large bone defects in the skeleton are complex, pose significant clinical challenges to surgeons and scientists, and impose a tremendous burden on healthcare systems worldwide. Even though bone tissue possesses the unique and intrinsic ability to heal, large bone defects have a limited capacity for spontaneous repair and often experience a poor long-term recovery. Despite innovations in surgical techniques, current clinical strategies for bone defect regeneration demonstrate significant limitations and drawbacks, including donor-site morbidity, the risk of infection, poor anatomical match, insufficient bone volume, higher costs, bone graft resorption, and rejection. In recent decades, advances in computer-assisted planning, three-dimensional (3D) printing technology, and bone tissue engineering (BTE) have offered promising novel treatment alternatives by employing biocompatible scaffold materials, autologous mesenchymal stem cells, and growth factors. Furthermore, the complex signaling cascade of the native immune system plays a crucial role in determining the efficacy and viability of the tissue-engineered implant. It forms an essential component of the BTE strategy. These approaches have provided a new platform for basic and translational research, and have exhibited promising results with regard to large bone regeneration that might profoundly improve patients’ function, form, and quality of life. Thus, 3D printing and BTE strategies are exciting, sustainable, personalized, and minimally invasive alternatives to bone harvesting techniques, and are therefore poised to significantly impact clinical outcomes.
This Special Issue aims to compile the recent advances in bone tissue engineering and their scientific and clinical applications. We welcome original research articles and comprehensive reviews that address the following topics: preclinical research; clinical trials; advances in biomaterials for bone tissue engineering; 3D printing and bioprinting technologies; and scaffold–immune system interactions.
Dr. Fernando Guastaldi
Dr. Bhushan Mahadik
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- bone tissue engineering
- regenerative medicine
- biomaterials
- scaffolds
- 3D printing
- mesenchymal stem cells
- growth factors
- immunological response
- translational research
- clinical trials
