Review Special Issue Series: Neoadjuvant Lung Cancer Surgery

A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Pulmonology".

Deadline for manuscript submissions: 12 June 2024 | Viewed by 821

Special Issue Editors


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Guest Editor
Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy
Interests: lung cancer; lung cancer surgery; biostatistics
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
1. Department of Thoracic Surgery, IEO, European Institute of Oncology IRCCS, Milan, Italy
2. Department of Oncology and Hemato-Oncology, University of Milan, Milan, Italy
Interests: thoracic oncology; lung cancer; thoracic surgery

Special Issue Information

Dear Colleagues,

Neoadjuvant lung cancer surgery is a comprehensive and innovative approach to treating lung cancer, which has gained significant attention and recognition in oncology. This approach represents a departure from traditional methods of lung cancer management, as it involves the administration of treatments before surgery rather than after it. In neoadjuvant lung cancer surgery, patients typically receive chemotherapy, radiation therapy, targeted therapy, or immunotherapy before surgical tumor removal. The primary goal of this preoperative treatment is to shrink the tumor, control its growth, or eliminate any cancer cells that may have spread beyond the lung. By reducing the tumor's size or rendering it more manageable, neoadjuvant therapy can make surgical resection safer and more effective. This multidisciplinary approach is crucial for patients with locally advanced lung cancer or tumors that are surgically difficult to remove due to their size or location. Neoadjuvant therapy increases the chances of successful surgical outcomes and allows healthcare providers to tailor treatment plans to individual patient needs, offering a higher potential for long-term cancer control. As advancements in cancer research and treatment modalities continue to evolve, neoadjuvant lung cancer surgery stands as a crucial strategy in the fight against this devastating disease, offering patients the prospect of improved outcomes and a better quality of life. 

We hope this new issue will be of interest to you, and we look forward to receiving your comprehensive review papers.

Dr. Luca Bertolaccini
Prof. Dr. Lorenzo Spaggiari
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neoadjuvant therapy
  • lung cancer surgery
  • multidisciplinary approach
  • personalized treatment
  • cancer research advances

Published Papers (1 paper)

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Review

13 pages, 507 KiB  
Review
Revolutionizing Localized Lung Cancer Treatment: Neoadjuvant Chemotherapy plus Immunotherapy for All?
by Victoria Ferrari and Carole Helissey
J. Clin. Med. 2024, 13(9), 2715; https://doi.org/10.3390/jcm13092715 - 5 May 2024
Viewed by 659
Abstract
Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across [...] Read more.
Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across early stages. While perioperative chemotherapy offers some benefit, outcomes vary. Therefore, novel therapeutic approaches are imperative to improve patient survival. The combination of chemotherapy and immunotherapy emerges as a promising avenue. In this review, we explore studies demonstrating the benefits of this combination therapy, its impact on surgical procedures, and patient quality of life. However, challenges persist, particularly for patients failing to achieve pathologic complete response (pCR), those with stage II lung cancer, and individuals with specific genetic mutations. Additionally, identifying predictive biomarkers remains challenging. Nevertheless, the integration of immunotherapy and chemotherapy in the preoperative setting presents a new paradigm in managing resectable lung cancer, heralding more effective and personalized treatments for patients. Full article
(This article belongs to the Special Issue Review Special Issue Series: Neoadjuvant Lung Cancer Surgery)
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Title: Revolutionizing localized lung cancer treatment: Neoadjuvant chemotherapy plus immunotherapy for all?
Authors: Victoria FERRARI; Carole HELISSEY
Affiliation: Military Hospital Begin
Abstract: Lung cancer poses a significant public health challenge, with resectable non-small cell lung cancer (NSCLC) representing 20 to 25% of all NSCLC cases, staged between I and IIIA. Despite surgical interventions, patient survival remains unsatisfactory, with approximately 50% mortality within 5 years across early stages. While perioperative chemotherapy offers some benefit, outcomes vary. Therefore, novel therapeutic approaches are imperative to improve patient survival. The combination of chemotherapy and immunotherapy emerges as a promising avenue. In this review, we explore studies demonstrating the benefits of this combination therapy, its impact on surgical procedures, and patient quality of life. However, challenges persist, particularly for patients failing to achieve pathologic complete response (pCR), those with stage II lung cancer, and individuals with specific genetic mutations. Additionally, identifying predictive biomarkers remains challenging. Nevertheless, the integration of immunotherapy and chemotherapy in the preoperative setting presents a new paradigm in managing resectable lung cancer, heralding more effective and personalized treatments for patients.

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