Special Issue "Histone Deacetylase Inhibitor in Cancer Therapy"

A special issue of Journal of Clinical Medicine (ISSN 2077-0383).

Deadline for manuscript submissions: closed (10 March 2018)

Special Issue Editor

Department of Visceral Thoracic and Vascular Surgery, Philipps University Marburg, Baldingerstrasse, 35043 Marburg, Germany
Interests: cell death; autophagy; solid cancer; neuro-endocrine; epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epigenetic alterations are able to determine a substantial change in the assets of gene expression patterns.

Modifications of methylation status occur in the genome, leading to silencing or over-expression of genes.

Histone acetylation substantially modifies the structure of the histone core, providing the DNA sequence the possibility of being accessible by the transcription factor at the promoter region of genes, leading to the transcription of the corresponding genome code.

Hypo-acetylation has been implicated in malignant transformations and tumor progression, thus characterizing the epi-genome profile of cancer cells.

Since the discovery of the antifungal antibiotic Trichostatin A and its ability to inhibit the histone deacetylase, several other HDACi (histone deacetylase inhibitors) have been newly synthetized.

Current research has shown that the inhibition of histone deacetylase is capable of restoring the expression of genes implicated in cell cycle blockade and cell death, thus improving classical chemotherapy by overcoming multiple drug resistance.

Histone deacetylase inhibitors have a high potential in cancer therapy and their mechanisms of action are not yet fully elucidated.

Dr. Pietro Di Fazio
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Solid tumors
  • Clinical advances
  • Cell death
  • Apoptosis
  • Endoplasmic reticulum stress
  • Autophagy
  • In vivo/in vitro tumor models

Published Papers

There is no accepted submissions to this special issue at this moment.
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