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A special issue of Journal of Clinical Medicine (ISSN 2077-0383). This special issue belongs to the section "Dermatology".

Deadline for manuscript submissions: closed (20 September 2023) | Viewed by 10667

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Special Issue Editor

Dr. Neelam Vashi

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Guest Editor

Department of Dermatology, Boston University School of Medicine, Boston, MA 02215, USA
Interests: ethnic skin; cosmetic dermatology

Special Issue Information

Dear Colleagues,

Cosmetic surgery and skin care have become a billion-dollar industry due to the population’s rising demand to maintain a youthful, aesthetically appealing appearance. Cosmetic dermatology is becoming increasingly popular, cross-culturally and across all ages and skin types. Due to the ever-growing number of submissions in this field, the editors of Journal of Clinical Medicine have set up a Special Issue dedicated to this field within dermatology. For this Special Issue, we invite research articles on various aspects of cosmetic and aesthetic dermatology.

Dr. Neelam Vashi
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Clinical Medicine is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

healthy skin
skin maintenance
ageing skin
endocrinology and neuroimmunology of healthy skin
imaging
skin measurement
quality of life
skin types
sensitive skin
rosacea and acne
sebum
sweat
fat
phlebology
aesthetic dermatology
cosmetic dermatology
aesthetic surgery

Published Papers (5 papers)

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Research

10 pages, 1248 KiB

Open AccessArticle

Efficacy, Safety, and Subject Satisfaction of PrabotulinumtoxinA for Moderate-to-Severe Crow’s Feet: A Phase IV, Multicenter, Double-Blind, Randomized, Placebo-Controlled Trial

by Soo-Kyung Lee, Myoung Shin Kim, Soon-Hyo Kwon, Bo Young Chung, Se Hee Han and Hyoung Jun Kim

J. Clin. Med. 2023, 12(19), 6326; https://doi.org/10.3390/jcm12196326 - 1 Oct 2023

Viewed by 880

Abstract

PrabotulinumtoxinA has been identified as an effective agent against crow’s feet. Our study, which included Korean patients with moderate to severe crow’s feet, was undertaken to compare the efficacy and safety of PrabotulinumtoxinA and placebo treatments. Of the 90 study participants, 60 received prabotulinumtoxinA (24 U), whereas 30 received a placebo. The primary outcome assessment included facial wrinkle grading by investigators. At week 4, 69.64% of patients in the prabotulinumtoxinA group exhibited minimal crow’s feet severity; in contrast, a 0% improvement was observed in the placebo group (p < 0.0001). At week 12, the improvement rates were 30.36% for prabotulinumtoxinA and 6.90% for the placebo, demonstrating a significant difference (p = 0.0152). Based on the independent review panel’s assessment at week 4, the improvement rate was 39.29% in the prabotulinumtoxinA group and 3.45% in the placebo group during maximum smiling. Additionally, patient satisfaction was notably higher in the prabotulinumtoxinA group (32.14%) than in the placebo group (10.34%) at week 4 (p = 0.0289). Both treatments displayed comparable safety profiles, with only mild local reactions reported as ADRs for one patient from the prabotulinumtoxinA group. Thus, prabotulinumtoxinA demonstrates significant potential as a potent and safe remedy for crow’s feet. Full article

(This article belongs to the Special Issue Cosmetic Dermatology in the Digital Age)

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12 pages, 1303 KiB

Open AccessArticle

Quantitative Assessment of Hyperpigmentation Changes in Human Skin after Microneedle Mesotherapy Using the Gray-Level Co-Occurrence Matrix (GLCM) Method

by Iga Wawrzyk-Bochenek, Mansur Rahnama, Sławomir Wilczyński and Anna Wawrzyk

J. Clin. Med. 2023, 12(16), 5249; https://doi.org/10.3390/jcm12165249 - 11 Aug 2023

Cited by 2 | Viewed by 1161

Abstract

Aim: The aim of the study was to quantitatively assess the effectiveness of microneedle mesotherapy in reducing skin discoloration. The results were analyzed using the gray-level co-occurrence matrix (GLCM) method. Material and methods: The skin of the forearm (7 × 7 cm) of 12 women aged 29 to 68 was examined. Microneedle mesotherapy was performed using a dermapen with a preparation containing 12% ascorbic acid. Each of the volunteers underwent a series of four microneedle mesotherapy treatments. The effectiveness of the treatment was quantified using the methods of image analysis and processing. A series of clinical images were taken in cross-polarized light before and after a series of cosmetic procedures. Then, the treated areas were analyzed by determining the parameters of the gray-level co-occurrence matrix (GLCM) algorithm: contrast and homogeneity. Results: During image pre-processing, the volunteers’ clinical images were separated into red (R), green (G) and blue (B) channels. The photos taken after the procedure show an increase in skin brightness compared to the photos taken before the procedure. The average increase in skin brightness after the treatment was 10.6%, the average decrease in GLCM contrast was 10.7%, and the average homogeneity increased by 14.5%. Based on the analysis, the greatest differences in the GLCM contrast were observed during tests performed in the B channel of the RGB scale. With a decrease in GLCM contrast, an increase in postoperative homogeneity of 0.1 was noted, which is 14.5%. Full article

(This article belongs to the Special Issue Cosmetic Dermatology in the Digital Age)

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12 pages, 1222 KiB

Open AccessArticle

Evaluation of the Reduction of Skin Hyperpigmentation Changes under the Influence of a Preparation Containing Kojic Acid Using Hyperspectral Imaging—Preliminary Study

by Iga Wawrzyk-Bochenek, Mansur Rahnama, Martyna Stachura, Sławomir Wilczyński and Anna Wawrzyk

J. Clin. Med. 2023, 12(7), 2710; https://doi.org/10.3390/jcm12072710 - 4 Apr 2023

Cited by 1 | Viewed by 1858

Abstract

Aim: The aim of this study was to demonstrate the effects of using a preparation containing kojic acid on skin hyperpigmentation using hyperspectral imaging, which enables a quantitative assessment of the effect of the preparation used on the reduction of skin discoloration. Materials and methods: Preliminary studies were carried out on 12 patients with post-acne skin. A hyperspectral camera with a spectral range of 400–1000 nm was used to image skin hyperpigmentation before and after the application of 3% kojic acid. Hyperspectral profiles were analyzed, and image analysis and processing methods were applied. Results: Studies performed using a hyperspectral camera have shown that kojic acid reduces skin discoloration by increasing skin brightness in 75% of patients tested, reducing skin contrast in approximately 83% and increasing skin homogeneity in approximately 67% of patients. Full article

(This article belongs to the Special Issue Cosmetic Dermatology in the Digital Age)

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12 pages, 2982 KiB

Open AccessArticle

Efficacy and Safety of the Genistein Nutraceutical Product Containing Vitamin E, Vitamin B3, and Ceramide on Skin Health in Postmenopausal Women: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

by Mingkwan Na Takuathung, Preeyaporn Klinjan, Wannachai Sakuludomkan, Nahathai Dukaew, Ratchanon Inpan, Rattana Kongta, Wantida Chaiyana, Supanimit Teekachunhatean and Nut Koonrungsesomboon

J. Clin. Med. 2023, 12(4), 1326; https://doi.org/10.3390/jcm12041326 - 7 Feb 2023

Cited by 1 | Viewed by 3768

Abstract

Skin aging is one of the most concerning issues that occur after menopause. The Genistein Nutraceutical (GEN) product, containing genistein, vitamin E, vitamin B3, and ceramide, has been formulated as a topical anti-aging product for improving the health of postmenopausal women’s facial skin. This study aimed to investigate the efficacy and safety of the GEN product on postmenopausal women’s facial skin. This randomized, double-blind, placebo-controlled trial randomly assigned 50 postmenopausal women to receive either the GEN product (n = 25) or the placebo (PLA) product (n = 25), topically applied twice daily for 6 weeks. The outcome assessments included multiple skin parameters related to skin wrinkling, color, hydration, and facial skin quality at baseline and week 6. The percentage mean changes or absolute mean changes, where appropriate, in skin parameters were compared between the two groups. The mean age of the participants was 55.8 ± 3.4 years. For skin wrinkling and skin color parameters, only skin redness was significantly higher in the GEN group when compared to the PLA group. Following the application of the GEN product, skin hydration increased while fine pores and their area decreased. Subgroup analysis of older women (age ≥ 56 years) with adequate compliance found significant differences between the two groups in the percentage mean changes of most skin wrinkle parameters. The GEN product has benefits for the facial skin of postmenopausal women, particularly those who are older. It can moisturize facial skin, lessen wrinkles, and enhance redness. Full article

(This article belongs to the Special Issue Cosmetic Dermatology in the Digital Age)

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16 pages, 2972 KiB

Open AccessArticle

The Safety and Efficacy of 1-Monoeicosapentaenoin Isolated from the Trebouxiophyceae Micractinium on Anti-Wrinkle: A Split-Face Randomized, Double-Blind Placebo-Controlled Clinical Study

by Ki Mo Kim, Kon-Young Ji, Yoon Jung Choi, Jong Beom Heo, Ui Joung Youn, Sanghee Kim, Ki-Shuk Shim, Joo Young Lee, Tae Soo Kim, Young Kyoung Seo, Gyu-Yong Song and Sungwook Chae

J. Clin. Med. 2023, 12(2), 587; https://doi.org/10.3390/jcm12020587 - 11 Jan 2023

Cited by 4 | Viewed by 2543

Abstract

The skin aging process is governed by intrinsic and extrinsic factors causing skin wrinkles, sagging, and loosening. The 1-monoeicosapentaenoin (1-MEST) is a component isolated from Micractinium, a genus of microalgae (Chlorophyta, Trebouxiophyceae). However, the anti-wrinkle effects of 1-MEST are not yet known. This study aimed to evaluate the anti-wrinkle effects of 1-MEST in vitro and in clinical trials. The cytotoxicity of 1-MEST was investigated in vitro using the MTS assay in human epidermal keratinocytes (HEKs). Expression of matrix metalloproteinase (MMP)-1 and MMP-9 was determined by ELISA in HEKs irradiated with UVB after treatment with 1-MEST. A split-face randomized, double-blind, placebo-controlled study was conducted to evaluate the safety and efficacy of 1-MEST. The study evaluated wrinkle parameters and visual assessment, self-efficacy and usability questionnaires, and adverse events. The study showed that the 1-MEST was not cytotoxic in HEKs, suppressed MMP-1 secretion and MMP-9 protein expression in HEKs irradiated with UVB. The wrinkle parameters and mean visual assessment score were significantly decreased in the test group after 12 weeks and differed from the control group. There were no significant differences in efficacy and usability. Adverse effects were also not observed. The 1-MEST showed anti-wrinkle properties to slow down or prevent skin aging. Full article

(This article belongs to the Special Issue Cosmetic Dermatology in the Digital Age)

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