Gastric Cancer: Clinical Challenges and New Perspectives

Dear Colleagues,

Surgically determined treatment and care of gastric cancer has experienced great development for more than 15 years.

In particular, the implementation of neoadjuvant chemotherapy has led to substantial progress in surgical therapy and its early postoperative and long-term oncosurgical outcome.

In addition to randomized controlled trials, prospective multicenter observational studies on daily surgical practice for the purpose of quality assurance can be considered a valuable contribution to research and surgical care.

In addition, surgical specimens and tumor tissue have been better characterized step-by-step, e.g., with regard to MSI (in)stability, for a more personalized therapy, focussing increasingly on i) novel antineoplastic substances and their combinations, ii) targeted therapy based on antibodies, and iii) immune-regulating or -modulating drugs and medication, such as check-point inhibitors (depending on the features of the tumor tissue).

From a purely surgical point of view, the surgical potential of recurrent and metastatic tumor growth (i.e., hepatic and peritoneal metastases) as well as prospects for palliative tumor resections have become of great interest in the surgical community. Furthermore, multi-modal treatment concepts as well as gender- and BMI-dependent specifics may be of particular interest with regard to patient-, diagnosis-, tumor tissue- and surgical treatment-associated characteristics (such as perioperative factors and parameters).

Taken together, all the abovementioned aspects are potential topics of interest for this Special Issue of the Journal of Clinical Medicine. We invite the submission of papers focusing on the following topics:

• Evaluating original data;
• Summarizing and discussing available data by means of a meta-analysis, systematic or narrative reviews.

Dr. Claus Wilhelm Schildberg
Prof. Dr. Frank Meyer
Prof. Dr. Aristotelis Perrakis
Guest Editors

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• gastric cancer
• curative/palliative resection
• neoadjuvant chemothrapy
• multimodal treatment
• transthoracically/transhiatally extended gastrectomy
• histopathological investigation
• frozen section
• MSI status
• BMI-specific aspects of gastric cancer surgery
• personalized therapy
• targeted therapy