The Epicardium: Development, Pathology, and Regeneration

A special issue of Journal of Cardiovascular Development and Disease (ISSN 2308-3425). This special issue belongs to the section "Cardiac Development and Regeneration".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 3569

Special Issue Editors


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Guest Editor
Departamento de Biología Experimental, Universidad de Jaen, 23071 Jaen, Spain
Interests: cardiovascular development; transcriptional regulation; noncoding RNAs; atrial fibrillation
Special Issues, Collections and Topics in MDPI journals
Department of Human Anatomy and Embryology, Legal Medicine and History of Medicine, Faculty of Medicine, University of Málaga, 29071 Malaga, Spain
Interests: cardiovascular developmental; epicardium; vasculogenesis; myocardium
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Department of Human Anatomy and Embryology, Faculty of Medicine, Institute of Molecular Pathology Biomarkers, University of Extremadura, 06006 Badajoz, Spain
Interests: cardiovascular development; gastrulation; gene expression patterns; microRNAs; signaling pathways; experimental models
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Special Issue Information

Dear Colleagues,

Over the last few decades, we have witnessed a tremendous effort to understand the molecular and morphogenetic mechanisms driving cardiovascular development. At early developmental stages, the cardiac tube is constituted by two layers: the endocardium and the myocardium. Soon after cardiac looping, a third layer is formed, the epicardium, establishing critical contribution and crosstalk with the primordial cardiac layers, which might compromise coronary vascular formation and myocardial thickening if impaired. Therefore, the epicardium, besides just externally covering the naked myocardium, is primordial in disease progression, including those apparently further apart pathologies such as atrial fibrillation. More recently, a role in cardiac regeneration has also been widely acclaimed in distinct experimental models.

This Special Issue aims to cover studies on the molecular and functional roles of the epicardium in the cardiovascular system, spanning from the early stages of development to the adult heart, including cardiovascular physiopathological conditions and cardiac regeneration. Potential topics include, but are not limited to: proepicardium/epicardium development, transcriptional regulation of proepicardium/epicardium formation, post-transcriptional regulation of proepicardium/epicardium formation, epigenetics of epicardial development, single-cell analyses of epicardial cell diversification, contribution of the epicardium to cardiac diseases, and the role of epicardium in cardiac regeneration.

You may choose our Joint Special Issue in Hearts.

Prof. Dr. Diego Franco Jaime
Dr. Rita Carmona
Dr. Carmen Lopez-Sanchez
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Cardiovascular Development and Disease is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transcriptional regulation
  • post-transcriptional regulation
  • epigenetic
  • epicardium
  • proepicardium
  • cardiac disease
  • cardiac regeneration

Published Papers (2 papers)

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Review

14 pages, 828 KiB  
Review
Novel Insights into the Molecular Mechanisms Governing Embryonic Epicardium Formation
by Rita Carmona, Carmen López-Sánchez, Virginio Garcia-Martinez, Virginio Garcia-López, Ramón Muñoz-Chápuli, Estefanía Lozano-Velasco and Diego Franco
J. Cardiovasc. Dev. Dis. 2023, 10(11), 440; https://doi.org/10.3390/jcdd10110440 - 24 Oct 2023
Viewed by 1724
Abstract
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the subepicardial space and thereafter [...] Read more.
The embryonic epicardium originates from the proepicardium, an extracardiac primordium constituted by a cluster of mesothelial cells. In early embryos, the embryonic epicardium is characterized by a squamous cell epithelium resting on the myocardium surface. Subsequently, it invades the subepicardial space and thereafter the embryonic myocardium by means of an epithelial–mesenchymal transition. Within the myocardium, epicardial-derived cells present multilineage potential, later differentiating into smooth muscle cells and contributing both to coronary vasculature and cardiac fibroblasts in the mature heart. Over the last decades, we have progressively increased our understanding of those cellular and molecular mechanisms driving proepicardial/embryonic epicardium formation. This study provides a state-of-the-art review of the transcriptional and emerging post-transcriptional mechanisms involved in the formation and differentiation of the embryonic epicardium. Full article
(This article belongs to the Special Issue The Epicardium: Development, Pathology, and Regeneration)
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14 pages, 735 KiB  
Review
Understanding Epicardial Cell Heterogeneity during Cardiogenesis and Heart Regeneration
by Cristina Sanchez-Fernandez, Lara Rodriguez-Outeiriño, Lidia Matias-Valiente, Felicitas Ramírez de Acuña, Diego Franco and Amelia Eva Aránega
J. Cardiovasc. Dev. Dis. 2023, 10(9), 376; https://doi.org/10.3390/jcdd10090376 - 1 Sep 2023
Cited by 1 | Viewed by 1378
Abstract
The outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the adult epicardium [...] Read more.
The outermost layer of the heart, the epicardium, is an essential cell population that contributes, through epithelial-to-mesenchymal transition (EMT), to the formation of different cell types and provides paracrine signals to the developing heart. Despite its quiescent state during adulthood, the adult epicardium reactivates and recapitulates many aspects of embryonic cardiogenesis in response to cardiac injury, thereby supporting cardiac tissue remodeling. Thus, the epicardium has been considered a crucial source of cell progenitors that offers an important contribution to cardiac development and injured hearts. Although several studies have provided evidence regarding cell fate determination in the epicardium, to date, it is unclear whether epicardium-derived cells (EPDCs) come from specific, and predetermined, epicardial cell subpopulations or if they are derived from a common progenitor. In recent years, different approaches have been used to study cell heterogeneity within the epicardial layer using different experimental models. However, the data generated are still insufficient with respect to revealing the complexity of this epithelial layer. In this review, we summarize the previous works documenting the cellular composition, molecular signatures, and diversity within the developing and adult epicardium. Full article
(This article belongs to the Special Issue The Epicardium: Development, Pathology, and Regeneration)
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