Vitamin D and Inflammatory Diseases
A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".
Deadline for manuscript submissions: closed (30 March 2021) | Viewed by 332
Special Issue Editors
Interests: vascular inflammation; immunomodulation; remodeling; thrombosis; atherosclerosis; neoangiogenesis
Special Issues, Collections and Topics in MDPI journals
Interests: inflammation; tumorigenesis; esophageal cancer; molecular pathways; targeted therapy
Special Issue Information
Dear Colleagues,
Vitamin D, “the Sun Vitamin”, is a steroid with hormone-like activity. Vitamin D deficiency is a global health problem. An estimated one billion people worldwide are vitamin D-deficient, while 50% of the population has vitamin D insufficiency. The reported prevalence of vitamin D deficiency among the adult population is nearly 14–59%, with a higher prevalence in Asian countries and countries with less sunlight during long winters. Vitamin D regulates the functions of over 200 genes and is essential for growth and development. Beyond its critical function in calcium homeostasis, vitamin D also plays an important role in the modulation of the immune system and inflammation via regulating the production of inflammatory cytokines and inhibiting the proliferation of pro-inflammatory cells. The association of vitamin D deficiency with chronic inflammatory diseases—including atherosclerosis-related cardiovascular disease, asthma, inflammatory bowel disease, chronic kidney disease, and nonalcoholic fatty liver disease—tumorigenesis, an increased risk of osteoporosis and rickets, and an unfavorable outcome of acute infections suggests a pleiotropic role of this vitamin in the pathogenesis of these diseases. Further, vitamin D supplementation bolsters clinical responses to acute infection, and research studies suggest its beneficial effects on chronic inflammatory diseases. It should also be noted that vitamin D has a dose-dependent effect, and an overdose might not be beneficial for patients suffering from inflammatory bowel disease, liver disease, or cystic fibrosis, who might have trouble absorbing vitamin D. Thus, further research on the role of vitamin D supplementation and the dose-dependent effects of vitamin D in inflammatory diseases is warranted.
This Special Issue of the International Journal of Environmental Research and Public Health (IJERPH) focuses on the association of vitamin D deficiency with acute and chronic inflammatory diseases and on the effects of vitamin D supplementation. Manuscripts (research articles, reviews, brief reports) investigating or discussing the effects of vitamin D deficiency and supplementation are welcome.
Dr. Vikrant Rai
Dr. Swati Agrawal
Guest Editors
Manuscript Submission Information
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Keywords
- vitamin D deficiency
- inflammation
- immunomodulation
- inflammatory cytokines
- chronic inflammatory diseases
- cardiovascular diseases
- musculoskeletal diseases
- cancers
- vitamin D supplementation
