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Diabetes Complications—from Childhood to Elderly—Diagnostics, Prevention, and Treatment

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (7 April 2023) | Viewed by 2534

Special Issue Editor


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Guest Editor
Department of Endocrinology and Diabetology, The Children’s Memorial Health Institute, Aleja Dzieci Polskich 20, 04-730 Warsaw, Poland
Interests: type 1 diabetes; diabetic neuropathy; diabetic retinopathy; children; diabetes therapy; diabetes complications; diabetes treatment; continuos glucose monitoring systems; body mass index; diabetes; obesity; insulintherapy; obesity prevention; pediatrics

Special Issue Information

Dear Colleagues, 

Diabetes is burdened by the risk of micro- and macrovascular complications. The International Diabetes Federation estimates that 425 million people worldwide have diabetes, making it the largest global epidemic of the 21st century. About USD 727 billion is directed toward diabetes and its complications, and this cost is increasing persistently and at an unsustainable rate. 

Diabetes complications were mostly observed in older people in the past; however, as more and more people are diagnosed with type 2 diabetes and type 1 diabetes diagnosis is happening at younger and younger ages, it is reasonable to expect that this pattern will change, with complications now being observed among younger patients. 

Diabetic retinopathy, nephropathy, and neuropathy are particularly disabling and silently developing complications. The lack of effective treatment highlights the importance of early diagnosis to prevent progression. Despite many initiatives and programs, healthcare systems are still ineffective as the global population of patients requiring different forms of life saving renal replacement therapy is growing fast, with foot ulceration frequently necessitating amputation and various patients suffering from blindness as a result of their disease. This has a significant impact on the socioeconomic situation of nations around the world as the aim is to provide equal and unlimited access to effective treatment. There is thus need for global cooperation and various possible interventions to solve this problem. 

The Special Issue will serve as a platform to publish results of primarily international and multidisciplinary research groups on different aspects of diabetes complications.

Dr. Marta Wysocka-Mincewicz
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetes mellitus complications
  • diabetic retinopathy
  • diabetic nephropathy
  • diabetic neuropathy
  • diabetic foot
  • prevention of diabetes complication
  • early diagnostic of diabetes complications
  • diabetes complications preventive programs
  • epidemiology
  • social economic and environmental impact
  • quality of life

Published Papers (1 paper)

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Research

16 pages, 1395 KiB  
Article
How Diabetes and Other Comorbidities of Elderly Patients and Their Treatment Influence Levels of Glycation Products
by Aleksandra Kuzan, Emilia Królewicz, Irena Kustrzeba-Wójcicka, Karolina Lindner-Pawłowicz and Małgorzata Sobieszczańska
Int. J. Environ. Res. Public Health 2022, 19(12), 7524; https://doi.org/10.3390/ijerph19127524 - 20 Jun 2022
Cited by 2 | Viewed by 2099
Abstract
Medical care for geriatric patients is a great challenge, mainly due to various overlapping deficits relevant to numerous coexisting diseases, of which the most common are diabetes mellitus and atherosclerosis. In the case of diabetes, the glycation process is intensified, which accelerates atherosclerosis [...] Read more.
Medical care for geriatric patients is a great challenge, mainly due to various overlapping deficits relevant to numerous coexisting diseases, of which the most common are diabetes mellitus and atherosclerosis. In the case of diabetes, the glycation process is intensified, which accelerates atherosclerosis development and diabetic complications. Our goal was to investigate the relationship between the classical biochemical parameters of diabetes and atherosclerosis, as well as parameters which may indicate a nephropathy, and the parameters strictly related to glycation, taking into account the pharmacological treatment of patients. Methods: We analyzed the patients’ serum concentrations of fluorescent glycation product—pentosidine, concentrations of soluble receptors for advanced glycation products (sRAGE), lipoprotein receptor-1 (LOX-1), galectin 3 (GAL3), scavenger receptor class A (SR-A), and scavenger receptor class B (SR-BI), as well as the level of lipid peroxidation and free amine content. Among the identified correlations, the most interesting are the following: sRAGE with triglycerides (r = 0.47, p = 0.009), sRAGE with SR-BI (r = 0.47, p = 0.013), SR-BI with LOX-1 (r = 0.31, p = 0.013), and SR-BI with HDL (r = −0.30, p = 0.02). It has been shown that pentosidine and reactive free amine contents are significantly higher in elderly patients with ischemic heart disease. Pentosidine is also significantly higher in patients with arterial hypertension. Malondialdehyde turned out to be higher in patients with diabetes mellitus type 2 that was not treated with insulin or metformin than in those treated with both medications (p = 0.052). GAL3 was found to be lower both in persons without diabetes and in diabetics treated with metformin (p = 0.005). LOX-1 was higher in diabetic patients not treated with metformin or insulin, and lowest in diabetics treated with both insulin and metformin, with the effect of metformin reducing LOX-1 levels (p = 0.039). Our results were the basis for a discussion about the diagnostic value in the clinical practice of LOX-1 and GAL3 in geriatric patients with diabetes and also provide grounds for inferring the therapeutic benefits of insulin and metformin treatment. Full article
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