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Prof. Dr. Kristina Selthofer-Relatić

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Guest Editor

Department for Cardiovascular Disease, University Hospital Osijek, J. Huttlera 4, HR-31000 Osijek, Croatia
Interests: cardiovascular diseases related to metabolic and other causes

Dr. Lana Maričić

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Guest Editor

Osijek University Hospital Centre, Josipa Huttlera 4, 31000 Osijek, Croatia
Interests: cardiovascular diseases related to metabolic and other causes

Special Issue Information

Dear Colleagues,

Obesity and diabetes are the most common causes of atherosclerotic vascular disease of the coronary, cerebral and peripheral arteries of the lower extremities, arterial hypertension, dyslipidemia and consequent heart failure in various types of cardiomyopathies with a preserved, mildly reduced or reduced ejection fraction of the left ventricle.

Obesity and diabetes per se represent a major global health problem. If we count the number of patients with related cardiovascular comorbidities, then we must be aware of the complexity of the disease and the number of patients we encounter in daily clinical practice. In order to be aware and act, we need additional knowledge and understanding of the connection between obesity and diabetes mellitus and cardiovascular diseases.

Prof. Dr. Kristina Selthofer-Relatić
Dr. Lana Maričić
Guest Editors

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Keywords

cardiovascular diseases
diabetes mellitus
obesity

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Research

19 pages, 1703 KiB

Open AccessArticle

The Relationship of Left Ventricular Diastolic Dysfunction and Asymmetrical Dimethylarginine as a Biomarker of Endothelial Dysfunction with Cardiovascular Risk Assessed by Systematic Coronary Risk Evaluation2 Algorithm and Heart Failure—A Cross-Sectional Study

by Livija Sušić, Lana Maričić, Ines Šahinović, Kristina Kralik, Lucija Klobučar, Mateja Ćosić, Tihomir Sušić, Josip Vincelj, Antonio Burić, Marko Burić and Matea Lukić

Int. J. Environ. Res. Public Health 2023, 20(5), 4433; https://doi.org/10.3390/ijerph20054433 - 01 Mar 2023

Cited by 1 | Viewed by 1352

Abstract

Background: Cardiovascular (CV) risk factors, causing endothelial dysfunction (ED) and left ventricular diastolic dysfunction (LVDD), contribute to an increased risk of heart failure (HF). The aim of this study was to determine the relationship between the occurrence of LVDD and ED with CV risk assessed by the Systematic Coronary Risk Evaluation2 (SCORE2) algorithm and HF. Methods: In the period from November 2019 to May 2022, a cross-sectional study that included 178 middle-aged adults was conducted. Transthoracic echocardiography (TTE) was used to assess left ventricular (LV) diastolic and systolic function. ED was assessed using the plasma values of asymmetric dimethylarginine (ADMA) and was determined using the ELISA method. Results: The majority of subjects with LVDD grades 2 and 3 had high/very high SCORE2, developed HF and all were taking medication (p < 0.001). They also had significantly lowest plasma ADMA values (p < 0.001). We found that the reduction of ADMA concentration is influenced by certain groups of drugs, or more significantly, by their combinations (p < 0.001). Conclusions: In our study, we confirmed a positive correlation between LVDD, HF and SCORE2 severity. The results showed a negative correlation between the biomarkers of ED, LVDD severity, HF, and SCORE2, which we believe is due to medication effects. Full article

(This article belongs to the Special Issue Global Pandemics Interconnected — Obesity, Cardiovascular Disease and Diabetes)

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