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The Contributing Role of Clinical Neurophysiology in Public Health

A special issue of International Journal of Environmental Research and Public Health (ISSN 1660-4601). This special issue belongs to the section "Health Behavior, Chronic Disease and Health Promotion".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3043

Special Issue Editors


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Guest Editor
Neurophysiopathology Unit, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy
Interests: clinical neurophysiology; neuromonitoring and neuromodulation; neurological disorders; pathophysiology of nervous system

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Guest Editor
Clinical and Experimental Epileptology and Sleep Disorders Unit, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy
Interests: epilepsy; epilepsy surgery; autoimmune epilepsy; sleep disorders

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Guest Editor
Neurophysiopathology Department and Epilepsy Centre, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy
Interests: disorders of consciousness; functional neuroimaging; magnetoencephalography; transcranial magnetic stimulation

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Guest Editor
Neurophysiology Unit, Foundation IRCCS Carlo Besta Neurological Institute, 20133 Milan, Italy
Interests: neurophysiology; neuropathic pain; neuromuscular disease; peripheral neuropathy

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Guest Editor
Department of Neuroscience, Rehabilitation, Ophthalmology, Genetics and Maternal/Child Sciences, University of Genoa, 16132 Genoa, Italy
Interests: neurophysiology of sleep; stress-sleep relationship; psychopathology; mental health; suicide
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Special Issue Information

Dear Colleagues,

There is ample evidence that pinpoints neurological disorders as one of the greatest threats to public health. Neurological disorders and their sequelae are currently estimated to affect as many as a billion people worldwide. These disorders are found among all age groups and in all geographical regions. Because most of the neurological disorders result in long-term disability and many have an early age of onset, measures of prevalence and mortality vastly understate the disability they cause. There are several gaps in understanding the many issues related to neurological disorders. This Special Issue focuses on “The Contributing Role of Clinical Neurophysiology in Public Health” and invites neurophysiological investigations of the central or peripheral nervous system or muscle in healthy humans or patients with neuromuscular or autonomic diseases, pain, movement disorders, demyelinating diseases, sleep disorders, headache, dementia, epilepsy, neurological disorders associated with malnutrition, stroke, and brain injuries.

The clinical neurophysiology takes advantage of multiple procedures for nervous system structure and function, from molecular to behavioral levels of inquiry, including electro- or magnetoencephalography; electromyography and nerve conduction studies; single fiber EMG; surface EMG patterns; nerve and muscle ecography; evoked potentials, event-related potentials, and polysomnography; deep brain stimulators; invasive and non-invasive neuromodulation; and intraoperative neuromonitoring. The techniques and knowledge of clinical neurophysiology by optimizing neurologic health might contribute to the improvement of public health through preventing, screening, diagnosis, and monitoring neurological diseases and modulating neurological injuries.

Dr. Paola Lanteri
Dr. Giuseppe Didato
Dr. Davide Rossi Sebastiano
Dr. Daniele Cazzato
Dr. Sergio Garbarino
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Environmental Research and Public Health is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2500 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neuromuscular diseases
  • neurological disorders
  • brain injuries
  • sleep disorders
  • epilepsy
  • pain
  • neuromonitoring
  • neuromodulation
  • clinical neurophysiology
  • performance
  • cognitive behavioral assessment

Published Papers (1 paper)

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Research

10 pages, 3128 KiB  
Article
In Vitro and In Vivo Effects of Nobiletin on DRG Neurite Elongation and Axon Growth after Sciatic Nerve Injury
by Tae-Beom Seo, Yoon-A Jeon, Sang Suk Kim and Young Jae Lee
Int. J. Environ. Res. Public Health 2021, 18(17), 8988; https://doi.org/10.3390/ijerph18178988 - 26 Aug 2021
Cited by 2 | Viewed by 2310
Abstract
Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Thus, the purpose of this study was to investigate whether [...] Read more.
Sciatic nerve injury (SNI) leads to sensory and motor dysfunctions. Nobiletin is a major component of polymethoxylated flavonoid extracted from citrus fruits. The role of nobiletin on sciatic nerve regeneration is still unclear. Thus, the purpose of this study was to investigate whether nobiletin increases DRG neurite elongation and regeneration-related protein expression after SNI. Cytotoxicity of nobiletin was measured in a concentration–dependent manner using the MTT assay. For an in vitro primary cell culture, the sciatic nerve on the middle thigh was crushed by holding twice with forceps. Dorsal root ganglion (DRG) and Schwann cells were cultured 3 days after SNI and harvested 36 h later and 3 days later, respectively. In order to evaluate specific regeneration-related markers and axon growth in the injured sciatic nerve, we applied immunofluorescence staining and Western blot techniques. Nobiletin increased cell viability in human neuroblastoma cells and inhibited cytotoxicity induced by exposure to H2O2. Mean neurite length of DRG neurons was significantly increased in the nobiletin group at a dose of 50 and 100 μM compared to those at other concentrations. GAP-43, a specific marker for axonal regeneration, was enhanced in injury preconditioned Schwann cells with nobiletin treatment and nobiletin significantly upregulated it in injured sciatic nerve at only 3 days post crush (dpc). In addition, nobiletin dramatically facilitated axonal regrowth via activation of the BDNF-ERK1/2 and AKT pathways. These results should provide evidence to distinguish more accurately the biochemical mechanisms regarding nobiletin-activated sciatic nerve regeneration. Full article
(This article belongs to the Special Issue The Contributing Role of Clinical Neurophysiology in Public Health)
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