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Healthcare
Special Issues
2nd Edition of Neurorehabilitation: Looking Back and Moving Forward
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2nd Edition of Neurorehabilitation: Looking Back and Moving Forward

A special issue of Healthcare (ISSN 2227-9032).

Deadline for manuscript submissions: closed (19 December 2022) | Viewed by 5434

Special Issue Editors

Dr. Grigorios Nasios

E-Mail Website
Guest Editor
Department of Speech and Language Therapy, School of Health Sciences, University of Ioannina, 451 10 Ioannina, Greece
Interests: cognitive and behavioral neurology; neurorehabilitation; multiple sclerosis; dementias; cognitive communication disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Lambros Messinis

E-Mail Website
Guest Editor
1. Neuropsychology Section, Department of Psychiatry, University of Patras Medical School, Rio 265 04, Greece
2. Laboratory of Cognitive Neuroscience, School of Psychology, Aristotle University of Thessaloniki, Thessaloniki 541 24, Greece
Interests: clinical neuropsychology; cognitive/neuropsychological rehabilitation; cognitive neuroscience; multiple sclerosis; cognitive communication disorders
Special Issues, Collections and Topics in MDPI journals
Dr. Efthimios Dardiotis

E-Mail Website
Guest Editor
1. Department of Neurology, Laboratory of Neurogenetics, University Hospital of Larissa, 41110 Larissa, Greece
2. School of Medicine, University of Thessaly, 41110 Larissa, Greece
Interests: neurosciences; neurology; neurogenetics; molecular neurology; cognitive impairment; neurorehabilitation
Special Issues, Collections and Topics in MDPI journals
Dr. Markos Sgantzos

E-Mail Website
Guest Editor
Department of Anatomy, Faculty of Medicine, University of Thessaly, 382 21 Larissa, Greece
Interests: rehabilitation medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Neurorehabilitation is a complex, medically driven set of therapeutic targeted actions applied to persons who live with neurological diseases, in order to restore and/or compensate for their disabilities. Over the years, the progress made in neurorehabilitation has been impressive, especially during the last two decades. These advances followed the progress of clinical neurosciences in general, which is accelerated by a number of factors, with technology being a major factor. Looking back, we are satisfied by the transition from experienced-based, empirical neurorehabilitation to an era of evidence-based practice, in which multidisciplinary approaches and translational research are applied worldwide, even from the acute phase, throughout the disease courses of an increasing number of people who require treatment. However, despite this progress, there are still many limitations and restrictions. Nervous system damage frequently poses challenging recovery issues, and research still has much to clarify regarding the nervous system neuroplasticity and reorganization dynamics. Additionally, 

more treatment approaches and combinations of therapeutic interventions need to be standardized, offered on a widespread basis, and individualized by a new generation of influential and skilled clinical neuroscientists, physicians, neuroradiologists, neuropsychologists, and other therapists. Furthermore, these interventions must be organized under a fresh “patient-centric” approach, with home-based and tele-rehabilitation protocols replacing long stays in medical centers. In other words, we must move forward to a new era, where advances in medicine, basic research, engineering and high technology can develop more efficacious approaches, which can be widely applied to all people who need them.

In this Special Issue of Healthcare, we welcome empirical, clinical, and basic research and review papers covering the whole range of neurorehabilitation. Emphasis will be given, among others, to new technologies, cognitive rehabilitation, cognitive communication disorders (as a target of, but also as a hurdle to, rehabilitation), tele-rehabilitation approaches, the role of neuroimaging in designing and conducting relevant interventions, and mainly non-invasive neuromodulation techniques (such as repetitive transcranial magnetic stimulation and transcranial direct current stimulation).  

Dr. Grigorios Nasios
Dr. Lambros Messinis
Dr. Efthimios Dardiotis
Dr. Markos Sgantzos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Healthcare is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • neurorehabilitation
  • neuropsychological rehabilitation
  • stroke
  • multiple sclerosis
  • neurocognitive disorders
  • traumatic brain injury
  • neuromodulation
  • cognitive communication disorders
  • tele-rehabilitation
  • neuroimaging in neurorehabilitation

Related Special Issue

Published Papers (3 papers)

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Research

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13 pages, 1555 KiB  
Article
Computer-Based Cognitive Training vs. Paper-and-Pencil Training for Language and Cognitive Deficits in Greek Patients with Mild Alzheimer’s Disease: A Preliminary Study
by Eleni-Nefeli Georgopoulou, Anastasia Nousia, Vasileios Siokas, Maria Martzoukou, Elli Zoupa, Lambros Messinis, Efthimios Dardiotis and Grigorios Nasios
Healthcare 2023, 11(3), 443; https://doi.org/10.3390/healthcare11030443 - 03 Feb 2023
Cited by 1 | Viewed by 1699
Abstract
The purpose of the present study was to explore whether Computer-Based Cognitive Training (C-BCT) versus Paper-Pencil Cognitive Training (P-PCT) is more beneficial in improving cognitive and language deficits in Greek patients living with Alzheimer’s disease (pwAD). Twenty pwAD were assigned to two groups: [...] Read more.
The purpose of the present study was to explore whether Computer-Based Cognitive Training (C-BCT) versus Paper-Pencil Cognitive Training (P-PCT) is more beneficial in improving cognitive and language deficits in Greek patients living with Alzheimer’s disease (pwAD). Twenty pwAD were assigned to two groups: (a) the C-BCT group, receiving a computer-based cognitive training program using the RehaCom software, and (b) the P-PCT group, which received cognitive training using paper and pencil. The cognitive training programs lasted 15 weeks and were administered twice a week for approximately one hour per session. The analyses of each group’s baseline versus endpoint performance demonstrated that the P-PCT group improved on delayed memory, verbal fluency, attention, processing speed, executive function, general cognitive ability, and activities of daily living. In contrast, the C-BCT group improved on memory (delayed and working), naming, and processing speed. Comparisons between the two groups (C-BCT vs. P-PCT) revealed that both methods had significant effects on patients’ cognition, with the P-PCT method transferring the primary cognitive benefits to real-life activities. Our findings indicate that both methods are beneficial in attenuating cognitive and language deficits in pwAD. The need for large-scale neurobehavioral interventions to further clarify this issue, however, remains a priority. Full article
(This article belongs to the Special Issue 2nd Edition of Neurorehabilitation: Looking Back and Moving Forward)
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Review

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15 pages, 291 KiB  
Review
Targeting Cerebellum with Non-Invasive Transcranial Magnetic or Current Stimulation after Cerebral Hemispheric Stroke—Insights for Corticocerebellar Network Reorganization: A Comprehensive Review
by Eleni Aikaterini Ntakou, Grigorios Nasios, Anastasia Nousia, Vasileios Siokas, Lambros Messinis and Efthimios Dardiotis
Healthcare 2022, 10(12), 2401; https://doi.org/10.3390/healthcare10122401 - 29 Nov 2022
Cited by 2 | Viewed by 1671
Abstract
Non-invasive brain stimulation (NIBS) has emerged as one of the methods implemented in stroke rehabilitation. Cerebellar stimulation has gained research interest as an alternative strategy to cortical stimulation, based on the role of the cerebellum and corticocerebellar tracts in different motor and cognitive [...] Read more.
Non-invasive brain stimulation (NIBS) has emerged as one of the methods implemented in stroke rehabilitation. Cerebellar stimulation has gained research interest as an alternative strategy to cortical stimulation, based on the role of the cerebellum and corticocerebellar tracts in different motor and cognitive functions. This review investigates the role of the cerebellum in motor and cognitive rehabilitation following cerebral stroke using NIBS techniques combined with other therapies (e.g., speech or physical therapy). Fifteen randomized clinical trials were included. The majority of the literature findings point towards the cerebellum as a promising neurostimulation target following stroke of the cerebral cortex. Findings concern mostly rehabilitation of gait and balance, where cathodal transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) of the contralesional cerebellar hemisphere produce, in the presented clinical sample, improved performance and plasticity changes in the corticocerebellar network, combined with other rehabilitation methods. Data regarding aphasia rehabilitation are scarce, with right cerebellar tDCS exercising some impact in individual linguistic functions combined with language therapy. Based on recent data concerning cerebellar functions and corticocerebellar networks, along with the development of clinical protocols regarding non-invasive cerebellar (NICS) application, the cerebellum can prove a crucial intervention target in rehabilitation following stroke. Full article
(This article belongs to the Special Issue 2nd Edition of Neurorehabilitation: Looking Back and Moving Forward)

Other

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18 pages, 1805 KiB  
Systematic Review
A Comprehensive Appraisal of Meta-Analyses of Exercise-Based Stroke Rehabilitation with Trial Sequential Analysis
by Jia-Qi Li, Yu-Wei Sun, Wing-Sam So, Ananda Sidarta and Patrick Wai-Hang Kwong
Healthcare 2022, 10(10), 1984; https://doi.org/10.3390/healthcare10101984 - 10 Oct 2022
Cited by 1 | Viewed by 1488
Abstract
Meta-analysis is a common technique used to synthesise the results of multiple studies through the combination of effect size estimates and testing statistics. Numerous meta-analyses have investigated the efficacy of exercise programmes for stroke rehabilitation. However, meta-analyses may also report false-positive results because [...] Read more.
Meta-analysis is a common technique used to synthesise the results of multiple studies through the combination of effect size estimates and testing statistics. Numerous meta-analyses have investigated the efficacy of exercise programmes for stroke rehabilitation. However, meta-analyses may also report false-positive results because of insufficient information or random errors. Trial sequential analysis (TSA) is an advanced technique for calculating the required information size (RIS) and more restrictive statistical significance levels for the precise assessment of any specific treatment. This study used TSA to examine whether published meta-analyses in the field of stroke rehabilitation reached the RIS and whether their overall effect sizes were sufficient. A comprehensive search of six electronic databases for articles published before May 2022 was conducted. The intervention methods were divided into four primary groups, namely aerobic or resistance exercise, machine-assisted exercise, task-oriented exercise, and theory-based exercise. The primary outcome measure was gait speed and the secondary outcome measure was balance function. The data were obtained either from the meta-analyses or as raw data from the original cited texts. All data analysis was performed in TSA software. In total, 38 articles with 46 analysable results were included in the TSA. Only 17 results (37.0%) reached the RIS. In conclusion, meta-analysis interpretation is challenging. Clinicians must consider the RIS of meta-analyses before applying the results in real-world situations. TSA can provide accurate evaluations of treatment effects, which is crucial to the development of evidence-based medicine. Full article
(This article belongs to the Special Issue 2nd Edition of Neurorehabilitation: Looking Back and Moving Forward)
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