Dear Colleagues,

Oral health is a significant worldwide healthcare issue. It is closely associated with physical and psychological health of individuals, as well as the financial situation of families. Multiple diseases or disorders of the oral and maxillofacial system may lead to the loss of hard and soft tissues, which causes serious effects including stunting, mastication dysfunction and facial alteration. The most common chronic inflammation in craniofacial region, periodontitis and apical periodontitis, lead the loss of alveolar bone, resulting in maxillofacial bone defects and ultimately tooth loss. In addition, maxillofacial surgery, trauma, tumors and other diseases can also lead to bone defects. Due to the specific location, maxillofacial bone defects not only affects physiological functions but also have an impact on the patients' aesthetics. Yet, maxillofacial bone repair and regeneration is still an unsolved clinical challenge. Nowadays, various studies have focused on this field, such as through the use of stem cell therapy to promote bone regeneration, combined with innovative biomaterials to promote bone tissue healing. These methods have achieved remarkable results and are expected to provide new ideas for the clinical treatment of bone regeneration.

This Special Issue is looking for recent advances in oral health, particularly as regards the repair and regeneration of maxillofacial bone defects. Papers focused on tissue engineering, bone repairing and regeneration, stem cells and clinical application are especially welcome.

We hope this Special Issue could provide the latest views on promoting oral health and maxillofacial bone regeneration, discovering novel opinions on maxillofacial bone repair and regeneration and further exploring the intrinsic mechanisms.

Dr. Yi Fan
Guest Editor

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• oral health
• chronic inflammatory oral diseases
• clinical treatment
• maxillofacial system
• bone defects
• bone repairing
• bone regeneration
• tissue engineering
• stem cell
• mechanism
• therapeutic targets