Application of Electronic Health Records in Pharmacovigilance

A special issue of Healthcare (ISSN 2227-9032). This special issue belongs to the section "Medication Management".

Deadline for manuscript submissions: 30 September 2024 | Viewed by 834

Special Issue Editor


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Guest Editor
1. UCBL · Pharmacotoxicology and Neonatal Intensive Care Unit, University of Lyon 1, EMET, LBBE, UMR CNRS 5558, Villeurbanne, France
2. Laboratoire de Biométrie et Biologie Humaine, Équipe Évaluation et Modélisation des Effets Thérapeutiques, rue Guillaume-Paradin, BP8071, CEDEX 08, 69376 Lyon, France
Interests: application AI and automatic trigger tool in pharmacovigilance

Special Issue Information

Dear Colleagues,

Medicines and vaccines have transformed the prevention and treatment of diseases. In addition to their benefits, medicinal products may also have side effects, some of which may be undesirable and / or unexpected. Pharmacovigilance (PV) is the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other medicine/vaccine related problem (WHO).  Electronic health records (EHRs) has played an important role in pharmacovigilance. Nowadays, EHRs become a principal data source using in daily PV. Furthermore, artificial intelligence (AI) recently has emerged as a useful tool in pharmacovigilance.  AI could help in early detection and prevention of moderate and serious adverse drug reactions. However, there are a number of challenges that need to be addressed before AI can be fully adopted in this field. One of the challenge is how to use routine electronic health records with AI application in promoting pro-active monitoring of ADRs in clinical practice. This special issue aim to address the use of EHRs in PV.

We are pleased to invite you to contribute your research works related to innovated tools using EHRs in pharmacovigilance. 

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but not limited to) the following:

  1. Using EHRs in pharmacovigilance
  2. Implementation of automatic or semiautomatic trigger tool to detect ADRs using EHRs
  3. AI application in pharmacovigilance
  4. Active monitoring of adverse drug reactions using EHRs

Using trigger words in unstructured, narrative text to detect adverse drug reactions (ADRs).

I look forward to receiving your contributions.

Dr. Kim An Nguyen
Guest Editor

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Keywords

  • pharmacovigilance
  • drug-related side effects
  • adverse drug reactions
  • reporting systems
  • medical records systems
  • electronic health records
  • deep learning
  • machine learning
  • data mining
  • artificial intelligence.

Published Papers (1 paper)

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11 pages, 414 KiB  
Article
Unlicensed/Off-Label Drug Prescriptions at Hospital Discharge in Children: An Observational Study Using Routinely Collected Health Data
by Elham Jaberi, Inesse Boussaha, Xavier Dode, Guillaume Grenet, Behrouz Kassai and Kim An Nguyen
Healthcare 2024, 12(2), 208; https://doi.org/10.3390/healthcare12020208 - 15 Jan 2024
Viewed by 612
Abstract
Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children. Methods: We [...] Read more.
Background: Unlicensed and off-label (UL/OL) prescriptions have been associated with an increased risk of drug-related problems. Data of their prevalence at hospital discharge remain insufficient. We aimed to describe the prevalence of UL/OL drugs in outpatient prescriptions at discharge in children. Methods: We conducted a retrospective study using the routinely collected health data of children at discharge from 2014 to 2016. The primary reference source for determining licensed labelling was the summaries of product characteristics (SPCs) in a French industry-independent formulary named Thériaque. We described the characteristics of UL/OL prescriptions at discharge and looked for predictors of UL/OL prescriptions. Results: We included 2536 prescriptions of 479 children. Licensed, OL, and UL prescriptions accounted for 58.6% (95% CI: 56.7–60.5), 39.2% (95% CI: 37.3–41.1), and 2.3% (95% CI: 1.7–2.9), respectively. A total of 323 (74%) children received at least one UL/OL drug. Among the licensed drugs, bronchodilators (8.8%) and analgesics (8.6%), and among the OL drugs, antibiotics (2.8%), were the most prescribed. The younger age of the children and higher number of drugs they received increased the probability of UL/OL prescriptions (unadjusted p-value of ≤0.05). Conclusion: The prevalence of UL/OL prescriptions is about 40% at discharge from a pediatric university hospital in France. Full article
(This article belongs to the Special Issue Application of Electronic Health Records in Pharmacovigilance)
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