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Genes
Special Issues
Epigenomic Mechanisms in Neurodevelopment and Neurological Disorders
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Epigenomic Mechanisms in Neurodevelopment and Neurological Disorders

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Neurogenomics".

Deadline for manuscript submissions: closed (5 November 2022) | Viewed by 3936

Special Issue Editors

Prof. Dr. Zhao-Qian Teng

E-Mail Website
Guest Editor
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Interests: neurodegeneration; epigenetics; regenerative medicine; mental disorders
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Changmei Liu

E-Mail Website
Guest Editor
State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China
Interests: epigenetics; neurogenesis; neurodevelopment; regenerative medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epigenetic programming plays a pivotal role in the development and homeostasis of the nervous system. Dysregulation of the epigenome and epimutations are associated with the onset and progression of neurodevelopmental and neurological disorders, including autism spectrum disorder, epilepsy, schizophrenia, Alzheimer’s disease, and Parkinson’s disease. Despite numerous scientific breakthroughs over the last several decades, the treatment of neurodevelopmental and neurological disorders remains a great challenge.

This Special Issue welcomes critical reviews and high-quality original research articles dedicated to advances in our understanding of epigenomic mechanisms in neurodevelopment and neurological disorders. The proposed topics include, but are not limited to, epigenomic biomarkers for prognostication and diagnosis, new tools to understand or exploit epigenetic alterations, mechanisms of epigenome dysregulation, links between epimutations and the onset and progression of neurodevelopmental and neurological disorders, epigenome editing strategies, epigenetics-based therapies for neurodevelopmental and neurological disorders.

We look forward to reading your contributions.

Prof. Dr. Zhao-Qian Teng
Prof. Dr. Changmei Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenetics
  • neural development
  • autism spectrum disorders
  • epilepsy
  • schizophrenia
  • Alzheimer’s disease
  • Parkinson’s disease
  • neurological disorders

Published Papers (1 paper)

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Review

20 pages, 2205 KiB  
Review
Structural Insights and Development of LRRK2 Inhibitors for Parkinson’s Disease in the Last Decade
by Gunjan Thakur, Vikas Kumar, Keun Woo Lee and Chungkil Won
Genes 2022, 13(8), 1426; https://doi.org/10.3390/genes13081426 - 11 Aug 2022
Cited by 5 | Viewed by 3602
Abstract
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. The pathophysiology of PD is likely caused by a variety of environmental and hereditary factors. Many single-gene mutations have been linked to [...] Read more.
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease, characterized by the specific loss of dopaminergic neurons in the midbrain. The pathophysiology of PD is likely caused by a variety of environmental and hereditary factors. Many single-gene mutations have been linked to this disease, but a significant number of studies indicate that mutations in the gene encoding leucine-rich repeat kinase 2 (LRRK2) are a potential therapeutic target for both sporadic and familial forms of PD. Consequently, the identification of potential LRRK2 inhibitors has been the focus of drug discovery. Various investigations have been conducted in academic and industrial organizations to investigate the mechanism of LRRK2 in PD and further develop its inhibitors. This review summarizes the role of LRRK2 in PD and its structural details, especially the kinase domain. Furthermore, we reviewed in vitro and in vivo findings of selected inhibitors reported to date against wild-type and mutant versions of the LRRK2 kinase domain as well as the current trends researchers are employing in the development of LRRK2 inhibitors. Full article
(This article belongs to the Special Issue Epigenomic Mechanisms in Neurodevelopment and Neurological Disorders)
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