Genome and Epigenome of Fetal Alcohol Spectrum Disorders
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Human Genomics and Genetic Diseases".
Deadline for manuscript submissions: closed (26 February 2021) | Viewed by 6808
Special Issue Editor
Special Issue Information
Alcohol exposure during pregnancy often leads to a variety of birth defects and neurodevelopmental deficits referred to as fetal alcohol spectrum disorders (FASDs). These effects can have lifelong implications including physical, mental, behavioral, and/or learning issues. Not all embryos exposed to alcohol develop FASD syndromes after birth; some present severe birth defects, while others are normal in physical appearance but present a variety of cognitive and behavioral difficulties. Numerous variables may be involved in the outcomes of fetal alcohol exposures. Several recent studies have identified that genetics and epigenetics are important variables of phenotypic outcomes of fetal alcohol exposures.
In this volume, we plan to summarize the current research on genomic and epigenomic aspects of FASDs and discuss how this information can be useful in the early diagnosis and potential treatment of FASDs.
Topics of primary interest include, but are not limited to:
- Contribution of genetic and epigenetic mechanisms in FASD pathobiology;
- Role of non-protein-coding RNAs in FASDs;
- Gene-splicing and FASDs;
- Involvement of oxidative stress and DNA damage in FASD mechanisms;
- Circadian gene abnormalities in FASDs;
- Neuroimmune deficit and its impact on the development of fetal alcohol exposure (FAE)-induced social behavior deficit;
- Programming effects of fetal alcohol exposure across generations;
- Preconception alcohol effects on behaviors and health;
- Genetic approaches in early FASD diagnosis and potential treatment of the affected FASD individuals.
Prof. Dipak K. Sarkar
Guest Editor
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Keywords
- Fetal alcohol spectrum disorders (FASDs)
- Fetal alcohol exposure (FAE)
- Genetics
- Epigenetics
- Diagnosis
