Genotoxicity: Damage to DNA and Its Consequences
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (25 May 2023) | Viewed by 2180
Special Issue Editor
Special Issue Information
Dear Colleagues,
Genetic toxicology is a subspecialty of general toxicology that addresses the problems of toxicity to the DNA in cells. This toxicity results either from accidents during the normal chemical transactions of DNA, often during replication, or exposure to high-energy electromagnetic or particle radiation, or highly reactive chemicals in the environment. The need to evaluate the genotoxic potentials of xenobiotics has been necessitated by the fact that, each year, new chemical substances are being introduced into our environment and, in most cases, the consequences of human exposure to them are unknown. These agents can provoke genetic changes which may affect not only the present but also the future generation. Several studies have shown the possible pathways and mechanisms of induction of DNA damage. There are reports on individual substances’ or mixtures’ interactions with DNA. Likewise, biochemical and molecular mechanisms of genotoxicity have been extensively reported in the literature. In recent years, some medicinal plants have been shown to have both genotoxic and anti-genotoxic properties. DNA damage has dramatic short- and long-term consequences on the organism in which it occurs. As much as genomic changes have beneficial effects, they have also been implicated in the etiology of certain genetic disorders and cancer.
In this Special Issue, we are soliciting articles on genomic instability and the associated effects. Areas to be covered may include, but are not limited to, the following:
- Emerging contaminants and genetic change;
- Biochemical mechanism of genotoxicity;
- Genetic safety evaluation of herbal extracts;
- Molecular mechanism of genotoxicity;
- Genomic instability and carcinogenesis;
- DNA damage and cancer;
- Human health effects of genetic change;
- Endocrine disruptors and the DNA;
- Current approach in genotoxicity testing;
- Genotoxicity and epigenetics;
- Alternatives to laboratory animals in genotoxicity testing;
- DNA damage and repair;
- Genomic instability and gene expression analysis.
Prof. Dr. Adekunle Bakare
Guest Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
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mutagens
- carcinogens
- environmental DNA damage
- genetic diseases mechanisms of genotoxicity
- genoprotective substances
- gene expression
- public health effect
- toxicogenomics
