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Application of Animal Modeling in Cancer
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Application of Animal Modeling in Cancer

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".

Deadline for manuscript submissions: 25 June 2024 | Viewed by 2553

Special Issue Editors

Dr. Dongyu Jia

E-Mail Website
Guest Editor
Department of Molecular and Cellular Biology, Kennesaw State University, Kennesaw, GA, USA
Interests: cancer biology; human genetics; cell and molecular biology; drosophila
Dr. Yinu Wang

E-Mail Website
Guest Editor
Department of Obstetrics and Gynecology, Northwestern University, Chicago, IL, USA
Interests: ovarian cancer; cancer stem cell; epigenetics; metabolism; ROS; chemo resistance
Dr. Yoichiro Tamori

E-Mail Website
Guest Editor
Graduate School of Medicine, Kyoto University, Kyoto, Japan
Interests: cancer cell evolution; polyploidy; tissue homeostasis; morphogenesis

Special Issue Information

Dear Colleagues,

Cancer is essentially a genetic disease. Accumulated genetic mutations accelerate genome instability, which eventually leads to the uncontrollable growth of the tumor. Many cancer types have poor prognosis due to their clinical heterogeneity and molecular diversity. There is a great need to understand cancer biology and to create animal models to advance scientific knowledge and facilitate cancer treatments.

This Special Issue of Genes aims to highlight the most recent advances in animal modeling and its application in the field of cancer research. We invite authors to submit reviews, original articles, new experimental and computational methods, and commentaries that focus on any of the following topics: different animal models of cancer, applications of animal modeling, and translational research using animals in cancer research and the clinical field. We look forward to your contributions.

Dr. Dongyu Jia
Dr. Yinu Wang
Dr. Yoichiro Tamori
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal model
  • cancer model
  • application
  • translational research
  • cancer biology

Published Papers (2 papers)

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Research

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21 pages, 1810 KiB  
Article
Translation of Data from Animal Models of Cancer to Immunotherapy of Breast Cancer and Chronic Lymphocytic Leukemia
by Reginald Gorczynski
Genes 2024, 15(3), 292; https://doi.org/10.3390/genes15030292 - 25 Feb 2024
Viewed by 744
Abstract
The field of clinical oncology has been revolutionized over the past decade with the introduction of many new immunotherapies the existence of which have depended to a large extent on experimentation with both in vitro analysis and the use of various animal models, [...] Read more.
The field of clinical oncology has been revolutionized over the past decade with the introduction of many new immunotherapies the existence of which have depended to a large extent on experimentation with both in vitro analysis and the use of various animal models, including gene-modified mice. The discussion below will review my own laboratory’s studies, along with those of others in the field, on cancer immunotherapy. Our own studies have predominantly dwelt on two models of malignancy, namely a solid tumor model (breast cancer) and lymphoma. The data from our own laboratory, and that of other scientists, highlights the novel information so obtained, and the evidence that application of such information has already had an impact on immunotherapy of human oncologic diseases Full article
(This article belongs to the Special Issue Application of Animal Modeling in Cancer)
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Review

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20 pages, 2111 KiB  
Review
Polyploid Cancer Cell Models in Drosophila
by Yuqing Wang and Yoichiro Tamori
Genes 2024, 15(1), 96; https://doi.org/10.3390/genes15010096 - 14 Jan 2024
Viewed by 1431
Abstract
Cells with an abnormal number of chromosomes have been found in more than 90% of solid tumors, and among these, polyploidy accounts for about 40%. Polyploidized cells most often have duplicate centrosomes as well as genomes, and thus their mitosis tends to promote [...] Read more.
Cells with an abnormal number of chromosomes have been found in more than 90% of solid tumors, and among these, polyploidy accounts for about 40%. Polyploidized cells most often have duplicate centrosomes as well as genomes, and thus their mitosis tends to promote merotelic spindle attachments and chromosomal instability, which produces a variety of aneuploid daughter cells. Polyploid cells have been found highly resistant to various stress and anticancer therapies, such as radiation and mitogenic inhibitors. In other words, common cancer therapies kill proliferative diploid cells, which make up the majority of cancer tissues, while polyploid cells, which lurk in smaller numbers, may survive. The surviving polyploid cells, prompted by acute environmental changes, begin to mitose with chromosomal instability, leading to an explosion of genetic heterogeneity and a concomitant cell competition and adaptive evolution. The result is a recurrence of the cancer during which the tenacious cells that survived treatment express malignant traits. Although the presence of polyploid cells in cancer tissues has been observed for more than 150 years, the function and exact role of these cells in cancer progression has remained elusive. For this reason, there is currently no effective therapeutic treatment directed against polyploid cells. This is due in part to the lack of suitable experimental models, but recently several models have become available to study polyploid cells in vivo. We propose that the experimental models in Drosophila, for which genetic techniques are highly developed, could be very useful in deciphering mechanisms of polyploidy and its role in cancer progression. Full article
(This article belongs to the Special Issue Application of Animal Modeling in Cancer)
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