Gene Editing in Drosophila to Study Gene Function and Developmental Processes
A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Molecular Genetics and Genomics".
Deadline for manuscript submissions: closed (5 April 2024) | Viewed by 1732
Special Issue Editors
Interests: development; evolution; Drosophila; Notch signaling pathway; cell–cell communication
Special Issues, Collections and Topics in MDPI journals
Interests: genetics; gene regulation; Notch signaling; Drosophila; transcriptional super complexes
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
For decades, studies on gene function and developmental processes in Drosophila have been dependent on gene mutations, the phenotypic consequences of which have enabled the delineation of respective gene functions and the determination of their impact on developmental processes. Over time, tissue-specific overexpression techniques have been used to study the effects of ectopic gene expression, usually resulting in the opposite phenotype of the mutations. The most recent techniques for genome engineering, including CRISPR/Cas9 applications, now enable gene replacement at the endogenous locus, as well as precise gene editing. These techniques open the avenue to addressing many questions, including the precise structure–function relationships in single proteins or protein complexes, the impact of secondary modifications such as phosphorylation, and gene regulatory networks. In this way, Drosophila, as one of the best established model systems, may serve to address processes of medical importance and, eventually, to facilitate the development of new therapies.
This Special Issue will focus on the application of gene editing approaches to study gene function and developmental processes in Drosophila, with emphasis on medical applications. We welcome submissions of reviews, research articles, and short communications on related topics by 1 October 2023.
Dr. Dieter Maier
Dr. Anja C. Nagel
Guest Editors
Manuscript Submission Information
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Keywords
- Drosophila
- gene engineering
- CRISPR/Cas9
- developmental pathways
- in vivo functional analysis
- structure–function analyses
- gene networks
