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Epigenomics, Epigenetics, and Gene Expression Regulation as Determinants of Fat...
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Epigenomics, Epigenetics, and Gene Expression Regulation as Determinants of Fat Deposition and Adipogenesis in Mammals

A special issue of Genes (ISSN 2073-4425). This special issue belongs to the section "Epigenomics".

Deadline for manuscript submissions: closed (20 March 2024) | Viewed by 775

Special Issue Editors

Dr. Katarzyna Piórkowska

E-Mail Website
Guest Editor
Department of Animal Molecular Biology, National Research Institute of Animal Production, 31-047 Cracow, Poland
Interests: fat deposition; pig; lncRNA; adipogenesis; epigenomics; chickens; NGS
Special Issues, Collections and Topics in MDPI journals
Dr. Katarzyna Ropka-Molik

E-Mail Website
Guest Editor
Department of Animal Molecular Biology, National Research Institute of Animal Production, Krakowska Street 1, 31-083 Balice, Poland
Interests: epigenetics; animals; pigs; horses; transcriptomics; high-throughput NGS methods; molecular regulation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Epigenetics is a phenomenon that affects gene expression without altering the base pair sequence, and epigenomics is the study of epigenetic modifications to the entire genome. These studies attempt to indicate the relationship between genes and environmental conditions (diet, housing, feeding) to generate a phenotype. Some epigenetic information can be inherited across generations. The epigenetics mechanism and transcriptional regulatory events determine gene expression and activity during development in response to environmental and dietary stimuli. In the literature, there is evidence that obese people have significantly different epigenetic patterns compared to non-obese people. Therefore, the long-term target in this area is the identification of epigenetic marks that could be applied to predict metabolic syndrome risk early in order to delay and reverse these epigenetic changes. In turn, in farm animals, controlling fat deposition based on epigenetic modification is still scarcely investigated and knowledge in this area needs to be thoroughly broadened.

Our SI aims to collect interesting papers focusing on epigenetics regulation during adipogenesis, obesity, and fat deposition, determining processes in different kinds of species.

Dr. Katarzyna Piórkowska
Dr. Katarzyna Ropka-Molik
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Genes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • epigenomics
  • epigenetics modification
  • obesity
  • fat deposition
  • gene expression
  • regulation

Published Papers (1 paper)

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Review

17 pages, 1307 KiB  
Review
MALAT1: A Long Non-Coding RNA with Multiple Functions and Its Role in Processes Associated with Fat Deposition
by Katarzyna Piórkowska, Karolina Zygmunt, Walter Hunter and Ksenia Wróblewska
Genes 2024, 15(4), 479; https://doi.org/10.3390/genes15040479 - 10 Apr 2024
Viewed by 594
Abstract
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) belongs to the lncRNA molecules, which are involved in transcriptional and epigenetic regulation and the control of gene expression, including the mechanism of chromatin remodeling. MALAT1 was first discovered during carcinogenesis in lung adenocarcinoma, hence [...] Read more.
Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) belongs to the lncRNA molecules, which are involved in transcriptional and epigenetic regulation and the control of gene expression, including the mechanism of chromatin remodeling. MALAT1 was first discovered during carcinogenesis in lung adenocarcinoma, hence its name. In humans, 66 of its isoforms have been identified, and in pigs, only 2 are predicted, for which information is available in Ensembl databases (Ensembl Release 111). MALAT1 is expressed in numerous tissues, including adipose, adrenal gland, heart, kidney, liver, ovary, pancreas, sigmoid colon, small intestine, spleen, and testis. MALAT1, as an lncRNA, shows a wide range of functions. It is involved in the regulation of the cell cycle, where it has pro-proliferative effects and high cellular levels during the G1/S and mitotic (M) phases. Moreover, it is involved in invasion, metastasis, and angiogenesis, and it has a crucial function in alternative splicing during carcinogenesis. In addition, MALAT1 plays a significant role in the processes of fat deposition and adipogenesis. The human adipose tissue stem cells, during differentiation into adipocytes, secrete MALAT1 as one the most abundant lncRNAs in the exosomes. MALAT1 expression in fat tissue is positively correlated with adipogenic FABP4 and LPL. This lncRNA is involved in the regulation of PPARγ at the transcription stage, fatty acid metabolism, and insulin signaling. The wide range of MALAT1 functions makes it an interesting target in studies searching for drugs to prevent obesity development in humans. In turn, in farm animals, it can be a source of selection markers to control the fat tissue content. Full article
(This article belongs to the Special Issue Epigenomics, Epigenetics, and Gene Expression Regulation as Determinants of Fat Deposition and Adipogenesis in Mammals)
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