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Electronics
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Advanced Laser Technologies for Biophotonics
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Advanced Laser Technologies for Biophotonics

A special issue of Electronics (ISSN 2079-9292). This special issue belongs to the section "Bioelectronics".

Deadline for manuscript submissions: closed (30 June 2021) | Viewed by 7918

Special Issue Editors

Dr. Ekaterina Borisova

E-Mail Website
Guest Editor
Laboratory "Biophotonics"; Institute of Electronics Bulgarian Academy of Sciences 72, Tsarigradsko chaussee Blvd., 1784 Sofia, Bulgaria
Interests: biophotonics; fluorescence spectroscopy; diffuse-reflectance spectroscopy skin cancer diagnosis; gastrointestinal tract cancer diagnosis; photodynamic therapy; laser biostimulation
Dr. Luis Oliveira

E-Mail Website1 Website2
Guest Editor
1. Center of Innovation in Engineering and Industrial Technology, ISEP, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal
2. Physics Department, School of Engineering, Polytechnic Institute of Porto, Rua Dr. António Bernardino de Almeida 431, 4249-015 Porto, Portugal
Interests: biomedical optics; biophotonics; tissue optical clearing; optical methods for cancer detection; ultraviolet spectroscopy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Recently laser technologies have made a significant impact on biophotonics research and biomedical research, since they provide advanced minimally invasive, cost-effective and rapid techniques for diagnostics, monitoring and treatment of a variety of diseases. Medical devices utilizing minimally invasive laser technology are rapidly finding their way into the mainstream for early disease diagnosis and improved patient acceptance and comfort.

This Special Issue in Electronics will consider for publication reviews and original papers in all disciplines of lasers and photonics in biology and medicine applications. Entitled “Advanced Laser Technologies for Biophotonics”, it will provide a vehicle to help professionals, graduates, engineers, academics, and researchers working in the field of intelligent laser physics, electronics and biophotonics to disseminate information on state-of-the-art techniques.

We invite researchers to contribute original research articles as well as review articles to focused on advanced laser technologies for biophotonics applications. Submissions can focus on the research concept or applied research in topics including, but not limited to, the following:

  • In vitro and in vivo studies of tissue optical and structural properties using UV, visible and NIR spectroscopy
  • Laser-induced fluorescence and Raman spectroscopy of biological objects;
  • Polarization-sensitive techniques for biological sample examination;
  • Optical coherence tomography and elastography of biological tissues;
  • Confocal and nonlinear optical microscopy of cells;
  • Photoacoustic and Doppler tomography of biological objects;
  • Laser–biological matter interactions: principles and applications (hyperthermia, ablation, vaporization, etc.);
  • Low-level laser therapy—principles and applications;
  • Laser micro- and nanotechnologies in medicine and biophotonics;
  • Optical sensing of blood, microcirculation and laser speckle contrast imaging;
  • Tissue optical clearing;
  • Terahertz applications in biology and medicine.

Dr. Ekaterina Borisova
Dr. Luis Oliveira
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Electronics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • UV, visible, and NIR spectroscopy of biological tissues;
  • Laser-induced fluorescence spectroscopy of biological objects;
  • Raman spectroscopy of biological objects;
  • Polarization-sensitive tissue imaging;
  • Optical coherent tomography;
  • Optical coherent elastography of biological tissues;
  • Confocal fluorescent microscopy (CFM)l;
  • Two-photon fluorescence microscopy;
  • Nonlinear optical microscopy;
  • Photoacoustic imaging of biological objects;
  • Doppler tomography of biological objects;
  • Laser-induced tissue hyperthermia;
  • Laser ablation of biological tissues;
  • Low-level laser therapy;
  • Laser micro- and nanotechnologies in medicine and biophotonics;
  • Optical sensing of blood;
  • Laser Speckle contrast imaging;
  • Tissue optical clearing;
  • Terahertz imaging of biological objects;    

Published Papers (3 papers)

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Research

18 pages, 4978 KiB  
Article
Spatially-Resolved Multiply-Excited Autofluorescence and Diffuse Reflectance Spectroscopy: SpectroLive Medical Device for Skin In Vivo Optical Biopsy
by Walter Blondel, Alain Delconte, Grégoire Khairallah, Frédéric Marchal, Amélie Gavoille and Marine Amouroux
Electronics 2021, 10(3), 243; https://doi.org/10.3390/electronics10030243 - 21 Jan 2021
Cited by 14 | Viewed by 2313
Abstract
This contribution presents the development of an optical spectroscopy device, called SpectroLive, that allows spatially-resolved multiply-excited autofluorescence and diffuse reflectance measurements. Besides describing the device, this study aims at presenting the metrological and safety regulation validations performed towards its aimed application to skin [...] Read more.
This contribution presents the development of an optical spectroscopy device, called SpectroLive, that allows spatially-resolved multiply-excited autofluorescence and diffuse reflectance measurements. Besides describing the device, this study aims at presenting the metrological and safety regulation validations performed towards its aimed application to skin carcinoma in vivo diagnosis. This device is made of six light sources and four spectrometers for detection of the back-scattered intensity spectra collected through an optical probe (made of several optical fibers) featuring four source-to-detector separations (from 400 to 1000 µm). In order to be allowed by the French authorities to be evaluated in clinics, the SpectroLive device was successfully checked for electromagnetic compatibility and electrical and photobiological safety. In order to process spectra, spectral correction and metrological calibration were implemented in the post-processing software. Finally, we characterized the device’s sensitivity to autofluorescence detection: excitation light irradiance at the optical probe tip in contact with skin surface ranges from 2 to 11 W/m², depending on the light source. Such irradiances combined to sensitive detectors allow the device to acquire a full spectroscopic sequence within 6 s which is a short enough duration to be compatible with optical-guided surgery. All these results about sensitivity and safety make the SpectroLive device mature enough to be evaluated through a clinical trial that aims at evaluating its diagnostic accuracy for skin carcinoma diagnosis. Full article
(This article belongs to the Special Issue Advanced Laser Technologies for Biophotonics)
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14 pages, 3483 KiB  
Article
Lipofuscin-Type Pigment as a Marker of Colorectal Cancer
by Sónia Carvalho, Isa Carneiro, Rui Henrique, Valery Tuchin and Luís Oliveira
Electronics 2020, 9(11), 1805; https://doi.org/10.3390/electronics9111805 - 31 Oct 2020
Cited by 10 | Viewed by 2115
Abstract
The study of the optical properties of biological tissues for a wide spectral range is necessary for the development and planning of noninvasive optical methods to be used in clinical practice. In this study, we propose a new method to calculate almost all [...] Read more.
The study of the optical properties of biological tissues for a wide spectral range is necessary for the development and planning of noninvasive optical methods to be used in clinical practice. In this study, we propose a new method to calculate almost all optical properties of tissues as a function of wavelength directly from spectral measurements. Using this method, and with the exception of the reduced scattering coefficient, which was obtained by traditional simulation methods, all the other optical properties were calculated in a simple and fast manner for human and pathological colorectal tissues. The obtained results are in good agreement with previous published data, both in magnitude and in wavelength dependence. Since this method is based on spectral measurements and not on discrete-wavelength experimental data, the calculated optical properties contain spectral signatures that correspond to major tissue chromophores such as DNA and hemoglobin. Analysis of the absorption bands of hemoglobin in the wavelength dependence of the absorption spectra of normal and pathological colorectal mucosa allowed to identify differentiated accumulation of a pigment in these tissues. The increased content of this pigment in the pathological mucosa may be used for the future development of noninvasive diagnostic methods for colorectal cancer detection. Full article
(This article belongs to the Special Issue Advanced Laser Technologies for Biophotonics)
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13 pages, 1430 KiB  
Article
Photostimulation of Extravasation of Beta-Amyloid through the Model of Blood-Brain Barrier
by Ekaterina Zinchenko, Maria Klimova, Aysel Mamedova, Ilana Agranovich, Inna Blokhina, Tatiana Antonova, Andrey Terskov, Alexander Shirokov, Nikita Navolokin, Andrey Morgun, Elena Osipova, Elizaveta Boytsova, Tingting Yu, Dan Zhu, Juergen Kurths and Oxana Semyachkina-Glushkovskaya
Electronics 2020, 9(6), 1056; https://doi.org/10.3390/electronics9061056 - 26 Jun 2020
Cited by 14 | Viewed by 2831
Abstract
Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic [...] Read more.
Alzheimer’s disease (AD) is an incurable pathology associated with progressive decline in memory and cognition. Phototherapy might be a new promising and alternative strategy for the effective treatment of AD, and has been actively discussed over two decades. However, the mechanisms of therapeutic photostimulation (PS) effects on subjects with AD remain poorly understood. The goal of this study was to determine the mechanisms of therapeutic PS effects in beta-amyloid (Aβ)-injected mice. The neurological severity score and the new object recognition tests demonstrate that PS 9 J/cm2 attenuates the memory and neurological deficit in mice with AD. The immunohistochemical assay revealed a decrease in the level of Aβ in the brain and an increase of Aβ in the deep cervical lymph nodes obtained from mice with AD after PS. Using the in vitro model of the blood-brain barrier (BBB), we show a PS-mediated decrease in transendothelial resistance and in the expression of tight junction proteins as well an increase in the BBB permeability to Aβ. These findings suggest that a PS-mediated BBB opening and the activation of the lymphatic clearance of Aβ from the brain might be a crucial mechanism underlying therapeutic effects of PS in mice with AD. These pioneering data open new strategies in the development of non-pharmacological methods for therapy of AD and contribute to a better understanding of the PS effects on the central nervous system. Full article
(This article belongs to the Special Issue Advanced Laser Technologies for Biophotonics)
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