Special Issue "Advances in the Diagnosis and Prevention of Sudden Death"

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 557

Special Issue Editors

Special Issue Information

Dear Colleagues,

Sudden death is an event that occurs instantaneously, with no apparent symptoms or in any case within a very short time from the onset of symptoms, occurring completely unexpectedly for time and modality. Sudden deaths can affect people of any age, from infants to young adults to the elderly, with high mortality and impact on public health. The vast majority of cases of sudden death are attributable to events with cardiac etiology, such as fatal arrhythmias, acute myocardial infarction, cardiomyopathies, although acute fatal events with neurogenic or respiratory etiology are also possible. Diagnosing and preventing sudden deaths is certainly a major challenge, both for the clinician and for the pathologist. On the patient, clinical cases can be varied, with very different clinical presentations or often overlooked family histories for these events. On cadavers, on the other hand, the literature estimates that a significant proportion of sudden deaths, which can be estimated at around 1/3 of the cases, do not show diriment signs at post-mortem examination or show findings only suggestive of sudden death with no macroscopic or microscopic pathognomonic evidence. This invalidates the correct diagnosis of these events, making it difficult to identify them even in the post-mortem. The purpose of this Special Issue is to deepen research in the field of diagnostics and prevention of sudden deaths both in the patient and cadaver through the introduction of new research approaches aimed at reducing the impact of these events on public health . To this end, papers from all branches related to the topic of sudden deaths are welcome, including:

  • Forensic pathology;
  • Emergency Medicine;
  • Cardiology;
  • Anesthesiology;
  • Internal Medicine;
  • Neurology
  • Pneumology;
  • Genetics;
  • Molecular biology;
  • Clinical biochemistry;
  • Heart surgery;
  • Forensic Medicine;
  • Hygiene;
  • Gastroenterology;
  • Informatics.

Dr. Isabella Aquila
Dr. Matteo Antonio Sacco
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • diagnostics
  • sudden death
  • myocardial infarction
  • prevention
  • SIDS
  • clinical investigations

Published Papers (1 paper)

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12 pages, 270 KiB  
Unexplained and Unexpected Pediatric Deaths: Forensic Review and New Perspectives
Diagnostics 2023, 13(19), 3111; https://doi.org/10.3390/diagnostics13193111 - 02 Oct 2023
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Unexplained and unexpected pediatric deaths are a major challenge in global healthcare. The role of the forensic pathologist is crucial in determining the cause and manner of death in these cases, although to date, there are many limitations in post-mortem diagnosis. The role [...] Read more.
Unexplained and unexpected pediatric deaths are a major challenge in global healthcare. The role of the forensic pathologist is crucial in determining the cause and manner of death in these cases, although to date, there are many limitations in post-mortem diagnosis. The role of the autopsy and related forensic investigations become a fundamental tool to investigate and give an explanation for an unacceptable event, considering the young age of the victims. From this point of view, even today, it is necessary that this phenomenon is correctly recorded through standardized systems and universally accepted methods. Furthermore, it is essential that scientific research on this topic is increased through the implementation of universally accepted operating protocols recognizing real risk factors in order to prevent such events. The purpose of the study is to offer a review of the state of the art about unexplained pediatric death and, above all, to propose an international reporting platform, extending proper investigations not only to judicial cases but also to all the other cases of unexpected pediatric death. Full article
(This article belongs to the Special Issue Advances in the Diagnosis and Prevention of Sudden Death)
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