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Diagnostics
Special Issues
Updates in the Hysteroscopic Approach to Uterine Diseases: Molecular Bases,...
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Updates in the Hysteroscopic Approach to Uterine Diseases: Molecular Bases, Diagnostics and Therapeutics

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Medical Imaging and Theranostics".

Deadline for manuscript submissions: closed (30 April 2022) | Viewed by 4741

Special Issue Editors

Dr. Amerigo Vitagliano

E-Mail Website
Guest Editor
Unit of Obstetrics and Gynecology, Department of Biomedical and Human Oncological Science, University of Bari, 70100 Bari, Italy
Interests: reproductive medicine; assisted reproductive technology; infertility; embryology; immunology; reproductive surgery; artificial intelligence; fertility preservation; fertility counseling
Special Issues, Collections and Topics in MDPI journals
Dr. Marco Noventa

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Co-Guest Editor
Gynecologic and Obstetric Clinic, Department of Women and Children's Health, University of Padua, 35100 Padua, Italy
Interests: assisted reproductive technology; ovarian stimulation; fresh/frozen embryo transfer; endometrial preparation; endometrial receptivity; implantation; poor ovarian responders; endometriosis; transvaginal ultrasound; infertility surgery; laparoscopy; hysteroscopy Section: Medical Imaging
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Ettore Cicinelli

E-Mail Website
Co-Guest Editor
Ob/Gyn Institute, Department of Biomedical Sciences and Human Oncology, University of Bari "Aldo Moro", Bari, Italy
Interests: hysteroscopy; minimally-invasive surgery; oncology; endometritis; laparoscopy

Special Issue Information

Dear Colleagues, 

Hysteroscopy is the current gold standard for the diagnosis and treatment of intrauterine pathologies. It is the only technique available to gynecologists that offers direct visualization of the entire uterine cavity and provides the possibility of removing intrauterine lesions under direct visual control. Due to recent technological advancements (i.e., the introduction of miniaturized instruments and hysteroscopes), hysteroscopy has spread globally for the management of a plethora of pre-menopausal and post-menopausal conditions in the outpatient setting. Growing attention focused on endometrial factor infertility has also made hysteroscopy an indispensable technique for the management of infertility.

In this Special Issue, we would like to move this field forward by inviting original clinical and basic research articles, meta-analyses, and systematic reviews focusing on hysteroscopic diagnosis and management of uterine pathologies. Moreover, we welcome all articles focused on the molecular pathways underlying intrauterine diseases, including their potential influence on reproductive issues.

Dr. Amerigo Vitagliano
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Hysteroscopy
  • uterine pathologies
  • infertility
  • minimally invasive surgery
  • endometrial diseases
  • abnormal uterine bleeding
  • endometrial cancer.

Published Papers (2 papers)

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Research

9 pages, 862 KiB  
Article
Hysteroscopy as a Primary Tool in Exploration and Treatment of Infertility: Single Center Experience in Western Romania
by Cosmin Citu, Florin Gorun, Andrei Motoc, Ioan Sas, Oana Maria Gorun, Bogdan Burlea, Denis Mihai Serban, Radu Neamtu and Ioana Mihaela Citu
Diagnostics 2021, 11(10), 1917; https://doi.org/10.3390/diagnostics11101917 - 16 Oct 2021
Cited by 5 | Viewed by 2071
Abstract
(1) Background: Infertility is a disease that affects millions of individuals worldwide. Intrauterine lesions are common in infertile women, hysteroscopy being considered the gold standard for assessing them, even if in routine clinical practice indirect imaging techniques are the first-line investigative tools. The [...] Read more.
(1) Background: Infertility is a disease that affects millions of individuals worldwide. Intrauterine lesions are common in infertile women, hysteroscopy being considered the gold standard for assessing them, even if in routine clinical practice indirect imaging techniques are the first-line investigative tools. The aim of the study was to evaluate hysteroscopic findings among women with unexplained infertility and to analyze fertility outcomes after operative hysteroscopy; (2) Methods: a retrospective cohort study was conducted among 198 women with infertility that had undergone hysteroscopy as the first step of their infertility workup. (3) Results: The median age of the participants was 34 years, 67.7% of them being diagnosed with primary infertility. The most common abnormalities were endometrial polyps, uterine synechiae and uterine fibroids. In addition, pregnancy rates were 23.1% after hysteroscopic polypectomy, 11.1% after hysteroscopic myomectomy and 23.8% after uterine synechiae resection; (4) Conclusions: Endometrial polyps were the most common uterine abnormality found in women with infertility. Hysteroscopic interventions appeared to increase pregnancy rates and outcomes among these women. Full article
(This article belongs to the Special Issue Updates in the Hysteroscopic Approach to Uterine Diseases: Molecular Bases, Diagnostics and Therapeutics)
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11 pages, 254 KiB  
Article
Is Endometrial Scratching Beneficial for Patients Undergoing a Donor-Egg Cycle with or without Previous Implantation Failures? Results of a Post-Hoc Analysis of an RCT
by Alexandra Izquierdo, Laura de la Fuente, Katharina Spies, David Lora and Alberto Galindo
Diagnostics 2021, 11(7), 1167; https://doi.org/10.3390/diagnostics11071167 - 26 Jun 2021
Cited by 1 | Viewed by 1756
Abstract
Endometrial scratching (ES) has been proposed as a useful technique to improve outcomes in in vitro fertilization (IVF) cycles, particularly in patients with previous implantation failures. Our objective was to determine if patients undergoing egg-donor IVF cycles had better live birth rates after [...] Read more.
Endometrial scratching (ES) has been proposed as a useful technique to improve outcomes in in vitro fertilization (IVF) cycles, particularly in patients with previous implantation failures. Our objective was to determine if patients undergoing egg-donor IVF cycles had better live birth rates after ES, according to their previous implantation failures. Secondary outcomes were pregnancy rate, clinical pregnancy rate, ongoing pregnancy rate, miscarriage rate, and multiple pregnancy rate. We analysed the results of 352 patients included in the Endoscratch Trial (NCT03108157). A total of 209 were patients with one or no previous implantation failures (105 with an ES done in the previous cycle, group A1, and 104 without ES, group B1), and 143 were patients with at least two previous failed implantations (71 patients with ES, group A2, and 72 without ES, group B2). We found an improvement in pregnancy rates (62.9% in group A1 vs. 55.8% in group B1 vs. 70.4% in group A2 vs. 76.4% in group B2, p = 0.028) in patients with at least two previous implantation failures, but this difference was not statistically different when we compared clinical pregnancy rates (59.1% vs. 51.0% vs. 64.8% vs. 68.1% in groups A1, B1, A2 and B2, respectively, p = 0.104) and live birth rates (52.4% vs. 43.3% vs. 57.8% vs. 55.6% in groups A1, B1, A2 and B2, respectively, p = 0.218). According to these results, we conclude that there is no evidence to recommend ES in egg-donor IVF cycles, regardless of the number of previous failed cycles. Full article
(This article belongs to the Special Issue Updates in the Hysteroscopic Approach to Uterine Diseases: Molecular Bases, Diagnostics and Therapeutics)
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