State-of-the-Art Research on Epilepsy
A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".
Deadline for manuscript submissions: closed (30 June 2023) | Viewed by 5451
Special Issue Editors
Interests: behavior genetics; neurogenetics; physiological foundations of cognitive behavior; audiogenic epilepsy; epileptogenesis; neurogenesis of the adult brain
Special Issue Information
Dear Colleagues,
Epilepsy is a network disorder accompanied by severe metabolic violations. It affects approximately 1% of the worldwide population. The complexity of epileptogenesis requires intense interdisciplinary research using a variety of models, such as in silico, in vitro and in vivo. Recently, simple models of acute seizures, such as the maximal electroshock seizure test or the pentylenetetrazole seizure test, were used as the standard procedure for predicting clinical anticonvulsant activity for many drug candidates. Next, the kindling models and genetic models were developed, and they helped to overcome serious problems such as false-positive and false-negative evaluations of drug candidates.
In the majority of patients, seizures can be well-controlled when provided with adequately selected therapy. Nevertheless, current medications still fail to eradicate seizures in 30-40% of patients (so called pharmacoresistant epilepsy). Uncontrollable seizure episodes have a significant negative impact on patients’ quality of life, interfering with memory, cognition, comorbid depressive states and anxious disorders. This mediates the necessity of novel approaches and the analysis of seizure states in various models.
We encourage the submission of original research, case reports and review articles on behavioral, electrophysiological, molecular, bioinformatic and cellular pathology, involved in epileptogenesis.
Prof. Dr. Inga Poletaeva
Dr. Natalia Surina
Guest Editors
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- epilepsy
- animal models
- epileptogenesis
- reflex seizures
- genetics
- comorbid disorders
- kindling
- secondary epileptogenesis
- antiepileptic drugs
- therapy response prediction
- EEG
