Pathogenesis, Diagnosis, and Medical Management of Blood Clots

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: closed (15 April 2023) | Viewed by 1112

Special Issue Editor


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Guest Editor
1. Global Health Neurology Lab, Sydney, NSW 2000, Australia
2. Department of Neurology & Neurophysiology, Liverpool Hospital & South West Sydney Local Health District (SWSLHD), Liverpool, NSW 2170, Australia
Interests: neurology; biomarkers; clinical trials; cardiovascular diseases; stroke; telemedicine; COVID-19; neuropathology; neuroimmunology; neurodegenerative diseases; neurophysiology; clinical medicine; clinical neuroscience; public health
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Special Issue Information

Dear Colleagues,

Blood clots are a public health concern associated with significant morbidity and mortality. Blood clots in arteries, or arterial thrombosis, can manifest as ischemic stroke or ischemic heart disease. Similarly, blood clots in veins, or venous thrombosis, can present as venous thromboembolism (VTE), including pulmonary embolism (PE) and deep vein thrombosis (DVT). These conditions pose an ongoing challenge, especially in select group of patients, where aetiology cannot be determined despite extensive diagnostic work-up. This Special Issue will present a comprehensive overview of the latest advances in research into pathogenesis of blood clots as well as the diagnostics, prevention, and acute management of blood clots in clinical practice. More recently, studies suggested an increased risk of blood clots in patients with COVID-19, especially in hospitalized patients and those with moderate and severe illness. However, much remains to be delineated on the underlying mechanisms. Beyond our existing knowledge, gaps in the scientific understanding of pathogeneses, emerging avenues of future research, prevention and clinical practice variations, or improvement will also be discussed.

We invite submissions on a broad range of topics, including but not limited to cross-sectional studies, clinical trials, position paper/recommendations, hypothesis/perspective, systematic and narrative/comprehensive review. The articles in this section may be included in a forthcoming book to be published by MDPI.

Dr. Sonu M. M. Bhaskar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • blood clots
  • stroke
  • ischemic heart disease
  • myocardial infarction
  • venous thromboembolism
  • deep vein thrombosis
  • pulmonary embolism

Published Papers (1 paper)

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Research

14 pages, 1931 KiB  
Article
Comparing CT and MR Properties of Artificial Thrombi According to Their Composition
by Rebeka Viltužnik, Aleš Kaučič, Aleš Blinc, Jernej Vidmar and Igor Serša
Diagnostics 2023, 13(10), 1802; https://doi.org/10.3390/diagnostics13101802 - 19 May 2023
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Abstract
This study aims to determine whether and to what extent the structure and composition of thrombi can be assessed using NMR and CT measurements. Seven different thrombus models, namely, six RBC thrombi with hematocrit levels (HTs) of 0%, 20%, 40%, 60%, 80% and [...] Read more.
This study aims to determine whether and to what extent the structure and composition of thrombi can be assessed using NMR and CT measurements. Seven different thrombus models, namely, six RBC thrombi with hematocrit levels (HTs) of 0%, 20%, 40%, 60%, 80% and 100% and one platelet thrombus model, were analyzed using proton NMR at 100 MHz and 400 MHz, with measurements of T1 and T2 NMR relaxation times and measurements of the apparent diffusion coefficient (ADC). In addition, the thrombus models were CT-scanned in a dual-energy mode (80 kV and 140 kV) and in a single-energy mode (80 kV) to measure their CT numbers. The results confirmed that RBC thrombi can be distinguished from platelet thrombi by using ADC and CT number measurements in all three settings, while they cannot be distinguished by using T1 and T2 measurements. All measured parameters allowed for the differentiation of RBC thrombi according to their HT values, but the best sensitivity to HT was obtained with ADC and single-energy CT measurements. The importance of this study also lies in the potential application of its results for the characterization of actual thrombi in vivo. Full article
(This article belongs to the Special Issue Pathogenesis, Diagnosis, and Medical Management of Blood Clots)
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