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Diagnostics
Special Issues
Diagnosis and Management of Reproductive Disorders
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Diagnosis and Management of Reproductive Disorders

A special issue of Diagnostics (ISSN 2075-4418). This special issue belongs to the section "Pathology and Molecular Diagnostics".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 1871

Special Issue Editors

Dr. Bogdan Doroftei

E-Mail Website
Guest Editor
Mother and Child Medicine Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: human reproduction preimplantational genetic testing and rare disease endometriosis minimal invasive surgery
Special Issues, Collections and Topics in MDPI journals
Dr. Radu Maftei

E-Mail Website
Guest Editor
Mother and Child Medicine Department, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania
Interests: in vitro fertilization; obstetric and gynecological ultrasound; assisted reproductive technology; reproductive medicine; semen analysis; embryos; oocytes and retrieval; embryology
Dr. Ovidiu Dumitru Ilie

E-Mail Website
Guest Editor
Origyn Fertility Center, 3C Palace Street, 700032 Iasi, Romania
Interests: reproductive tract microbiota; reproductive biology; genetic abnormalities; fertility manipulation; biotechnology; experimental models

Special Issue Information

Dear Colleagues,

We are setting the grounds for a Special Issue entitled “Diagnosis and Management of Reproductive Disorders” as part of the journal Diagnostics. Thus, it is our great pleasure to invite you to submit a manuscript through which the field of reproductive medicine can be expanded and brought one step closer to improving patients’ quality of life, pregnancy success rates, and management strategies.

Considering that reproductive health is the quintessence not only of modern society but also of future generations, it is imperative to preserve its biology since various endo- and exogenous factors have been documented to exert, individually or in a collaborative manner, detrimental effects with long-lasting consequences that lead to impairment. This may subsequently reflect a high predisposition to distinct conditions that range from infections and sexual dysfunction to congenital abnormalities and cancer.

Therefore, recent advances in biotechnology and molecular biology may aid us in comprehending the overall nature of reproductive disorders by paving the way for novel research, clinical opportunities, and perspectives. Conclusively, this Special Issue intends to gather research articles performed on human patients or experimental models and literature synthesis papers.

Dr. Bogdan Doroftei
Dr. Radu Maftei
Dr. Ovidiu Dumitru Ilie
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diagnostics is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • family planning
  • sex differences
  • psychological distress
  • reproductive disorders
  • in vitro fertilization
  • next generation sequencing
  • assisted reproductive technology
  • fertility status
  • reproduction
  • minimally and non-invasive diagnosis
  • infertility
  • fertility preservation
  • innovative therapies

Published Papers (2 papers)

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Research

13 pages, 2462 KiB  
Article
Overexpression of Connexin 40 in the Vascular Endothelial Cells of Placenta with Acute Chorioamnionitis
by Jia Yee Tan, Hannah Xin Yi Yeoh, Wai Kit Chia, Jonathan Wei De Tan, Azimatun Noor Aizuddin, Wirda Indah Farouk, Nurwardah Alfian, Yin Ping Wong and Geok Chin Tan
Diagnostics 2024, 14(8), 811; https://doi.org/10.3390/diagnostics14080811 - 12 Apr 2024
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Abstract
Background: Connexins (Cx) 43 and 40 play a role in leukocytes recruitment in acute inflammation. They are expressed in the endothelial cells. They are also found in the placenta and involved in the placenta development. Acute chorioamnionitis is associated with an increased risk [...] Read more.
Background: Connexins (Cx) 43 and 40 play a role in leukocytes recruitment in acute inflammation. They are expressed in the endothelial cells. They are also found in the placenta and involved in the placenta development. Acute chorioamnionitis is associated with an increased risk of adverse perinatal outcomes. The aim of this study was to determine the expressions of Cx43 and Cx40 in the placenta of mothers with acute chorioamnionitis, and to correlate their association with the severity of chorioamnionitis and adverse perinatal outcomes. Methods: This study comprised a total of 81 cases, consisting of 39 placenta samples of mothers with acute chorioamnionitis and 42 non-acute chorioamnionitis controls. Cx43 and Cx40 immunohistochemistry were performed on all cases and their expressions were evaluated on cytotrophoblasts, syncytiotrophoblasts, chorionic villi endothelial cells, stem villi endothelial cells, maternal endothelial cells and decidua of the placenta. Results: Primigravida has a significantly higher risk of developing acute chorioamnionitis (p < 0.001). Neonates of mothers with a higher stage of fetal inflammatory response was significantly associated with lung complications (p = 0.041) compared to neonates of mothers with a lower stage. The expression of Cx40 was significantly higher in fetal and maternal vascular endothelial cells in acute chorioamnionitis (p < 0.001 and p = 0.037, respectively) compared to controls. Notably, Cx43 was not expressed in most of the types of cells in the placenta, except for decidua. Both Cx43 and Cx40 expressions did not have correlation with the severity of acute chorioamnionitis and adverse perinatal outcomes. Conclusion: Cx40 was overexpressed in the fetal and maternal vascular endothelial cells in the placenta of mothers with acute chorioamnionitis, and it may have a role in the development of inflammation in placenta. Full article
(This article belongs to the Special Issue Diagnosis and Management of Reproductive Disorders)
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12 pages, 2606 KiB  
Article
Killer Cell Immunoglobulin-like Receptor Genotypes and Reproductive Outcomes in a Group of Infertile Women: A Romanian Study
by Mihai Surcel, Iulia Adina Neamtiu, Daniel Muresan, Iulian Goidescu, Adelina Staicu, Monica Mihaela Marta, Georgiana Nemeti, Radu Harsa, Bogdan Doroftei, Mihai Emil Capilna and Gabriela Caracostea
Diagnostics 2023, 13(19), 3048; https://doi.org/10.3390/diagnostics13193048 - 25 Sep 2023
Viewed by 997
Abstract
A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes [...] Read more.
A growing body of evidence suggests that endometrial immune disorders may be responsible for endometrial dysfunctions that can lead to gynecological and obstetrical pathology. The aim of this study was to explore the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes. We conducted a prospective cohort study that included 104 infertile patients undergoing an in vitro fertilization procedure. All participants underwent clinical and ultrasound examination, genetic evaluation (KIR genotyping), endometrial washing fluid sampling for cytokine determination, endometrial tissue sampling for histologic assessment and hysteroscopic evaluation. Our analysis showed statistically significant lower levels of uterine cytokines TNF-α (p = 0.001) and IL-1beta (p = 0.000) in the KIR AA genotype group as compared to KIR AB and BB among study participants with chronic endometritis. The study results suggest that the KIR AA genotype population subgroups may be more susceptible to developing endometrial disorders such as chronic endometritis. The changes in the behavior of NK cells seem to be subtle and expressed as an altered regulatory pattern. Full article
(This article belongs to the Special Issue Diagnosis and Management of Reproductive Disorders)
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