Therapeutic Strategies for Diabetic Kidney Disease

A special issue of Diabetology (ISSN 2673-4540).

Deadline for manuscript submissions: closed (25 May 2022) | Viewed by 5655

Special Issue Editors


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Guest Editor
Division of Diabetes, Endocrinology, and Metabolism, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8, Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan
Interests: diabetes; diabetic kidney disease; diabetic nephropathy; obesity; Rho-kinase; ROCK
Hospitalist in Tennova Health Center, Cleveland, TN, USA
Interests: kidney disease; Nonalcoholic Fatty Liver Disease; cirrhosis

Special Issue Information

Dear colleagues,

Diabetic kidney disease (DKD) is a worldwide public health concern. It is the leading cause of end-stage renal disease (ESRD) and is strongly associated with high cardiovascular death rate in patients with diabetes. The pathological significance of activated renin-angiotensin system (RAS) and hemodynamic changes is becoming increasingly evident, and a large number of diabetic patients are treated with RAS and/or SGLT2 inhibitors. While currently approved, these agents can retard but not completely prevent the progression to ESRD and cardiovascular events. Given the importance of DKD as a major risk factor for macrovascular complications, it is important to understand how this disease progresses and how the vascular disease is involved.

In this Special Issue of Diabetology, we invite researchers to submit original research articles as well as review articles focusing on the molecular mechanisms of DKD. Contributions demonstrating original therapeutic opportunities or strategies for reducing cardiovascular complications are also encouraged.

Dr. Keiichiro Matoba
Dr. Naga Samji
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Diabetology is an international peer-reviewed open access quarterly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diabetic kidney disease
  • diabetes
  • obesity
  • insulin resistance
  • endothelial dysfunction
  • atherosclerosis
  • reno-cardiac syndrome
  • renin-angiotensin system
  • inflammation
  • oxidative stress
  • signaling cascade
  • mitochondrial homeostasis
  • therapeutic approaches

Published Papers (1 paper)

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Review

14 pages, 318 KiB  
Review
First, Do No Harm: Critical Appraisal of Protein Restriction for Diabetic Kidney Disease
by Satoru Yamada
Diabetology 2021, 2(2), 51-64; https://doi.org/10.3390/diabetology2020005 - 22 Apr 2021
Cited by 2 | Viewed by 4300
Abstract
Low-protein diets have been recommended as diet therapy for the management of chronic kidney disease; however, its effect on chronic kidney disease has not been scientifically proven. Although several studies have reported significantly more favorable results with low-protein diet than with normal-protein diet, [...] Read more.
Low-protein diets have been recommended as diet therapy for the management of chronic kidney disease; however, its effect on chronic kidney disease has not been scientifically proven. Although several studies have reported significantly more favorable results with low-protein diet than with normal-protein diet, the renal protective effects of low-protein diets are still unclear in diabetic patients with chronic kidney disease. Moreover, some studies have reported that extremely low-protein diets may increase the risk of mortality. Thus, this paper describes the effectiveness and safety of low-protein diets for patients with diabetic kidney disease by reviewing the historical background of different low-protein diets that were critically examined in several studies. Full article
(This article belongs to the Special Issue Therapeutic Strategies for Diabetic Kidney Disease)
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