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Dentistry Journal
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Molecular Diagnostics in Oral Diseases: Volume II
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Molecular Diagnostics in Oral Diseases: Volume II

A special issue of Dentistry Journal (ISSN 2304-6767). This special issue belongs to the section "Oral Hygiene, Periodontology and Peri-implant Diseases".

Deadline for manuscript submissions: 5 August 2024 | Viewed by 5953

Special Issue Editors

Prof. Dr. Marinka Mravak-Stipetić

E-Mail Website
Guest Editor
Faculty of Dental Medicine and Health, University Josip Juraj Strossmayer Osijek, HR-31000 Osijek, Croatia
Interests: molecular diagnostics of oral diseases; oral diagnostics; oral infections; oral-systemic health connection; multidisciplinary approach to oral diseases; applications of pharmacogenomics in oral diseases; pharmacogenetic testing in oral adverse drug reactions
Special Issues, Collections and Topics in MDPI journals
Dr. Ivan Salarić

E-Mail Website
Guest Editor
Department of Oral Surgery, School of Dental Medicine, University of Zagreb, Gundulićeva 5, 10000 Zagreb, Croatia
Interests: salivary diagnostics; salivary biomarkers; oral cancer; molecular diagnostics of oral diseases; dental implantology; oral and maxillofacial pathology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

It is a privilege to invite you to submit your paper and present your research in the upcoming Special Issue “Molecular Diagnostics in Oral Diseases: Volume II”, which will be considered for publication in the Dentistry Journal.

Molecular diagnostics has revolutionized diagnostics through research, diagnosis, and treatment of many diseases at the molecular level of DNA, RNA, or proteins, contributing to the molecular characterization of various diseases. Understanding the molecular pathogenesis of oral diseases based on the application of molecular diagnostics techniques with a goal to expedite diagnosis, prognosis, prevention, and monitoring of disease or creation of patient-based therapy presents a particular challenge in dental medicine. 

This Special Issue addresses a wide range of oral diseases and their molecular characterization based on the analysis of oral tissues and oral fluids using standard molecular genetics and -omics technologies. Furthermore, it addresses all research that investigates the potential connection and interactions between systemic and oral diseases.

The purpose of this issue is to create a platform to present new information and expand current knowledge about the molecular basis of oral diseases to pinpoint early variations and diagnosis, predict the course, and enable personalized treatment by developing, applying, and monitoring the impact of new drugs in the treatment and prevention of oral diseases.

To contribute to this rapidly developing field of oral disease diagnostics, please refer to the keywords below to submit your research for this Special Issue.

Prof. Dr. Marinka Mravak-Stipetić
Dr. Ivan Salarić
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Dentistry Journal is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2000 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular diagnostics of oral diseases
  • molecular techniques
  • oral microbiome
  • salivary microbiome
  • salivary metabolome
  • oral infections
  • oral and maxillofacial pathology
  • oral cancer
  • oral health in the era of personalized medicine
  • salivary biomarkers
  • genomic dentistry
  • oral chronic cGVHD
  • pharmacogenomics
  • systemic manifestations of oral diseases
  • oral manifestations of systemic diseases

Published Papers (4 papers)

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Research

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14 pages, 4449 KiB  
Article
Regeneration of Buccal Wall Defects after Tooth Extraction with Biphasic Calcium Phosphate in Injectable Form vs. Bovine Xenograft: A Randomized Controlled Clinical Trial
by Marija Čandrlić, Matej Tomas, Marko Matijević, Željka Perić Kačarević, Marijana Bićanić, Žarko Udiljak, Ivana Butorac Prpić, Ivan Miškulin, Slavko Čandrlić and Aleksandar Včev
Dent. J. 2023, 11(9), 223; https://doi.org/10.3390/dj11090223 - 19 Sep 2023
Viewed by 1705
Abstract
Bone healing after tooth extraction may be affected by defects of the alveolus buccal wall, such as fenestrations and dehiscences. Therefore, to minimize dimensional changes it is advisable to perform alveolar ridge preservation after tooth extractions. Different biomaterials are used for this purpose. [...] Read more.
Bone healing after tooth extraction may be affected by defects of the alveolus buccal wall, such as fenestrations and dehiscences. Therefore, to minimize dimensional changes it is advisable to perform alveolar ridge preservation after tooth extractions. Different biomaterials are used for this purpose. The aim of this study was to investigate the qualitative and quantitative histological changes in human biopsies taken after 6 months of healing of extraction sockets with buccal wall defects. For this purpose, the defects of 36 patients (18 per group) were treated with injectable biphasic calcium phosphate (I-BCP) or bovine xenograft (BX) after extraction. After six months of healing, biopsies were taken and proceeded to the histology laboratory. No evidence of an inflammatory response of the tissue was observed in the biopsies of either group, and the newly formed bone (NB) was in close contact with the remaining biomaterial (BM). The histomorphometric results showed that there was no statistically significant difference between the groups in the mean percentage of NB (p = 0.854), BM (p = 0.129), and soft tissue (p = 0.094). To conclude, both biomaterials exhibited osteoconductivity and biocompatibility and achieved satisfactory bone regeneration of buccal wall defects after tooth extraction. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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12 pages, 2573 KiB  
Article
Wnt Signaling Activation in Gingival Epithelial Cells and Macrophages of Experimental Periodontitis
by Ying Chen and Yang Hu
Dent. J. 2023, 11(5), 129; https://doi.org/10.3390/dj11050129 - 09 May 2023
Viewed by 1343
Abstract
Objective: Wingless/integrated (Wnt) signaling plays critical roles in maintaining environmental homeostasis and is also involved in the pathogenesis of inflammatory diseases. However, its role in macrophages during periodontitis is not well understood. The present study aims to investigate the interaction between Wnt [...] Read more.
Objective: Wingless/integrated (Wnt) signaling plays critical roles in maintaining environmental homeostasis and is also involved in the pathogenesis of inflammatory diseases. However, its role in macrophages during periodontitis is not well understood. The present study aims to investigate the interaction between Wnt signaling and macrophages in the context of periodontitis. Methods: Experimental periodontitis was induced in C57/BL6 mice using a Porphyromonas gingivalis (P.g)-associated ligature for 14 days. Immunohistochemistry was performed to study the expression of the pro-inflammatory cytokine tumor necrosis factor (TNF-α), the stabilization of β-catenin, and the macrophage marker F4/80 in the periodontal tissues. The effect of Wnt signaling on TNF-α was examined using Western blot analysis in Raw 264.7 murine macrophages stimulated by Wnt3a-conditioned medium, with or without Wnt3a antibody neutralization, and compared with primary cultured gingival epithelial cells (GECs). The effect of P.g lipopolysaccharide (LPS) on Wnt signaling was assessed by analyzing key components of the Wnt signaling pathway, including the activity of low-density lipoprotein receptor-related protein (LRP) 6 and nuclear accumulation of β-catenin in GEC and Raw 264.7 cells. Results: Over-expressions of TNF-α and activated β-catenin were presented in the macrophages in the gingiva from mice with P.g-associated ligature-induced periodontitis. The expression patterns of TNF-α and activated β-catenin were consistent with the expression of F4/80. In Raw 264.7 cells, activation of the Wnt signaling pathway led to an increase in TNF-α, but this effect was not observed in GEC. Additionally, treatment with LPS induced β-catenin accumulation and LRP6 activation in Raw 264.7 cells, which were blocked by the addition of Dickkopf-1(DKK1). Conclusions: Wnt signaling was aberrantly activated in the macrophages in experimental periodontitis. The activation of Wnt signaling in the macrophages may play a pro-inflammatory role in periodontitis. Targeting specific signaling pathways, such as the Wnt pathway, may hold promise for developing novel therapeutic interventions for periodontitis. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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14 pages, 2072 KiB  
Article
Retrospective Longitudinal Study on Changes in Atmospheric Pressure as a Predisposing Factor for Odontogenic Abscess Formation
by Marko Tarle, Arijan Zubović, Boris Kos, Marina Raguž and Ivica Lukšić
Dent. J. 2023, 11(2), 42; https://doi.org/10.3390/dj11020042 - 08 Feb 2023
Cited by 1 | Viewed by 1645
Abstract
In our retrospective longitudinal study based on the data from 292 patients, we wanted to investigate whether there was an association between weather conditions and the occurrence of odontogenic abscesses (OA) requiring hospitalization. In the adult group (249 patients), the incidence of severe [...] Read more.
In our retrospective longitudinal study based on the data from 292 patients, we wanted to investigate whether there was an association between weather conditions and the occurrence of odontogenic abscesses (OA) requiring hospitalization. In the adult group (249 patients), the incidence of severe OA was highest in winter (32.9%) during January (11.6%), with the most common localizations being the perimandibular (35.7%) and submandibular (23.3%) regions. We found that changes in mean daily atmospheric pressure five days before hospitalization showed a positive association with the occurrence of OA, especially pressure variations greater than 12 hPa. Atmospheric pressure changes two and five days before hospitalization were also found to be moderate predictors of complications during treatment. Antibiogram analysis revealed resistance of streptococci to clindamycin in 26.3%. In the pediatric group, OA were also most frequent in winter (30.2%), and the perimandibular region (37.2%) and the canine fossa (20.9%) were the most frequent abscess localizations, while an association with meteorological parameters was not demonstrated. Clinical experience teaches us that weather change influences the occurrence of severe OA requiring hospitalization, which we confirmed in this research. To our knowledge, our study is the first to provide a threshold and precise time frame for atmospheric pressure changes. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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Review

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20 pages, 3499 KiB  
Review
The Impact of Vitamin Deficiencies on Oral Manifestations in Children
by Stjepanka Lešić, Zrinka Ivanišević, Bruno Špiljak, Matej Tomas, Magdalena Šoštarić and Aleksandar Včev
Dent. J. 2024, 12(4), 109; https://doi.org/10.3390/dj12040109 - 17 Apr 2024
Viewed by 524
Abstract
Vitamins play a vital role in human health, particularly in the development and maintenance of oral health in children. These nutrients are broadly categorized into fat-soluble and water-soluble types, crucial for children’s well-being. The objective of this study is to investigate the impact [...] Read more.
Vitamins play a vital role in human health, particularly in the development and maintenance of oral health in children. These nutrients are broadly categorized into fat-soluble and water-soluble types, crucial for children’s well-being. The objective of this study is to investigate the impact of vitamin deficiencies on the oral health of children, focusing on how these deficiencies contribute to various oral health issues and determining the relationship between specific vitamin shortages and oral diseases. Findings indicate that shortages in vitamins A and D lead to enamel issues and a higher susceptibility to dental diseases, vitamin E assists in treating oral mucositis, and vitamin K is essential for blood clotting in dental surgeries. Deficits in B-complex and vitamin C result in enamel hypomineralization and soft tissue ailments, including aphthous stomatitis and gingival petechiae. Additionally, a lack of vitamin B7 compromises the immune response, increasing oral candidiasis risk. Therefore, vitamin deficiencies markedly affect children’s oral health, highlighting the need for joint efforts between dental professionals and caregivers for effective pediatric care. Addressing vitamin deficiencies through supplementation and tailored dental care emphasizes the significance of nutritional health in children’s overall and dental well-being, advocating for a collaborative approach to achieve optimal health outcomes. Full article
(This article belongs to the Special Issue Molecular Diagnostics in Oral Diseases: Volume II)
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