Liver Transplantation for Cancer: The Future of Transplant Oncology

A special issue of Current Oncology (ISSN 1718-7729).

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1357

Special Issue Editor


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Guest Editor
Department of Surgery and Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1, Maidashi, Higashi-ku, Fukuoka City 812-8582, Fukuoka, Japan
Interests: liver; transplantation; hepatocellular carcinoma; cholangiocellular carcinoma; surgery
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Special Issue Information

Dear Colleagues,

Liver transplantation (LT) for hepatocellular carcinoma (HCC) is a treatment that includes the underlying cirrhosis; theoretically, there is no better treatment. Many studies showed that selected patients with HCC can have improved outcomes after LT. Recently, other hepatobiliary malignancies, such as unresectable perihilar cholangiocarcinoma or liver metastasis for colorectal cancer, have been treated by LT with significant improved outcomes. The concept of such cancer treatment is defined as “transplant oncology”. On the other hand, there are some cautious views that LT for non-HCC malignancies including neuroendocrine tumors should be performed only in high-volume centers under strict selection criteria due to the current shortage of available organs. With this Special Issue, we aim to discuss the selection criteria, pre-LT treatment, appropriate immunosuppressive regimen, and strategies for the follow-up of LT for hepatobiliary malignancies to establish the concept of transplant oncology. 

You may choose our Joint Special Issue in Cancers.

Prof. Dr. Tomoharu Yoshizumi
Guest Editor

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Published Papers (1 paper)

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12 pages, 402 KiB  
Review
Liver Transplantation for Unresectable Colorectal Liver Metastasis: Perspective and Review of Current Literature
by Todd J. Robinson, Kaelyn Cummins and Allan Tsung
Curr. Oncol. 2024, 31(2), 1079-1090; https://doi.org/10.3390/curroncol31020080 - 16 Feb 2024
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Abstract
The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a major operation with the associated requirement for postoperative immunosuppression. [...] Read more.
The treatment of unresectable colorectal liver metastasis (CRLM) has previously been limited to palliative chemotherapy. Traditionally, the role of liver transplant has not been associated with sufficient survival to justify a patient undergoing a major operation with the associated requirement for postoperative immunosuppression. With improvements in chemotherapy options, a certain subset of patients can experience stable disease for years, which has prompted investigation into the role of liver transplant in these patients. Several recent studies have shown promising results in well-selected patients, with posttransplant survival approaching that of liver transplant recipients for other diseases. Here, we present a review of the data and current protocols for liver transplant for unresectable CRLM. Full article
(This article belongs to the Special Issue Liver Transplantation for Cancer: The Future of Transplant Oncology)
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