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Current Oncology
Special Issues
Long-Term Complications Following Radiation Therapy for Head and Neck Cancer
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Long-Term Complications Following Radiation Therapy for Head and Neck Cancer

A special issue of Current Oncology (ISSN 1718-7729). This special issue belongs to the section "Head and Neck Oncology".

Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 11334

Special Issue Editor

Dr. Sarah Hamilton

E-Mail Website
Guest Editor
British Columbia Cancer Agency (BCCA) – Vancouver Centre, Vancouver, BC V5Z 1M9, Canada
Interests: head and neck cancer; radiotherapy; survivorship; treatment toxicity; patient-reported outcomes

Special Issue Information

Dear Colleagues,

Radiotherapy plays an important role in the treatment of head and neck cancer in the curative, adjuvant and palliative settings. However, radiotherapy is associated with significant acute and long-term complications, including chronic xerostomia, dysphagia, neck fibrosis, and dental decay. Additional long-term side effects may include hypothyroidism, carotid artery stenosis and second malignancy. As survival rates of head and neck cancer are improving, the impact of radiation therapy in the long term becomes of utmost importance. This Special Issue aims to explore the short- and long-term toxicities of head and neck radiotherapy and the impact of toxicities on patient-reported outcomes and quality of life.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: acute complications from head and neck radiotherapy, long-term side effects from head and neck cancer radiotherapy, head and neck cancer survivorship and quality of life, and patient-reported outcomes for head and neck cancer.

I am looking forward to receiving your contributions.

Dr. Sarah Hamilton
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Oncology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • head and neck cancer
  • radiotherapy
  • later side effects
  • treatment toxicity
  • patient-reported outcomes
  • oral complications
  • xerostomia
  • radiation-associated dysphagia

Published Papers (3 papers)

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Review

23 pages, 5953 KiB  
Review
Radiotherapy in Uveal Melanoma: A Review of Ocular Complications
by Lamprini Banou, Zoi Tsani, Konstantinos Arvanitogiannis, Maria Pavlaki, Anna Dastiridou and Sofia Androudi
Curr. Oncol. 2023, 30(7), 6374-6396; https://doi.org/10.3390/curroncol30070470 - 3 Jul 2023
Cited by 4 | Viewed by 2285
Abstract
Uveal melanoma represents the most prevalent form of primary malignant intraocular tumor in adults. Historically, enucleation was considered the gold-standard approach in the treatment of uveal melanoma. Currently, radiotherapy is the most commonly used therapy, aiming at a better quality of life. However, [...] Read more.
Uveal melanoma represents the most prevalent form of primary malignant intraocular tumor in adults. Historically, enucleation was considered the gold-standard approach in the treatment of uveal melanoma. Currently, radiotherapy is the most commonly used therapy, aiming at a better quality of life. However, radiotherapy can result in several ocular complications, some of which may be vision-threatening. Radiation-induced dry eye, scleral necrosis, cataract, rubeosis iridis, neovascular glaucoma, radiation retinopathy, maculopathy, and optic neuropathy are the most common complications. This article aims to summarize the current literature regarding the ocular complications after radiotherapy, as well as their clinical features, risk factors, and management strategies. A thorough understanding of these issues is crucial for ophthalmologists and oncologists to provide optimal patient care, improve visual outcomes, and minimize long-term complications. Full article
(This article belongs to the Special Issue Long-Term Complications Following Radiation Therapy for Head and Neck Cancer)
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15 pages, 334 KiB  
Review
Xerostomia: From Pharmacological Treatments to Traditional Medicine—An Overview on the Possible Clinical Management and Prevention Using Systemic Approaches
by Luigi Sardellitti, Antonella Bortone, Enrica Filigheddu, Francesca Serralutzu and Egle Patrizia Milia
Curr. Oncol. 2023, 30(5), 4412-4426; https://doi.org/10.3390/curroncol30050336 - 24 Apr 2023
Viewed by 3635
Abstract
Despite high incidence rates and severe complications, the management of xerostomia lacks clinical guidelines. The aim of this overview was to summarize the clinical experience derived from the last 10 years of treatments and prevention using systemic compounds. Results showed that the cytoprotective [...] Read more.
Despite high incidence rates and severe complications, the management of xerostomia lacks clinical guidelines. The aim of this overview was to summarize the clinical experience derived from the last 10 years of treatments and prevention using systemic compounds. Results showed that the cytoprotective drug amifostine, and its antioxidant agents, are the most discussed as preventive agents of xerostomia in head and neck cancer (HNC) patients. In the presence of the disease, the pharmacological treatments have been mainly directed to stimulate secretion of the damaged salivary glands, or to counteract a decreased capacity of the antioxidant system, in view of an increasing of reactive oxygen species (ROS). However, the data demonstrated low ability of the drugs, together with a great number of side effects, which strongly limit their use. Concerning traditional medicine (TM), valid clinical trials are so limited that neither the efficacy nor the absence of interferences to concomitant chemical therapies can be validated. Consequently, the management of xerostomia and its devastating complications remain a very significant void in daily clinical practice. Full article
(This article belongs to the Special Issue Long-Term Complications Following Radiation Therapy for Head and Neck Cancer)
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Graphical abstract

14 pages, 331 KiB  
Review
Interventions for the Prevention of Oral Mucositis in Patients Receiving Cancer Treatment: Evidence from Randomised Controlled Trials
by Giuseppe Colella, Ciro Emiliano Boschetti, Rita Vitagliano, Chiara Colella, Lebei Jiao, Natalie King-Smith, Chong Li, Yii Nuoh Lau, Zacchaeus Lai, Ali Ibrahim Mohammed and Nicola Cirillo
Curr. Oncol. 2023, 30(1), 967-980; https://doi.org/10.3390/curroncol30010074 - 10 Jan 2023
Cited by 8 | Viewed by 4749
Abstract
Oral mucositis is a common and most debilitating complication associated with cancer therapy. Despite the significant clinical and economic impact of this condition, there is little to offer to patients with oral mucositis, and the medications used in its management are generally only [...] Read more.
Oral mucositis is a common and most debilitating complication associated with cancer therapy. Despite the significant clinical and economic impact of this condition, there is little to offer to patients with oral mucositis, and the medications used in its management are generally only palliative. Given that mucositis is ultimately a predictable and, therefore, potentially preventable condition, in this study we appraised the scientific literature to evaluate effective methods of prevention that have been tested in randomised controlled trials (RCTs). Published high-level evidence shows that multiple preventative methods are potentially effective in the prevention of oral mucositis induced by radiotherapy, chemotherapy, or both. Anti-inflammatory medications (including benzydamine), growth factors and cytokines (including palifermin), cryotherapy, laser-and-light therapy, herbal medicines and supplements, and mucoprotective agents (including oral pilocarpine) showed some degree of efficacy in preventing/reducing the severity of mucositis with most anticancer treatments. Allopurinol was potentially effective in the prevention of radiotherapy-induced oral mucositis; antimicrobial mouthwash and erythropoietin mouthwash were associated with a lower risk of development of severe oral mucositis induced by chemotherapy. The results of our review may assist in highlighting the efficacy and testing the effectiveness of low-cost, safe preventative measures for oral mucositis in cancer patients. Full article
(This article belongs to the Special Issue Long-Term Complications Following Radiation Therapy for Head and Neck Cancer)
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