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Protein Hydrolysates: Biological Activity and Applications
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Protein Hydrolysates: Biological Activity and Applications

A special issue of Current Issues in Molecular Biology (ISSN 1467-3045). This special issue belongs to the section "Biochemistry, Molecular and Cellular Biology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 2984

Special Issue Editor

Dr. Michele M. Iskandar

E-Mail Website
Guest Editor
School of Human Nutrition, McGill University, Montreal, QC H9X 3V9, Canada
Interests: bioactive food compounds; protein hydrolysates; peptides; human digestion; gut microbiome; phytochemicals
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Proteins are a type of important biological macromolecules involved in physiological functions. Today, plant-based proteins are gaining popularity as an alternative to meat-based proteins, and they can also offer high nutritional and medicinal benefits at a reasonable cost. Natural proteins are useful materials due to their safety, nutritional value, high biocompatibility, and low cost. Therefore, finding plant protein products rich in essential amino acids is of great significance to the food and pharmaceutical industries.

However, the natural structure of proteins lacks desirable functional properties and other important properties required for different systems, such as creams, minced meat products, confectionary and dairy products. To increase the function of proteins, various methods are used, such as chemical, enzymatic and physical—or a combination of these methods. The modification of food proteins is commonly used to alter the microstructure and physical properties of biopolymers used in food, medical and industrial applications.

This Special Issue will focus primarily on protein hydrolysates that have been isolated, characterized, modified and utilized from various sources. This research topic will provide a new direction for exploring these protein sources.

Dr. Michèle M. Iskandar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Current Issues in Molecular Biology is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • protein
  • hydrolysis
  • hydrolysis constant
  • inhibitor protein
  • polymer degradation
  • proteolysis

Published Papers (2 papers)

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Research

14 pages, 1598 KiB  
Article
Application of Normal-Phase Silica Column in Hydrophilic Interaction Liquid Chromatography Mode for Simultaneous Determination of Underivatized Amino Acids from Human Serum Samples via Liquid Chromatography–Tandem Mass Spectrometry
by Krisztina Németh, Ildikó Szatmári, Viktória Tőkési and Pál Tamás Szabó
Curr. Issues Mol. Biol. 2023, 45(12), 9354-9367; https://doi.org/10.3390/cimb45120586 - 22 Nov 2023
Viewed by 894
Abstract
In neonatal screening, amino acids have a significant diagnostic role. Determination of their values may identify abnormal conditions. Early diagnosis and continuous monitoring of amino acid disorders results in a better disease outcome. An easy and simple LC-MS/MS method was developed for the [...] Read more.
In neonatal screening, amino acids have a significant diagnostic role. Determination of their values may identify abnormal conditions. Early diagnosis and continuous monitoring of amino acid disorders results in a better disease outcome. An easy and simple LC-MS/MS method was developed for the quantitation of underivatized amino acids. Amino acids were separated using a normal-phase HPLC column having a totally porous silica stationary phase and using classical reversed-phase eluents. Mass spectrometry in multiple reaction monitoring mode was used for the analysis, providing high selectivity and sensitivity. A standard addition calibration model was applied for quantitation using only one isotope-labeled internal standard for all amino acids. Five calibration points were used for quantitation, and the method was successfully validated. The slopes of the calibration curves of the individual amino acids in parallel measurements were found to be similar. Since the measured slopes were reproducible, one serum sample could represent every series of serum samples of a given day. The method was tested on human serum samples and adequate results were obtained. This new method can be easily applied in clinical laboratories. Full article
(This article belongs to the Special Issue Protein Hydrolysates: Biological Activity and Applications)
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10 pages, 1188 KiB  
Article
A Fermented Wheat Germ Extract Contains Protein Components Active against NSCLC Xenografts In Vivo
by Daniel J. Levis, Joshua F. Meckler, Robert T. O’Donnell and Joseph M. Tuscano
Curr. Issues Mol. Biol. 2023, 45(9), 7087-7096; https://doi.org/10.3390/cimb45090448 - 25 Aug 2023
Viewed by 1763
Abstract
Non-small cell lung cancer (NSCLC) continues to be the leading cause of cancer-related deaths. Although advances have been made in the past decade to treat such tumors, most options induce multiple side effects, and many patients discontinue therapy due to toxicity. Thus, the [...] Read more.
Non-small cell lung cancer (NSCLC) continues to be the leading cause of cancer-related deaths. Although advances have been made in the past decade to treat such tumors, most options induce multiple side effects, and many patients discontinue therapy due to toxicity. Thus, the need remains for non-toxic, effective NSCLC therapies, especially in an elderly patient population. Our lab has previously identified a protein fraction from the nutraceutical Avemar®—dubbed fermented wheat germ protein (FWGP)—with demonstrated efficacy in lymphoma models both in vitro and in vivo. Here, we show that FWGP also has anti-tumor activity in vitro and in vivo against lung cancer. In vitro cytotoxicity against multiple lung cancer cell lines yielded IC50 values comparable to those previously established with the parent product, Avemar. Further, significant A549 xenograft growth inhibition occurred in athymic nu/nu mice receiving FWGP in both pre-radiated and non-radiated models when compared to the untreated control. Encouragingly, mice treated with FWGP experienced no toxicities as detected by weight reduction or blood chemistry analysis. These data support the further study of FWGP as a potential non-toxic therapy for lung cancer and other oncologic indications. Full article
(This article belongs to the Special Issue Protein Hydrolysates: Biological Activity and Applications)
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