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Dear Colleagues,

Skin inflammation is a sign of an immune response in the body, induced by multiple factors including allergies, infections and autoimmune diseases. The skin barrier can be repaired using ingredients such as lipids, fatty acids, and natural products and their active components. Plants have an abundance of active components and various phytochemicals with multiple benefits, including antioxidant properties, antiaging and protection of the skin from environmental damage.

The focus of this Special Issue is the improvement of skin-related problems through the application of natural products or their active components, including skin problems and related diseases caused by inflammation, aging, pigmentation, regulation of sebum and intracellular lipids, etc. In addition, regulation and mechanisms of the skin barrier function and the role of skin barrier function in skin problems will be discussed.

Prof. Dr. Hsiu-Mei Chiang
Guest Editor

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Keywords

skin inflammation
barrier function damage
natural compounds
antioxidant properties
antiaging

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Research

14 pages, 4637 KiB

Open AccessArticle

Kahweol Inhibits Pro-Inflammatory Cytokines and Chemokines in Tumor Necrosis Factor-α/Interferon-γ-Stimulated Human Keratinocyte HaCaT Cells

by Ye Jin Kwon, Hyun Hee Kwon, Jaechan Leem and Yoon Young Jang

Curr. Issues Mol. Biol. 2024, 46(4), 3470-3483; https://doi.org/10.3390/cimb46040218 - 18 Apr 2024

Viewed by 458

Abstract

Atopic dermatitis (AD), marked by intense itching and eczema-like lesions, is a globally increasing chronic skin inflammation. Kahweol, a diterpene that naturally occurs in coffee beans, boasts anti-inflammatory, antioxidative, and anti-cancer properties. This research explores the anti-inflammatory action of kahweol on HaCaT human keratinocytes stimulated by tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), focusing on key signal transduction pathways. Our results demonstrate that kahweol markedly reduces the production of IL-1β, IL-6, C-X-C motif chemokine ligand 8, and macrophage-derived chemokine in TNF-α/IFN-γ-activated HaCaT cells. Furthermore, it curtails the phosphorylation of key proteins in the mitogen-activated protein kinase (MAPK) pathways, including c-Jun N-terminal kinase, extracellular signal-regulated kinase, and p38. Additionally, kahweol impedes the phosphorylation and nuclear translocation of the NF-κB p65 subunit and constrains its DNA-binding capability. It also hampers the phosphorylation, nuclear translocation, and DNA-binding activities of signal transducer and activator of transcription 1 (STAT1) and STAT3. Collectively, these findings suggest that kahweol hinders the generation of cytokines and chemokines in inflamed keratinocytes by inhibiting the MAPK, NF-κB, and STAT cascades. These insights position kahweol as a promising agent for dermatological interventions, especially in managing inflammatory skin conditions such as AD. Full article

(This article belongs to the Special Issue Natural Product in Skin Inflammation and Barrier Function Damage)

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