The Prospect and Application of Electrochemical Biosensors

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "(Bio)chemical Sensing".

Deadline for manuscript submissions: closed (31 March 2024) | Viewed by 3947

Special Issue Editors

School of Life, Beijing Institute of Technology, Beijing Institute of Technology, Beijing 100081, China
Interests: electrochemical biosensors; microbial electrochemical systems; electrochemically active bacteria; nanomaterial; enviromental monitoring; water toxicity; water pollutants
College of Resources and Environment, Fujian Agriculture and Forestry University, Fuzhou 350002, China
Interests: bioelectrochemistry; microbial fuel cells; microbial electrolysis; electrochemically active biofilm; water biotoxicity monitoring

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Guest Editor
School of Chemistry, Sun Yet-sen University, Guangzhou 510275, China
Interests: electrochemical sensors; quantum electrochemistry; electrochemical measuring instrument; electronic package electrochemistry

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Guest Editor
College of Food Science and Engineering, Tianjin University of Science & Technology, Tianjin 300457, China
Interests: food science; food nutrition and safety; pesticide and veterinary drug testing; food harmful substances analysis
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Special Issue Information

Dear Colleagues,

Electrochemical biosensors, which are the combination of electrochemistry and biosensor technology, are novel and promising Chemosensors. The basic principle of electrochemical biosensors is utilizing biological components as sensing elements and accomplishing signal transition with electrochemical reactions. These biological components include enzymes, antibodies, nucleic acid, aptamer, whole cells, etc. Compared with typical chemical sensors, electrochemical biosensors can detect targets at low cost, with additional benefits such as simple operation, rapid response, and high specificity. These characteristics provide electrochemical biosensors with great prospects in the fields of environmental monitoring, disease diagnosis, and food-safety risk assessment.

Lately, due to significant progress in nano-material and micro-electrodes, the sensitivity and repeatability of electrochemical biosensors have enhanced. This provides a solid foundation for practical applications. In addition, as a result of in-depth research into environmental and molecular biology, a series of novel electrochemical biosensors have been reported. In this Special Issue, we would like to collect and discuss the prospects and applications of electrochemical biosensors. We welcome reviews and research articles related (but not limited) to the following topics:

  • Clinical biomarker, environmental indicator, and food component biomonitoring.
  • Novel target and biological recognition element.
  • Interface mechanisms of electrochemical biosensors.
  • Electrode surface treatment and coating.
  • Microelectrodes and interdigital electrodes.
  • Sensor configuration design.
  • Electrochemical detection method.
  • Electrical signal measurement and treatment.
  • Electrochemical biosensor application and challenge.

Dr. Yue Yi
Dr. Yong Jiang
Dr. Guofeng Cui
Dr. Mingfei Pan
Guest Editors

Manuscript Submission Information

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Keywords

  • electrochemistry
  • biosensor
  • sensing electrode
  • biological recognition element
  • electrode surface
  • electrochemical analysis
  • nanomaterial
  • biomarker validation
  • pollutant assessment
  • food-safety hazard

Published Papers (2 papers)

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Research

11 pages, 3094 KiB  
Article
Acetylcholinesterase Immobilization on ZIF-8/Graphene Composite Engenders High Sensitivity Electrochemical Sensing for Organophosphorus Pesticides
by Long Wen, Ning Wang, Zhuoliang Liu, Cheng-an Tao, Xiaorong Zou, Fang Wang and Jianfang Wang
Chemosensors 2022, 10(10), 418; https://doi.org/10.3390/chemosensors10100418 - 13 Oct 2022
Cited by 6 | Viewed by 1599
Abstract
A sensitive and flexible detection method for organophosphorus pesticides (OPs) detection is a crucial request to avoid their further expanded pollution. Herein, an acetylcholinesterase (AChE) electrochemical sensor, based on the co-modification of ZIF-8 and graphene (GR), was constructed for the detection of OPs. [...] Read more.
A sensitive and flexible detection method for organophosphorus pesticides (OPs) detection is a crucial request to avoid their further expanded pollution. Herein, an acetylcholinesterase (AChE) electrochemical sensor, based on the co-modification of ZIF-8 and graphene (GR), was constructed for the detection of OPs. ZIF-8/GR composite can provide a stable and biocompatible environment for the loading of AChE and can accelerate the chemical reaction on the electrode surface. After optimization, the linear detection range of the constructed AChE-CS/GR/ZIF-8/GCE sensor for ICP was 0.5–100 ng/mL (1.73–345.7 nM), and the limit of detection was 0.18 ng/mL (0.62 nM). Moreover, high sensitivity and high specificity of the sensor were also achieved in actual cabbage and tap water samples. Therefore, it has great potential for the application of organophosphorus pesticide residue analysis. Full article
(This article belongs to the Special Issue The Prospect and Application of Electrochemical Biosensors)
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10 pages, 1748 KiB  
Communication
YAP/TAZ Promote Fibrotic Activity in Human Trabecular Meshwork Cells by Sensing Cytoskeleton Structure Alternation
by Shan Huang, Zhicheng Liu, Xiuqing Qian, Lin Li, Haixia Zhang, Shanshan Li and Zhicheng Liu
Chemosensors 2022, 10(7), 235; https://doi.org/10.3390/chemosensors10070235 - 21 Jun 2022
Cited by 2 | Viewed by 1449
Abstract
Trabecular meshwork (TM) is the main channel of aqueous humor (AH) outflow and the crucial tissue responsible for intraocular pressure (IOP) regulation. The aberrant fibrotic activity of human TM (HTM) cells is thought to be partially responsible for the increased resistance to AH [...] Read more.
Trabecular meshwork (TM) is the main channel of aqueous humor (AH) outflow and the crucial tissue responsible for intraocular pressure (IOP) regulation. The aberrant fibrotic activity of human TM (HTM) cells is thought to be partially responsible for the increased resistance to AH outflow and elevated IOP. This study aimed to identify the TM cell fibrotic activity biomarker and illustrate the mechanisms of fibrotic activity regulation in HTM cells. We used TGFβ2-treated HTM cells and detected the changes in the cytoskeletal structure, the Yes-associated protein (YAP) and its transcriptional co-activator with PDZ-binding domain (TAZ) activation, and the expression levels of the fibrosis-related proteins Collagen I and α-SMA in HTM cells by immunofluorescence staining or western bolt analyses. The expression of YAP was inhibited using siRNA transfection. The results showed that the expression levels of YAP/TAZ and the fibrosis-related proteins Collagen I and α-SMA in HTM cells were elevated under TGF-β2 treatment, which was correlated with the structural change of the cellular F-actin cytoskeleton. Furthermore, the inhibition of YAP decreased the expression of connective tissue growth factor (CTGF), Collagen I, and α-SMA in HTM cells. These findings demonstrate that YAP/TAZ are potential biomarkers in evaluating the TM cell fibrotic activity, and it could sense cytoskeletal structure cues and regulate the fibrotic activity of TM cells. Full article
(This article belongs to the Special Issue The Prospect and Application of Electrochemical Biosensors)
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