Biomimetic and Chemical Sensors Based on Molecularly Imprinted Polymers (MIPs)

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Materials for Chemical Sensing".

Deadline for manuscript submissions: closed (30 March 2024) | Viewed by 6182

Special Issue Editors


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Guest Editor
Department of Chemistry, University of Pavia, 27100 Pavia, Italy
Interests: electrochemistry; forensic chemistry; biochemistry

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Guest Editor
Department of Chemistry, University of Pavia, 27100 Pavia, Italy
Interests: molecularly imprinted polymers; solid sorbents; colourimetric sensors; ion and chelating resins; electroanalytical techniques; metal ions complexes
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Special Issue Information

Dear Colleagues,

Molecularly imprinted polymers (MIPs) are synthesized as very versatile biomimetic receptors for sensing several analytes. They are successfully applied to a wide range of fields, from medicine and diagnostics to environmental quality monitoring, food controls and forensic analysis.

Several strategies have been employed to face MIPs with different transducers, aiming to develop sensitive and selective chemical and biochemical sensors.

The Special Issue is intended as a collection of the latest research and advancements in the field, titled “Biomimetic and Chemical sensors based on Molecularly Imprinted Polymers (MIPs)”, focusing on recent and novel transduction methods in MIP-based sensors. Both review articles and original research papers are welcome, including but not limited to the following areas:

  • Novel applications of MIP-based (bio-)chemosensors;
  • MIP-based nanoplatforms and chips;
  • New techniques for facing MIP to different transducers;
  • Chemometric approach for optimization and treatment of data derived from MIP-based sensors and array;
  • Critical reviews of the state-of-art and current trends of MIP-based sensing.

Dr. Daniele Merli
Dr. Giancarla Alberti
Guest Editors

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Keywords

  • novel applications of MIP-based (bio-)chemosensors
  • MIP-based nanoplatforms and chips
  • new techniques for facing MIP to different transducers
  • chemometric approach for optimization and treatment of data derived from MIP-based sensors and array
  • critical reviews of the state-of-art and current trends of MIP-based sensing

Published Papers (4 papers)

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Research

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13 pages, 3251 KiB  
Article
MIP-Assisted 3-Hole POF Chip Faced with SPR-POF Sensor for Glyphosate Detection
by Giancarla Alberti, Stefano Spina, Francesco Arcadio, Maria Pesavento, Letizia De Maria, Nunzio Cennamo, Luigi Zeni and Daniele Merli
Chemosensors 2023, 11(7), 414; https://doi.org/10.3390/chemosensors11070414 - 22 Jul 2023
Cited by 1 | Viewed by 1001
Abstract
The present study proposes the application of a recently developed optical–chemical sensor system to glyphosate detection. The device probes the refractive index variation in a chip based on a plastic optical fiber (POF) in which three orthogonal micro-holes were created and filled with [...] Read more.
The present study proposes the application of a recently developed optical–chemical sensor system to glyphosate detection. The device probes the refractive index variation in a chip based on a plastic optical fiber (POF) in which three orthogonal micro-holes were created and filled with an acrylic-based molecularly imprinted polymer (MIP). This sensitive chip, connected in series to a gold-coated SPR-POF platform, can modify the surface plasmon resonance (SPR) phenomena by exploiting the multimode characteristic of the POFs. Therefore, the gold film of the SPR-POF platform is not covered by the MIP layer, improving the sensor’s performance because the interaction between the analyte (glyphosate) and the polymer recognition cavities occurs in the core and not in the cladding of the waveguide. Indeed, the sample solution is dropped on the MIP-based chip while a water drop is constantly maintained above the gold surface of the reference SPR-POF platform to excite the surface plasmons, modulated by the MIP interaction with the target analyte. The device is here for the first time applied for glyphosate sensing in water samples. The high sensitivity and selectivity are proven, and tests on real samples highlight the good performances of the developed sensors. Full article
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11 pages, 1810 KiB  
Article
A Facile Surface-Imprinting Strategy for Trypsin-Imprinted Polymeric Chemosensors Using Two-Step Spin-Coating
by Je Wook Byeon, Jin Chul Yang, Chae Hwan Cho, Seok Jin Lim, Jong Pil Park and Jinyoung Park
Chemosensors 2023, 11(3), 189; https://doi.org/10.3390/chemosensors11030189 - 11 Mar 2023
Cited by 3 | Viewed by 1533
Abstract
Surface imprinting used for protein recognition in functional cavities is highly effective in imprinting biomacromolecules to avoid template encapsulation during the formation of a molecularly imprinted polymer (MIP) matrix. Herein, we introduce a facile surface-imprinting method based on two-step spin-coating and photopolymerization to [...] Read more.
Surface imprinting used for protein recognition in functional cavities is highly effective in imprinting biomacromolecules to avoid template encapsulation during the formation of a molecularly imprinted polymer (MIP) matrix. Herein, we introduce a facile surface-imprinting method based on two-step spin-coating and photopolymerization to design highly efficient imprinted sites on polymeric films to detect trypsin (TRY). Well-distributed template imprinting is successfully achieved for maximized sensing responses by controlling the composition of functional monomers and crosslinkers in the precursor solution and the concentration of TRY in the imprinting solution. The MIP film exhibits higher sensitivity (−841 ± 65 Hz/(μg/mL)) with a coefficient of determination of 0.970 and a higher imprinting factor of 4.5 in a 0.24 µg/mL TRY solution compared to the nonimprinted polymer (NIP) film. Moreover, the limit of detection and limit of quantification are calculated to be 25.33 and 84.42 ng/mL, respectively. Finally, the selectivity coefficient is within the range of 3.90–6.78 for TRY against other proteins. These sensing properties are superior to those of the corresponding nonimprinted polymer matrix. Thus, the proposed facile surface-imprinting method is highly effective for protein imprinting with high sensitivity and selectivity. Full article
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Review

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22 pages, 4134 KiB  
Review
Synergism between Graphene and Molecularly Imprinted Polymers in Developing Electrochemical Sensors for Agri-Food and Environmental Analyses
by Gabriel-Lucian Radu, Simona Carmen Lițescu, Alin Enache, Camelia Albu and Sandra A. V. Eremia
Chemosensors 2023, 11(7), 380; https://doi.org/10.3390/chemosensors11070380 - 07 Jul 2023
Cited by 3 | Viewed by 1200
Abstract
In recent years, new sensor-based technologies have been developed to meet the demand for rapid and accurate analysis of food and environment, as food safety and environmental monitoring are very important concerns nowadays. In this context, considerable attention has been paid to the [...] Read more.
In recent years, new sensor-based technologies have been developed to meet the demand for rapid and accurate analysis of food and environment, as food safety and environmental monitoring are very important concerns nowadays. In this context, considerable attention has been paid to the development and design of electrochemical sensors, as these offer a number of advantages, such as portability, ease of use, low costs and fast response times. Molecularly imprinted polymers (MIPs) are robust synthetic polymers with special cavities designed for a target molecule, and they are used as selective tools through a mechanism of molecular recognition. Graphene is a 2D crystalline carbon that forms either a single or a coupled layer of hexagonally arranged carbon atoms and is referred to as a “wonder material”. The use of these two structures in the development of electrochemical sensors gives the newly created analytical tool enhanced properties, such as improved sensitivity and selectivity, low detection limit, good stability and reusability. This review presents an overview of the recent research regarding the use of MIPs and graphene in the development of electrochemical sensors for food and environmental analyses, critically discusses the pros and cons, and gives perspectives for further developments in this field. Full article
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26 pages, 2888 KiB  
Review
Conductive Molecularly Imprinted Polymers (cMIPs): Rising and Versatile Key Elements in Chemical Sensing
by Adriana Feldner, Julia Völkle, Peter Lieberzeit and Philipp Fruhmann
Chemosensors 2023, 11(5), 299; https://doi.org/10.3390/chemosensors11050299 - 18 May 2023
Cited by 1 | Viewed by 1686
Abstract
Molecularly imprinted polymers (MIPs) have proven useful as receptor materials in chemical sensing and have been reported for a wide range of applications. Based on their simplicity and stability compared to other receptor types, they bear huge application potential related to ongoing digitalization. [...] Read more.
Molecularly imprinted polymers (MIPs) have proven useful as receptor materials in chemical sensing and have been reported for a wide range of applications. Based on their simplicity and stability compared to other receptor types, they bear huge application potential related to ongoing digitalization. This is the case especially for conductive molecularly imprinted polymers (cMIPs), which allow easy connection to commercially available sensing platforms; thus, they do not require complex measuring setups. This review provides an overview of the different synthetic approaches toward cMIPs and the obtained limit of detections (LODs) with different transducing systems. In addition, it presents and discusses their use in different application areas to provide a detailed overview of the challenges and possibilities related to cMIP-based sensing systems. Full article
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