Application and Advance of Optical Immunosensors

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Optical Chemical Sensors".

Deadline for manuscript submissions: 29 February 2024 | Viewed by 3987

Special Issue Editors

School of Physics, Engineering and Technology, University of York, Heslington, York YO10 5DD, UK
Interests: optical biosensing; metasurface; metalens; photonic devices; nanotechnology

Special Issue Information

Dear Colleagues,

The immune sensor community has been experiencing rapid growth in the last decades. The immune sensor has the ability to identify target antigens quickly and generate immunocomplexes without the need to add supplementary reagents. Due to its excellent detection performance in terms of specificity and sensitivity, it has become a popular analytical instrument. Especially in recent years, digital and miniaturization of immunosensors are widely applied for the detection of various pathogens. Among the commonly used immunosensors, the optical immunosensor features prominently as an effective tool for the quantification of the number of antibodies, antigens, or haptens in complex samples with high sensitivity and specificity. This Special Issue will focus on the latest advances in optical immune sensors for proof of art demonstration or clinical analysis. Both review articles and novel research papers are solicited, covering the following areas:

(1) Novel optical sensors or platforms that could observe an immune response, direct or indirect, i.e., through observation of binding events or from fluorescence detection.

(2) Optical sensors that could improve the sensitivity, accuracy and precision of biomedical analysis and diagnostics.

(3) Optimisation of fabrication process, data processing strategies, and consistency to improve the performance of optical immunosensors.

(4) The combination of optical sensors with different technologies (i.e., electrical, acoustics, magnetic) to enable multiparameter and multiplexed sensing.

(5) Comprehensive overviews of optical immunosensors.

Dr. Kezheng Li
Dr. Donato Conteduca
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Published Papers (2 papers)

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Research

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13 pages, 4850 KiB  
Article
Specific and Sensitive Determination of Folic Acid by Label-Free Chemosensors with Microscope Glass Slips as Single-Use Consumables
Chemosensors 2023, 11(1), 17; https://doi.org/10.3390/chemosensors11010017 - 24 Dec 2022
Cited by 4 | Viewed by 1710
Abstract
Folic acid (FA) and its other forms known as folates are small molecules vital for humans. The high demand for increasingly sensitive methods of measuring folate concentrations is due to the fact that abnormal levels of FA cause severe health disorders. Besides, folates [...] Read more.
Folic acid (FA) and its other forms known as folates are small molecules vital for humans. The high demand for increasingly sensitive methods of measuring folate concentrations is due to the fact that abnormal levels of FA cause severe health disorders. Besides, folates are used as recognition molecules in targeted drug delivery. The majority of FA measuring techniques are rather expensive, laborious, sometimes not sufficiently sensitive and specific, and often employ consumables that are too costly to be single-use for routine medical diagnostics. Here, we present a procedure for transformation of a simple microscope cover glass slip without deposition of any metal or dielectric films into a cost-efficient chemosensor chip interrogated by spectral correlation interferometry for highly sensitive measurements of the concentration of small molecules, as well as a feasibility study of long-term monitoring of such molecules in a flow mode. The obtained chips were tested for folate detection. The highly specific and sensitive measurements can be performed in real-time in a wide dynamic range of 0.9–220,000 pM. The developed method and single-use consumables are promising for concentration measurements of low molecular weight substances in pharmaceuticals and in vitro diagnostics. Full article
(This article belongs to the Special Issue Application and Advance of Optical Immunosensors)
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Review

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36 pages, 4557 KiB  
Review
Smartphone-Based Portable Bio-Chemical Sensors: Exploring Recent Advancements
Chemosensors 2023, 11(9), 468; https://doi.org/10.3390/chemosensors11090468 - 22 Aug 2023
Cited by 2 | Viewed by 1725
Abstract
Traditionally, analytical chemistry and diagnosis relied on wet laboratories and skilled professionals utilizing sophisticated instruments for sample handling and analysis. However, with the development of novel materials and sensing techniques, there has been a significant shift towards the use of standalone sensors, allowing [...] Read more.
Traditionally, analytical chemistry and diagnosis relied on wet laboratories and skilled professionals utilizing sophisticated instruments for sample handling and analysis. However, with the development of novel materials and sensing techniques, there has been a significant shift towards the use of standalone sensors, allowing tests to be conducted on-site or even in real time, leading to cost- and time-efficiency. With their widespread adoption globally, smartphones have emerged as an ideal platform for such sensors, boasting extensive sensor capabilities, advanced processing power, and communication functionalities. Smartphone-based assays make use of optical and electrochemical sensors, utilizing built-in cameras, ambient light sensors, and other features for optical sensing, while the micro-USB port, Bluetooth, and wireless connection facilitate data transmission and analog voltage application for electrochemical sensing. Previous overview papers have explored smartphone-based sensing in specific domains; this review provides a comprehensive examination of recent advancements in smartphone-based sensors, encompassing both optical and electrochemical sensing methods. The review provides the fundamental principles of these sensors and their implementation using smartphones, showcases recent applications, and presents innovative designs that take advantage of the inherent functionalities and sensor capabilities of smartphones. The review concludes by offering an outlook on the prospects of smartphone-based sensing and includes a reflective section emphasizing the potential impact of sensors in chemical and biological analyses. This comprehensive resource aims to provide information to researchers and practitioners interested in using smartphones for cutting-edge analytical methodologies. Full article
(This article belongs to the Special Issue Application and Advance of Optical Immunosensors)
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