Diversity in Sensing Applications of Porphyrin or Other Macrocyclic Compound-Based Materials

A special issue of Chemosensors (ISSN 2227-9040). This special issue belongs to the section "Applied Chemical Sensors".

Deadline for manuscript submissions: closed (20 November 2023) | Viewed by 12295

Special Issue Editors


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Guest Editor
Institute of Chemistry “Coriolan Dragulescu” of Romanian Academy, Mihai Viteazul Ave., No. 24 RO-300223, Timisoara, Romania
Interests: porphyrins; metalloporphyrins; porphyrin-based hybrid materials; AuNPs, AgNPs, and PtNPs; chemical and electrochemical sensors; detection of analytes with medical relevance; catalysts
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Guest Editor
Faculty of Chemistry, Biology, Geography, West University of Timisoara, 4 V. Parvan Ave, 300223 Timisoara, Romania
Interests: ion-selective electrode; potentiometry; analytes with medical relevance; heavy metal ions; PVC membrane; pharmaceuticals

Special Issue Information

Dear Colleagues,

Porphyrin derivatives are versatile structures highly recognized for their capacity to distort from their planar geometry and to act as building blocks for a large variety of supramolecular architectures realized through noncovalent interactions. Moreover, functionalized porphyrins possess the desired chemical, optical, electronic and morphological properties that recommend them for use in the formulation of sensors and biosensors.

This Special Issue focuses on both bare porphyrins, heteroatom-containing porphyrin dimeric structures, porphyrin-based metal–organic frameworks and on other porphyrin-based materials designed to enhance the envisaged properties of porphyrins through synergistically added effects as a result of their interaction with other porphyrin molecules, noble metal nanoparticles or following their incorporation into polymers or organic or inorganic (zeolites or silica) matrices.

Greater consideration will be given to the obtainment and characterization of sensitive porphyrin-based materials and other macrocyclic compounds (crown ethers, calixarenes, cyclodextrins, cucurbiturils and cavitands) no matter if they belong to hybrid or composite materials, to the selection criteria of the best materials, construction details of sensors and biomedical nanodevice preparations and understanding types of interactions with analytes up to the establishment of detection mechanisms.

Due to their performance as amazing host compounds for the selective and sensitive detection of various chemical species, macrocyclic compounds are capable of forming coordination complexes with a large variety of metal ions, potential hazardous biomaterials, amino acids, neurotransmitters, vitamins, pharmaceuticals, relevant compounds for human health monitoring (amino acids, glucose, uric acid, iodide, peroxide species, antibodies, nucleic acids, DNA, peptides, etc.) and even gases.

The main aim of this Special Issue is to envisage the progress in biomedicine and monitor human health parameters by using macrocyclic compound derivatives as receptors or signaling molecules. The guest editors invite both original articles and reviews covering the field of chemical, electrochemical, optical and resistive sensor devices.

Dr. Eugenia Fagadar-Cosma
Dr. Dana Vlascici
Guest Editors

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Keywords

  • porphyrins
  • other macrocyclic compounds (crown ethers, calixarenes and cyclodextrins)
  • porphyrin or macrocyclic compound-based materials
  • optical chemical sensors
  • fluorescence sensors
  • ion-selective electrodes
  • electrochemical sensors
  • screen-printed microelectrodes
  • detection of analytes with biomedical relevance
  • hazardous chemicals
  • metal ion detection
  • amino acids detection
  • pharmaceuticals detection
  • detection of gases

Published Papers (5 papers)

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Research

13 pages, 1691 KiB  
Article
Dilute-and-Shoot-Liquid Chromatography-Quadrupole Time of Flight-Mass Spectrometry for Pteridine Profiling in Human Urine and Its Association with Different Pathologies
by Claudia Giménez-Campillo, Marta Pastor-Belda, Natalia Arroyo-Manzanares, Natalia Campillo, Blanca del Val Oliver, José Zarauz-García, Luis Sáenz and Pilar Viñas
Chemosensors 2023, 11(6), 324; https://doi.org/10.3390/chemosensors11060324 - 01 Jun 2023
Viewed by 1295
Abstract
Pteridines are a group of compounds synthesised by many living organisms that are involved in the metabolism of many cofactors and vitamins. Their concentration in biological fluids may be altered by various pathologies such as cancer or inflammatory bowel disease, urine being the [...] Read more.
Pteridines are a group of compounds synthesised by many living organisms that are involved in the metabolism of many cofactors and vitamins. Their concentration in biological fluids may be altered by various pathologies such as cancer or inflammatory bowel disease, urine being the main route of excretion. In this study, three lumazines and ten pterins were analysed in their native oxidation state using high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. Their high concentration in urine samples and their good ionisation behaviour allow the use of the dilute-and-shoot method by simple filtration of the urine prior to chromatographic analysis. The final method offers excellent linearity, sensitivity and precision parameters, and a total of 135 urine samples were analysed from patients with some relevant information such as faecal calprotectin (FCP) levels, common diseases such as diabetes, hypertension and dyslipidaemia and immunological diseases such as inflammatory bowel disease (IBD). The pteridine profile was related to FCP levels without showing any correlation. In addition, pteridine levels were compared between healthy subjects and IBD, diabetic, hypertensive and dyslipidaemic patients, and significant differences were found between the two groups for some of the pteridines. Full article
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17 pages, 4051 KiB  
Article
Ion Mobility Spectrometry for the Metabolomic Study of Inflammatory Bowel Disease Using the Volatile Organic Compounds Profile in Human Serum and Urine
by María García-Nicolás, María Carmen Pérez-Álvarez, Fuensanta Abellán-Alfocea, Natalia Arroyo-Manzanares, Natalia Campillo, Blanca del Val-Oliver, Enrique Jiménez-Santos, José Zarauz-García, Luis Sáenz and Pilar Viñas
Chemosensors 2023, 11(2), 139; https://doi.org/10.3390/chemosensors11020139 - 14 Feb 2023
Cited by 1 | Viewed by 1462
Abstract
Inflammatory bowel disease (IBD) is an immune-mediated disease characterized by chronic mucosal inflammation of the digestive tract. The IBD diagnosis is currently based on the results of imaging, clinical, and histopathological tests. The gold standard diagnostic method is endoscopy, an invasive imaging technique [...] Read more.
Inflammatory bowel disease (IBD) is an immune-mediated disease characterized by chronic mucosal inflammation of the digestive tract. The IBD diagnosis is currently based on the results of imaging, clinical, and histopathological tests. The gold standard diagnostic method is endoscopy, an invasive imaging technique that requires patient sedation and prior bowel preparation and is expensive. In the present work, monitoring the volatile compound fingerprint of serum and urine by headspace gas chromatography-ion mobility spectrometry (HS-GC-IMS) is presented as a rapid and reliable diagnostic complementary test for patients with IBD. The analytical method was optimized and applied for the analysis of serum (118) and urine (123) samples from patients with IBD (in remission and active phase of the disease) and healthy volunteers without IBD. Orthogonal partial least square discriminant analysis was performed using all the integrated markers present in the topographic maps of each sample type, allowing the differentiation between healthy IBD volunteers and IBD patients and between IBD status (remission or active). The individual study of markers allowed the identification and quantification of twelve and six compounds in urine and serum samples, respectively. This information was further used to perform a one-way analysis of variance to compare the different categories. Full article
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17 pages, 2459 KiB  
Article
Asymmetric Pt(II)-Porphyrin Incorporated in a PVC Ion-Selective Membrane for the Potentiometric Detection of Citrate
by Dana Vlascici, Anca Lascu, Ion Fratilescu, Diana Anghel, Camelia Epuran, Mihaela Birdeanu, Vlad Chiriac and Eugenia Fagadar-Cosma
Chemosensors 2023, 11(2), 108; https://doi.org/10.3390/chemosensors11020108 - 02 Feb 2023
Cited by 1 | Viewed by 1188
Abstract
A new sensing material, Pt(II)-5-(4-carboxyphenyl)-10,15,20-tris(4-phenoxyphenyl)-porphyrin (Pt(II)-COOH-TPOPP), was synthesized and characterized. Polymeric membranes containing the porphyrin and three different plasticizers were used as an electroactive material for a new anion-selective sensor. The best composition of the membrane was the one plasticized with dioctylsebacate (DOS), [...] Read more.
A new sensing material, Pt(II)-5-(4-carboxyphenyl)-10,15,20-tris(4-phenoxyphenyl)-porphyrin (Pt(II)-COOH-TPOPP), was synthesized and characterized. Polymeric membranes containing the porphyrin and three different plasticizers were used as an electroactive material for a new anion-selective sensor. The best composition of the membrane was the one plasticized with dioctylsebacate (DOS), the obtained sensor being citrate-selective in a linear range of 5 × 10−7–1 × 10−1 M citrate. The slope was Nernstian (19.73 mV/decade) with good selectivity towards a number of interfering anions and a lifetime of five weeks. Full article
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7 pages, 2914 KiB  
Communication
Ninhydrin Loaded Microcapsules for Detection of Natural Free Amino Acid
by Suhui Jeong, Yeji Jeon, Jaehun Mun, Se Min Jeong, Huiling Liang, Kyeongwoon Chung, Pyong-In Yi, Beum-Soo An and Sungbaek Seo
Chemosensors 2023, 11(1), 49; https://doi.org/10.3390/chemosensors11010049 - 05 Jan 2023
Cited by 1 | Viewed by 5822
Abstract
Natural free amino acids present in plant extracts or tea infusions provide a unique flavor and potential effect on anxiety and blood pressure reduction. Accordingly, quantifying free amino acids in foods has been of interest to food science and analytical research fields. The [...] Read more.
Natural free amino acids present in plant extracts or tea infusions provide a unique flavor and potential effect on anxiety and blood pressure reduction. Accordingly, quantifying free amino acids in foods has been of interest to food science and analytical research fields. The ninhydrin solution-based assay is a colorimetric method based on the formation and detection of Ruhemann’s purple complex. Media-based colorimetric detection requires specialized facilities and personnel; moreover, it can suffer from the interference of the analyte color. In this study, we developed ninhydrin-loaded microcapsules and a simple free amino acids detection procedure, by simply dipping the microcapsules into the analyte solution for 3 min. Among the five tested natural free amino acids, theanine exhibited the highest colorimetric response to microcapsule-based detection, with a limit of detection of 0.826 mM. Full article
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14 pages, 781 KiB  
Article
Simple, Accurate and Multianalyte Determination of Thirteen Active Pharmaceutical Ingredients in Polypills by HPLC-DAD
by Barbara Żuromska-Witek, Mariusz Stolarczyk, Marek Szlósarczyk, Szymon Kielar and Urszula Hubicka
Chemosensors 2023, 11(1), 25; https://doi.org/10.3390/chemosensors11010025 - 28 Dec 2022
Cited by 3 | Viewed by 1846
Abstract
A new universal HPLC-DAD method has been developed for the separation and simultaneous determination of thirteen active pharmaceutical ingredients (APIs): ramipril, lisinopril, enalapril; atenolol, metoprolol; losartan, candesartan; rosuvastatin, atorvastatin, simvastatin; amlodipine; hydrochlorothiazide, acetylsalicylic acid in polypills used in the treatment of hypertension. The [...] Read more.
A new universal HPLC-DAD method has been developed for the separation and simultaneous determination of thirteen active pharmaceutical ingredients (APIs): ramipril, lisinopril, enalapril; atenolol, metoprolol; losartan, candesartan; rosuvastatin, atorvastatin, simvastatin; amlodipine; hydrochlorothiazide, acetylsalicylic acid in polypills used in the treatment of hypertension. The chromatographic analysis of the APIs was performed on an ACE-5 C18-PFP column (250 mm × 4.6 mm, 5 μm) with 0.01 M phosphate buffer (pH = 2.50) and acetonitrile in gradient elution as the mobile phase at a flow rate 1.0 mL min−1. UV detection was performed at 230 nm. The analysis time was 35 min. The elaborated method meets the acceptance criteria for specificity, linearity, sensitivity, accuracy, and precision for all examined substances. The linearity range was observed in a wide concentration range, whereas the determination coefficients (R2) for the linear model were greater than 0.990. The sensitivity of the method was good with the LOD and LOQ values ranged from 0.0009 to 0.0923 mg mL−1 and from 0.0027 to 0.2794 mg mL−1, respectively. The proposed method showed good precision with RSD less than 1.91% and the accuracy expressed as percent recovery was from 95.20% to 104.62%. The proposed HPLC-DAD method was successfully applied to determine APIs in prepared model mixtures corresponding to the commercially available polypill tablets. The obtained results of the measured contents were with good accuracy (95.84–103.92%) and high precision (RSD < 0.95%) indicating the applicability of the proposed method for the simultaneous determination of the polypill components. Therefore, the method can be an effective tool in the quality control of polypills. Full article
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