Special Issue "Targeting Therapies for the p53 Protein in Cancer Treatments"
Deadline for manuscript submissions: closed (31 May 2023) | Viewed by 13268
The tumour suppressor protein p53 was discovered over 40 years ago and is arguably one of the most important proteins protecting us from developing tumours. In response to stress, p53 decides whether the stress is severe enough to destroy the cell or whether a repair program is initiated. Decreased p53 function strongly increases the chances of developing cancers and in more than half of all human cancers, the p53 gene is found to be mutated. Gene mutations lead to the complete loss of protein expression or to the expression of mutant forms of p53. Hundreds of different mutant p53 proteins are found in human cancers. Some display a loss of wildtype function, and others gain novel functions in promoting metastasis and chemoresistance, but the majority will display a combination of both to varying degrees. Although advances have been made recently, no strategies targeting p53 are in routine use in clinical practice. Many proposed targeting therapies aim to restore or increase wildtype p53 function. Others aim to make use of vulnerabilities caused by a loss of p53 function or mutant p53 expression.
In this Special Issue, we will discuss the differences between these targeting strategies and explore at what stage of drug development they are.
Dr. Patricia A.J. Muller
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- p53 mutation
- targeted therapy
- small molecules
- MDM2/ MDMX inhibition