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Cancers
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Skin Cancer: Epidemiology, Prevention and Quality of Life
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Skin Cancer: Epidemiology, Prevention and Quality of Life

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Epidemiology and Prevention".

Deadline for manuscript submissions: closed (20 July 2023) | Viewed by 8680

Special Issue Editor

Dr. Sabela Paradela

E-Mail Website
Guest Editor
Dermatology Department, Hospital Abente y Lago, Complejo Hospitalario Universitario A Coruña, Coruña, Spain
Interests: melanoma; prevention; life

Special Issue Information

Dear Colleagues,

Cutaneous malignancy is the most common human cancer. Its incidence has been steadily increasing over the past four decades, becoming a public health burden in terms of morbidity and cost. This rising trend is associated with changing environmental exposures and the increased longevity of the general and the immunosuppressed population.

This Special Issue will focus on the epidemiology, prevention, and impairment of quality of life due to skin cancer, primarily by addressing the following issues:

  • Differential features of skin cancer in special groups: the elderly, children, the immunosuppressed and pregnancy.
  • The impact of new therapies for skin cancer on quality of life, specifically the differences in the cosmetic and functional outcome of patients treated with Mohs micrographic surgery compared to conventional surgery.
  • The prevention and follow-up of skin tumours in genodermatoses with risk of malignancy.
  • The risk and prevention of skin cancer in dermatological therapies.
  • The prevention of new melanomas in patients with melanoma.

We warmly welcome submissions, including original papers and systematic reviews.

Dr. Sabela Paradela
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • melanoma
  • cutaneous squamous cell carcinoma
  • basal cell carcinoma
  • Merkel cell carcinoma
  • epidemiology
  • quality of life
  • prevention

Published Papers (5 papers)

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Research

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7 pages, 174 KiB  
Article
Mortality from Nonmelanoma Skin Cancer in Australia from 1971 to 2021
by D. Czarnecki
Cancers 2024, 16(5), 867; https://doi.org/10.3390/cancers16050867 - 21 Feb 2024
Viewed by 659
Abstract
The number of non-melanoma skin cancers (NMSC) removed from Australians is increasing every year. The number of deaths from NMSC is increasing but so is the population. However, the population has greatly changed with many dark-skinned people migrating to Australia. These people are [...] Read more.
The number of non-melanoma skin cancers (NMSC) removed from Australians is increasing every year. The number of deaths from NMSC is increasing but so is the population. However, the population has greatly changed with many dark-skinned people migrating to Australia. These people are at low risk for skin cancer even if they live all their lives in Australia. The susceptible population is the rest of the population. The death rate from NMSC for the entire population and susceptible populations since 1971 is examined in this article. Materials and methods: Data on the Australian population were obtained from the Australian Bureau of Statistics (ABS). Every five years a census is held in Australia and detailed information of the population is provided. The ABS also provided yearly data on the causes of death in Australia. Results: The total population increased from 12,755,638 in 1971 to 25,738,140 in 2021. However, the susceptible population increased by far less, from 12,493,780 to 19,773,783. The number of deaths from NMSC increased from 143 to 765. The crude death rate for the susceptible population increased from 1.1 per 100,000 to 3.9 per 100,000. The crude death rate in the susceptible population aged 65 or more increased from 9.4 to 18.2 per 100,000. Conclusion: Deaths from NMSC are increasing despite public health campaigns to prevent skin cancer. According to current trends, NMSC will cause more deaths than melanoma in Australia. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Prevention and Quality of Life)
11 pages, 2379 KiB  
Article
Merkel Cell Carcinoma of the External Ear: Population-Based Analysis and Survival Outcomes
by André S. Alves, Matteo Scampa, Jérôme Martineau, Salvatore Giordano, Daniel F. Kalbermatten and Carlo M. Oranges
Cancers 2022, 14(22), 5653; https://doi.org/10.3390/cancers14225653 - 17 Nov 2022
Cited by 2 | Viewed by 1532
Abstract
(1) Background: Due to its highly aggressive behavior, the ability to identify and manage Merkel Cell Carcinoma (MCC) with a full understanding of its characteristics is essential. Because the external ear is an exposed area, resection can have dramatic consequences on patient’s [...] Read more.
(1) Background: Due to its highly aggressive behavior, the ability to identify and manage Merkel Cell Carcinoma (MCC) with a full understanding of its characteristics is essential. Because the external ear is an exposed area, resection can have dramatic consequences on patient’s self-image, which is why it is fundamental to detect MCC, typically found on UV-exposed regions such as the ears, at an early stage. (2) Methods: The Surveillance, Epidemiology, and End Results (SEER) database was searched for all external ear MCC between 2000 and 2019. A descriptive analysis based on frequencies was made to describe the demography of pathophysiologic features linked to MCC. Overall survival (OS) was studied and compared between variables with a log rank test. A multivariable Cox regression analysis was then computed to identify independent prognostic factors. (3) Results: A total of 210 patients (160 men) were identified with a median age of 80 years. The median OS was 47 months. Factors associated with lower OS included an age of over 80 years, the male gender, a tumor size of >5 cm, and metastatic disease. Gross (<1 cm) and wide (>1 cm) surgery excision margins were the surgery types with the best OS. (4) Conclusions: MCC of the external ear is diagnosed mostly in old men. Among the 182 patients who received a surgical procedure, gross and wide excision without radiotherapy were associated with the best OS. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Prevention and Quality of Life)
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9 pages, 1057 KiB  
Article
Reinduction of Hedgehog Inhibitors after Checkpoint Inhibition in Advanced Basal Cell Carcinoma: A Series of 12 Patients
by Viola K. DeTemple, Jessica C. Hassel, Michael M. Sachse, Imke Grimmelmann, Ulrike Leiter, Christoffer Gebhardt, Julia Eckardt, Claudia Pföhler, Yenny Angela, Hanna Hübbe and Ralf Gutzmer
Cancers 2022, 14(21), 5469; https://doi.org/10.3390/cancers14215469 - 07 Nov 2022
Cited by 1 | Viewed by 1432
Abstract
For patients with advanced basal cell carcinoma (aBCC) first-line treatment with hedgehog inhibitors (HHIs) and second-line treatment with PD1 inhibitors (PD1i) is available, offering combination and sequencing options. Here, we focus on the efficacy and safety of HHI reinduction after PD1i failure. Retrospective [...] Read more.
For patients with advanced basal cell carcinoma (aBCC) first-line treatment with hedgehog inhibitors (HHIs) and second-line treatment with PD1 inhibitors (PD1i) is available, offering combination and sequencing options. Here, we focus on the efficacy and safety of HHI reinduction after PD1i failure. Retrospective data analysis was performed with 12 patients with aBCC (locally advanced (n = 8)/metastatic (n = 4)). These patients (male:female 6:6, median age 68 years) initially received HHIs, leading to complete/partial response (66%) or stable disease (33%). Median treatment duration was 20.8 (2–64.5) months until discontinuation due to progression (n = 8), adverse events (n = 3), or patient request (n = 1). Subsequent PD1 inhibition (pembrolizumab 42%, cemiplimab 58%) yielded a partial response (8%), stable disease (33%), or progression (59%). Median treatment duration was 4.1 (0.8–16.3) months until discontinuation due to progression (n = 9), adverse events (n = 1), patient request (n = 1), or missing drug approval (n = 1). HHI reinduction resulted in complete/partial response (33%), stable disease (50%), or progression (17%). Median treatment duration was 3.6 (1–29) months. Response duration in the four responding patients was 2–29+ months. Thus, a subgroup of patients with aBCC responded to reinduction of HHI following PD1i failure. Therefore, this sequential treatment represents a feasible treatment option. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Prevention and Quality of Life)
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17 pages, 830 KiB  
Article
Using the Prediction Model Risk of Bias Assessment Tool (PROBAST) to Evaluate Melanoma Prediction Studies
by Isabelle Kaiser, Sonja Mathes, Annette B. Pfahlberg, Wolfgang Uter, Carola Berking, Markus V. Heppt, Theresa Steeb, Katharina Diehl and Olaf Gefeller
Cancers 2022, 14(12), 3033; https://doi.org/10.3390/cancers14123033 - 20 Jun 2022
Cited by 1 | Viewed by 1959
Abstract
Rising incidences of cutaneous melanoma have fueled the development of statistical models that predict individual melanoma risk. Our aim was to assess the validity of published prediction models for incident cutaneous melanoma using a standardized procedure based on PROBAST (Prediction model Risk Of [...] Read more.
Rising incidences of cutaneous melanoma have fueled the development of statistical models that predict individual melanoma risk. Our aim was to assess the validity of published prediction models for incident cutaneous melanoma using a standardized procedure based on PROBAST (Prediction model Risk Of Bias ASsessment Tool). We included studies that were identified by a recent systematic review and updated the literature search to ensure that our PROBAST rating included all relevant studies. Six reviewers assessed the risk of bias (ROB) for each study using the published “PROBAST Assessment Form” that consists of four domains and an overall ROB rating. We further examined a temporal effect regarding changes in overall and domain-specific ROB rating distributions. Altogether, 42 studies were assessed, of which the vast majority (n = 34; 81%) was rated as having high ROB. Only one study was judged as having low ROB. The main reasons for high ROB ratings were the use of hospital controls in case-control studies and the omission of any validation of prediction models. However, our temporal analysis results showed a significant reduction in the number of studies with high ROB for the domain “analysis”. Nevertheless, the evidence base of high-quality studies that can be used to draw conclusions on the prediction of incident cutaneous melanoma is currently much weaker than the high number of studies on this topic would suggest. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Prevention and Quality of Life)
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Review

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19 pages, 449 KiB  
Review
Skin Cancer Risk, Sun-Protection Knowledge and Behavior in Athletes—A Narrative Review
by Katarzyna Kliniec, Maciej Tota, Aleksandra Zalesińska, Magdalena Łyko and Alina Jankowska-Konsur
Cancers 2023, 15(13), 3281; https://doi.org/10.3390/cancers15133281 - 22 Jun 2023
Cited by 4 | Viewed by 2438
Abstract
Outdoor sports are associated with increased exposure to ultraviolet radiation, which may result in sunburn, solar damage, and skin cancers. Water and winter sports create additional adverse conditions, such as washing away sunscreen by water and reflection of UV rays by the water [...] Read more.
Outdoor sports are associated with increased exposure to ultraviolet radiation, which may result in sunburn, solar damage, and skin cancers. Water and winter sports create additional adverse conditions, such as washing away sunscreen by water and reflection of UV rays by the water and snow. Sweating-increased skin photosensitivity and activity-induced immunosuppression are associated with a greater risk of developing skin cancers. In this review, we focus on a group of athletes and sports participants and analyze 62 articles concerning sun exposure during outdoor sports, the risk of developing skin cancer, and knowledge and behavior regarding photoprotection methods. Various practices have been linked to an increased risk of developing basal cell carcinoma (BCC), squamous cell carcinoma (SCC), malignant melanoma (MM), or UV-induced skin damage. Water sports and mountaineering increase the risk of BCC. Surfing and swimming are risk factors for SCC. Melanoma is more common in swimmers, surfers, and marathon runners. Photoprotection behaviors can reduce potential skin damage and skin cancers. Athletes’ knowledge about the risk of malignant lesions was satisfactory, but despite the risks, outdoor sports participants seem not to protect themselves from the sun adequately. Full article
(This article belongs to the Special Issue Skin Cancer: Epidemiology, Prevention and Quality of Life)
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