Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
7.4
5.2
Journals
Cancers
Special Issues
Targeting Immune Checkpoints for Cancer Therapy: Potential and Challenges
share announcement

Targeting Immune Checkpoints for Cancer Therapy: Potential and Challenges

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: 15 August 2024 | Viewed by 2960

Special Issue Editors

Dr. Mona Kamal Saadeldin

E-Mail Website
Guest Editor
Department of Electrical Engineering and Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA
Interests: immunotherapy; cancer resistance; biomarker; drug discovery
Dr. Nicolò Eleonora

E-Mail Website
Guest Editor
1. Division of New Drugs and Early Drug Development for Innovative Therapies, European Institute of Oncology, IRCCS, Milan, Italy
2. Department of Oncology and Haematology (DIPO), University of Milan, Milan, Italy
3. Weill Cornell Medicine, New York, NY, USA
Interests: personalized medicine; cancer immunotherapy; drug development; liquid biopsy; breast cancer
Dr. Amal Kamal Abdel-Aziz

E-Mail Website
Guest Editor
Department of Experimental Oncology, European Institute of Oncology, Via Adamello 16, 20139 Milan, Italy
Interests: cancer resistance; toxicity; drug discovery; immunotherapy; biomarker
Dr. D’Amico Paolo

E-Mail Website
Guest Editor
Division of Hematology and Oncology, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA
Interests: immunotherapy; cancer; breast cancer; liquid biopsy; clinical trials; drug development

Special Issue Information

Dear Colleagues,

Immune checkpoint inhibitors (ICIs) are thought to have revolutionized cancer therapy. However, their clinical efficacy/potential is largely hampered by the emergence of cancer resistance and ICI-associated toxicities. The areas of interest of this Special Issue include:

  • The identification and validation of novel druggable immune checkpoints;
  • The systematic deciphering of the molecular mechanisms underlying intrinsic as well as acquired cancer resistance and toxicity to immune checkpoint inhibitors;
  • Novel biomarkers for patient selection and monitoring drug response;
  • Innovative, effective and tolerable therapeutic strategies exploiting the vulnerabilities induced in the resistant cancer subpopulation as well as exhausted immune cells to ultimately trigger synthetic lethality;
  • Literature revisions of the most recent clinical achievements, with a critical appraisal of new opportunities and upcoming challenges in the field.

This Special Issue of Cancers therefore welcomes new basic, translational and clinical research articles and timely reviews regarding all aspects of the potential and challenges of using immune checkpoint inhibitors in cancer therapy.

Dr. Mona Kamal Saadeldin
Dr. Nicolò Eleonora
Dr. Amal Kamal Abdel-Aziz
Dr. D’Amico Paolo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune checkpoint inhibitors
  • biomarkers
  • resistance
  • toxicity
  • cancer
  • drug discovery
  • therapeutic regimens

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

Jump to: Review

34 pages, 12112 KiB  
Article
Exploring the Significance of Immune Checkpoints and EBV Reactivation in Antibody Deficiencies with Near-Normal Immunoglobulin Levels or Hyperimmunoglobulinemia
by Paulina Mertowska, Sebastian Mertowski, Konrad Smolak, Marcin Pasiarski, Jolanta Smok-Kalwat, Stanisław Góźdź and Ewelina Grywalska
Cancers 2023, 15(20), 5059; https://doi.org/10.3390/cancers15205059 - 19 Oct 2023
Viewed by 772
Abstract
This study delves into the intricate landscape of primary immunodeficiencies, with a particular focus on antibody deficiencies characterized by near-normal immunoglobulin levels or hyperimmunoglobulinemia. Contrary to the conventional focus on genetic dysregulation, these studies investigate the key roles of immune checkpoints, such as [...] Read more.
This study delves into the intricate landscape of primary immunodeficiencies, with a particular focus on antibody deficiencies characterized by near-normal immunoglobulin levels or hyperimmunoglobulinemia. Contrary to the conventional focus on genetic dysregulation, these studies investigate the key roles of immune checkpoints, such as PD-1/PD-L1, CTLA-4/CD86, and CD200R/CD200, on selected subpopulations of T and B lymphocytes and their serum concentrations of soluble forms in patients recruited for the studies in healthy volunteers. In addition, the studies also show the role of Epstein–Barr virus (EBV) reactivation and interactions with tested pathways of immune checkpoints involved in the immunopathogenesis of this disease. By examining the context of antibody deficiencies, this study sheds light on the nuanced interplay of factors beyond genetics, particularly the immune dysregulations that occur in the course of this type of disease and the potential role of EBV reactivation, which affects the clinical presentation of patients and may contribute to the development of cancer in the future, especially related to hematological malignancies. Full article
(This article belongs to the Special Issue Targeting Immune Checkpoints for Cancer Therapy: Potential and Challenges)
►▼ Show Figures

Figure 1

Review

Jump to: Research

20 pages, 1271 KiB  
Review
Beyond PD(L)-1 Blockade in Microsatellite-Instable Cancers: Current Landscape of Immune Co-Inhibitory Receptor Targeting
by Edoardo Crimini, Luca Boscolo Bielo, Pier Paolo Maria Berton Giachetti, Gloria Pellizzari, Gabriele Antonarelli, Beatrice Taurelli Salimbeni, Matteo Repetto, Carmen Belli and Giuseppe Curigliano
Cancers 2024, 16(2), 281; https://doi.org/10.3390/cancers16020281 - 09 Jan 2024
Viewed by 1663
Abstract
High microsatellite instability (MSI-H) derives from genomic hypermutability due to deficient mismatch repair function. Colorectal (CRC) and endometrial cancers (EC) are the tumor types that more often present MSI-H. Anti-PD(L)-1 antibodies have been demonstrated to be agnostically effective in patients with MSI-H cancer, [...] Read more.
High microsatellite instability (MSI-H) derives from genomic hypermutability due to deficient mismatch repair function. Colorectal (CRC) and endometrial cancers (EC) are the tumor types that more often present MSI-H. Anti-PD(L)-1 antibodies have been demonstrated to be agnostically effective in patients with MSI-H cancer, but 50–60% of them do not respond to single-agent treatment, highlighting the necessity of expanding their treatment opportunities. Ipilimumab (anti-CTLA4) is the only immune checkpoint inhibitor (ICI) non-targeting PD(L)-1 that has been approved so far by the FDA for MSI-H cancer, namely, CRC in combination with nivolumab. Anti-TIM3 antibody LY3321367 showed interesting clinical activity in combination with anti-PDL-1 antibody in patients with MSI-H cancer not previously treated with anti-PD(L)-1. In contrast, no clinical evidence is available for anti-LAG3, anti-TIGIT, anti-BTLA, anti-ICOS and anti-IDO1 antibodies in MSI-H cancers, but clinical trials are ongoing. Other immunotherapeutic strategies under study for MSI-H cancers include vaccines, systemic immunomodulators, STING agonists, PKM2 activators, T-cell immunotherapy, LAIR-1 immunosuppression reversal, IL5 superagonists, oncolytic viruses and IL12 partial agonists. In conclusion, several combination therapies of ICIs and novel strategies are emerging and may revolutionize the treatment paradigm of MSI-H patients in the future. A huge effort will be necessary to find reliable immune biomarkers to personalize therapeutical decisions. Full article
(This article belongs to the Special Issue Targeting Immune Checkpoints for Cancer Therapy: Potential and Challenges)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop