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Cancers
Special Issues
Advances in Human-Papillomavirus-Related Squamous Cell Carcinoma: From Pathogenesis to Treatment
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Advances in Human-Papillomavirus-Related Squamous Cell Carcinoma: From Pathogenesis to Treatment

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Therapy".

Deadline for manuscript submissions: 20 January 2025 | Viewed by 2294

Special Issue Editors

Dr. Silvana Canevari

E-Mail Website
Guest Editor
Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Interests: cancer biology; cancer genomics; head and neck cancer; gynecological cancers
Dr. Loris De Cecco

E-Mail Website
Guest Editor
Molecular Mechanisms Unit, Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale dei Tumori, 20133 Milan, Italy
Interests: cancer biology; cancer genomics; head and neck cancer; ovary cancer; pediatric tumors
Dr. Stefano Cavalieri

E-Mail Website
Guest Editor
1. Head and Neck Medical Oncology Department, Fondazione IRCCS Istituto Nazionale dei Tumori, Via G. Venezian 1, 20133 Milan, Italy
2. Department of Oncology and Hemato-Oncology, University of Milan, Via Santa Sofia 9/1, 20122 Milan, Italy
Interests: head and neck cancer; medical oncology; clinical diagnosis; clinical treatment

Special Issue Information

Dear Colleagues,

We are pleased to invite you to this Special Issue. Based on the present knowledge, approximately 5% of the world's cancers are specifically attributed to HPV. While the greatest global burden of HPV is cervical cancers in low- and middle-income countries, HPV-associated head and neck cancers are increasing in high-income countries and have surpassed cervical cancer as the primary HPV-associated cancer in some countries. Open questions include the not well-understood mechanisms responsible for the persistence of infection, the unclear prognostic significance of HPV status in patients with head and neck squamous cell carcinomas outside of the oropharynx, the de-escalation treatments for patients with HPV+ oropharyngeal cancer, and the relationship between HPV and radiotherapy sensitivity in cervical cancer.

This Special Issue aims to contribute to an improved understanding of the molecular basis and of the clinical course of HPV-positive cancer to guide efforts towards early detection and precision care and to improve patient outcomes. In this Special Issue, original research articles and reviews are welcome.

We look forward to receiving your contributions.

Dr. Silvana Canevari
Dr. Loris De Cecco
Dr. Stefano Cavalieri
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • HPV
  • head and neck cancer
  • oropharynx
  • cervical cancer
  • genomics
  • metabolomics
  • tumor heterogeneity
  • microenvironment
  • biomarkers
  • epidemiology and vaccine

Published Papers (2 papers)

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Review

13 pages, 990 KiB  
Review
A Comprehensive Review of Genistein’s Effects in Preclinical Models of Cervical Cancer
by Matteo Nadile, Amanda Kornel, Newman Siu Kwan Sze and Evangelia Tsiani
Cancers 2024, 16(1), 35; https://doi.org/10.3390/cancers16010035 - 20 Dec 2023
Cited by 1 | Viewed by 876
Abstract
Cervical cancer is associated with persistent Human Papilloma Virus (HPV) infections and is the fourth most common cancer in women worldwide. Current treatment options; surgery, chemotherapy, and radiation, are often associated with severe side effects including possible infertility. Novel treatment options are required [...] Read more.
Cervical cancer is associated with persistent Human Papilloma Virus (HPV) infections and is the fourth most common cancer in women worldwide. Current treatment options; surgery, chemotherapy, and radiation, are often associated with severe side effects including possible infertility. Novel treatment options are required to help combat this disease and reduce side effects. Many plant-derived chemicals, including paclitaxel and docetaxel, are already in use as treatments for various cancers. Genistein is a polyphenolic isoflavone found in foods including soybeans and legumes, and studies have shown that it has various biological effects and anti-cancer properties. This review aims to summarize the existing studies examining the effects of genistein on cervical cancer. All relevant in vitro and in vivo studies are summarized, and the key findings are highlighted in the associated tables. Based on the available in vitro/cell culture studies reported here, genistein inhibits cervical cancer cell proliferation and induces apoptosis. Use of genistein in combination with radiation or chemotherapy agents resulted in enhanced response indicating radio- and chemo-sensitization properties. More animal studies are required to examine the effectiveness of genistein in vivo. Such studies will form the basis for future human studies exploring the potential of genistein to be used in the treatment of cervical cancer. Full article
(This article belongs to the Special Issue Advances in Human-Papillomavirus-Related Squamous Cell Carcinoma: From Pathogenesis to Treatment)
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31 pages, 2018 KiB  
Review
Epigenetic and Genetic Keys to Fight HPV-Related Cancers
by Veronica Folliero, Federica Dell’Annunziata, Annalisa Chianese, Maria Vittoria Morone, Francesca Mensitieri, Federica Di Spirito, Antonio Mollo, Massimo Amato, Massimiliano Galdiero, Fabrizio Dal Piaz, Pasquale Pagliano, Luca Rinaldi and Gianluigi Franci
Cancers 2023, 15(23), 5583; https://doi.org/10.3390/cancers15235583 - 25 Nov 2023
Cited by 1 | Viewed by 1063
Abstract
Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving [...] Read more.
Cervical cancer ranks as the fourth most prevalent cancer among women globally, with approximately 600,000 new cases being diagnosed each year. The principal driver of cervical cancer is the human papillomavirus (HPV), where viral oncoproteins E6 and E7 undertake the role of driving its carcinogenic potential. Despite extensive investigative efforts, numerous facets concerning HPV infection, replication, and pathogenesis remain shrouded in uncertainty. The virus operates through a variety of epigenetic mechanisms, and the epigenetic signature of HPV-related tumors is a major bottleneck in our understanding of the disease. Recent investigations have unveiled the capacity of viral oncoproteins to influence epigenetic changes within HPV-related tumors, and conversely, these tumors exert an influence on the surrounding epigenetic landscape. Given the escalating occurrence of HPV-triggered tumors and the deficiency of efficacious treatments, substantial challenges emerge. A promising avenue to address this challenge lies in epigenetic modulators. This review aggregates and dissects potential epigenetic modulators capable of combatting HPV-associated infections and diseases. By delving into these modulators, novel avenues for therapeutic interventions against HPV-linked cancers have come to the fore. Full article
(This article belongs to the Special Issue Advances in Human-Papillomavirus-Related Squamous Cell Carcinoma: From Pathogenesis to Treatment)
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