Biomaterials for Cancer Immunotherapy 2.0

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Immunology and Immunotherapy".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 1485

Special Issue Editor


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Guest Editor
Professor and Dean, Temple University School of Pharmacy, 3307 North Broad Street, Philadelphia, PA 19140, USA
Interests: targeted drug delivery; nanoparticles; antibody-drug conjugates; controlled release; chemoprevention; immunotherapy; cancer vaccine
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Special Issue Information

Dear Colleagues, 

This Special Issue is the second edition of the previous one, "Biomaterials for Cancer Immunotherapy" https://www.mdpi.com/journal/cancers/special_issues/Biomaterials_Cancer_Immunotherapy.

The goal of cancer immunotherapy is to activate the host immune system to recognize and eliminate malignant cells. The term immunotherapy is used broadly to include various vaccine modalities, cytokines, CAR-T cells, NK cell therapies, antibodies that mediate antibody-dependent cellular cytotoxicity, checkpoint inhibitors, oncolytic viruses, and immunomodulators that reverse tumor-induced immunosuppression. Immunotherapy is highly effective in improving therapeutic outcomes in many tumor types, including melanoma, renal cell carcinoma, bladder cancer, head and neck cancers, and lung cancers. However, only a subset of patients benefit from it, and resistance can develop even in those patients. Further, some immunotherapeutic modalities are associated with serious side effects. There is intense interest in further improving the effectiveness of immunotherapy and overcoming resistance.

Biomaterials can improve the effectiveness of immunotherapy by facilitating selective and improved delivery of the active agent to the target cells and tissue. The enhanced activation of antigen-presenting cells by delivering immunostimulants in nanocarriers and the improved activity of checkpoint inhibitors following local sustained delivery are some examples. The goal of this Special Issue on “Biomaterials for Cancer Immunotherapy 2.0” is to further highlight, through original research articles as well as comprehensive reviews, the use of biomaterials to improve the safety and efficacy of anticancer immunotherapy.

Prof. Dr. Jayanth Panyam
Guest Editor

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • vaccines
  • immunomodulators
  • antibodies
  • checkpoint inhibitors
  • immunosuppression
  • cell therapy

Published Papers (1 paper)

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Research

23 pages, 17110 KiB  
Article
Comprehensive Immune Profiling Unveils a Subset of Leiomyosarcoma with “Hot” Tumor Immune Microenvironment
by Xiaolan Feng, Laurie Tonon, Haocheng Li, Elodie Darbo, Erin Pleasance, Nicolas Macagno, Armelle Dufresne, Mehdi Brahmi, Julien Bollard, Francoise Ducimetière, Marie Karanian, Alexandra Meurgey, Gaëlle Pérot, Thibaud Valentin, Frédéric Chibon and Jean-Yves Blay
Cancers 2023, 15(14), 3705; https://doi.org/10.3390/cancers15143705 - 21 Jul 2023
Cited by 2 | Viewed by 1197
Abstract
Purpose: To investigate the immune biomarker in Leiomyosarcoma (LMS), which is rare and recognized as an immune cold cancer showing a poor response rate (<10%) to immune checkpoint inhibitors (ICIs). However, durable response and clinical benefit to ICIs has been observed in a [...] Read more.
Purpose: To investigate the immune biomarker in Leiomyosarcoma (LMS), which is rare and recognized as an immune cold cancer showing a poor response rate (<10%) to immune checkpoint inhibitors (ICIs). However, durable response and clinical benefit to ICIs has been observed in a few cases of LMS, including, but not only, LMS with tertiary lymphoid structure (TLS) structures. Patients and methods: We used comprehensive transcriptomic profiling and a deconvolution method extracted from RNA-sequencing gene expression data in two independent LMS cohorts, the International Cancer Genome Consortium (ICGC, N = 146) and The Cancer Genome Atlas (TCGA, N = 75), to explore tumor immune microenvironment (TIME) in LMS. Results: Unsupervised clustering analysis using the previously validated two methods, 90-gene signature and Cell-type Identification by Estimating Relative Subsets of RNA Transcripts (CIBERSORT), identified immune hot (I-H) and immune high (I-Hi) LMS, respectively, in the ICGC cohort. Similarly, immune active groups (T-H, T-Hi) were identified in the TCGA cohort using these two methods. These immune active (“hot”) clusters were significantly associated, but not completely overlapping, with several validated immune signatures such as sarcoma immune class (SIC) classification and TLS score, T cell inflamed signature (TIS) score, immune infiltration score (IIS), and macrophage score (M1/M2), with more patients identified by our clustering as potentially immune hot. Conclusions: Comprehensive immune profiling revealed a subset of LMS with a distinct active (“hot”) TIME, consistently associated with several validated immune signatures in other cancers. This suggests that the methodologies that we used in this study warrant further validation and development, which can potentially help refine our current immune biomarkers to select the right LMS patients for ICIs in clinical trials. Full article
(This article belongs to the Special Issue Biomaterials for Cancer Immunotherapy 2.0)
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