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Cancers
Special Issues
Early Detection and Surgery for Pancreatic Cancer
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Early Detection and Surgery for Pancreatic Cancer

A special issue of Cancers (ISSN 2072-6694). This special issue belongs to the section "Cancer Causes, Screening and Diagnosis".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 2533

Special Issue Editors

Dr. Laleh Melstrom

E-Mail Website
Guest Editor
Department of Surgery, City of Hope National Medical Center, Duarte, CA 91010, USA
Interests: RNA methylation; pancreatic cancer novel therapy; patient-generated health data
Dr. Vincent Chung

E-Mail Website
Guest Editor
Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA 91010, USA
Interests: pancreatic cancer; phase I trials
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In the past 10 years, the average 5-year survival for pancreatic cancer has increased from 5% to 11%.  The lack of early detection and optimal therapy remain as consistent challenges. In this Special Issue, we aim to highlight work being carried out on the early biology of pancreatic cancer development, challenges in diagnosis, and advancements in treatment of early disease. We are pleased to invite you to contribute your work in the form of original research, meta analyses, or reviews.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: pancreatic cancer initiation, detection challenges, and surgical advances.

We look forward to receiving your contributions.

Dr. Laleh Melstrom
Dr. Vincent Chung
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cancers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • molecular mechanisms
  • diagnostic testing
  • endoscopic ultrasound
  • minimally invasive surgery
  • pancreatic cancer

Published Papers (2 papers)

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Research

13 pages, 3465 KiB  
Article
Pancreatic Cyst Size Measurement on Magnetic Resonance Imaging Compared to Pathology
by Daniel Jeong, Brian Morse, Stuart Lane Polk, Dung-Tsa Chen, Jiannong Li, Pamela Hodul, Barbara A. Centeno, James Costello, Kun Jiang, Sebastian Machado, Issam El Naqa, Paola T. Farah, Tri Huynh, Natarajan Raghunand, Shaffer Mok, Aamir Dam, Mokenge Malafa, Aliya Qayyum, Jason B. Fleming and Jennifer B. Permuth
Cancers 2024, 16(1), 206; https://doi.org/10.3390/cancers16010206 - 01 Jan 2024
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Abstract
BACKGROUND: While multiple cyst features are evaluated for stratifying pancreatic intraductal papillary mucinous neoplasms (IPMN), cyst size is an important factor that can influence treatment strategies. When magnetic resonance imaging (MRI) is used to evaluate IPMNs, no universally accepted sequence provides optimal size [...] Read more.
BACKGROUND: While multiple cyst features are evaluated for stratifying pancreatic intraductal papillary mucinous neoplasms (IPMN), cyst size is an important factor that can influence treatment strategies. When magnetic resonance imaging (MRI) is used to evaluate IPMNs, no universally accepted sequence provides optimal size measurements. T2-weighted coronal/axial have been suggested as primary measurement sequences; however, it remains unknown how well these and maximum all-sequence diameter measurements correlate with pathology size. This study aims to compare agreement and bias between IPMN long-axis measurements on seven commonly obtained MRI sequences with pathologic size measurements. METHODS: This retrospective cohort included surgically resected IPMN cases with preoperative MRI exams. Long-axis diameter tumor measurements and the presence of worrisome features and/orhigh-risk stigmata were noted on all seven MRI sequences. MRI size and pathology agreement and MRI inter-observer agreement involved concordance correlation coefficient (CCC) and intraclass correlation coefficient (ICC), respectively. The presence of worrisome features and high-risk stigmata were compared to the tumor grade using kappa analysis. The Bland-Altman analysis assessed the systematic bias between MRI-size and pathology. RESULTS: In 52 patients (age 68 ± 13 years, 22 males), MRI sequences produced mean long-axis tumor measurements from 2.45–2.65 cm. The maximum MRI lesion size had a strong agreement with pathology (CCC = 0.82 (95% CI: 0.71–0.89)). The maximum IPMN size was typically observed on the axial T1 arterial post-contrast and MRCP coronal series and overestimated size versus pathology with bias +0.34 cm. The radiologist interobserver agreement reached ICCs 0.74 to 0.91 on the MRI sequences. CONCLUSION: The maximum MRI IPMN size strongly correlated with but tended to overestimate the length compared to the pathology, potentially related to formalin tissue shrinkage during tissue processing. Full article
(This article belongs to the Special Issue Early Detection and Surgery for Pancreatic Cancer)
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12 pages, 1480 KiB  
Article
Assessment of the Psychosocial Impact of Pancreatic Cancer Surveillance in High-Risk Individuals
by Isabel Anez-Bruzual, Sarah Coughlin, Daniel Clay, Jordan Heiman, Michaela Dungan, Marina Weber, Christopher V. Almario, Galen Leung, Nuzhat A. Ahmad, Gregory G. Ginsberg, Michael L. Kochman, Kathleen D. Valverde, Jessica M. Long and Bryson W. Katona
Cancers 2024, 16(1), 86; https://doi.org/10.3390/cancers16010086 - 23 Dec 2023
Viewed by 783
Abstract
Objectives: Pancreatic cancer (PC) surveillance of high-risk individuals (HRIs) downstages PC and improves survival. However, it remains less clear whether PC surveillance has a positive psychosocial impact on HRIs. Herein, we aimed to define the attitudes and beliefs of HRIs undergoing PC surveillance, [...] Read more.
Objectives: Pancreatic cancer (PC) surveillance of high-risk individuals (HRIs) downstages PC and improves survival. However, it remains less clear whether PC surveillance has a positive psychosocial impact on HRIs. Herein, we aimed to define the attitudes and beliefs of HRIs undergoing PC surveillance, and the immediate and sustained psychosocial impact of PC surveillance in HRIs. Methods: 100 HRIs undergoing PC surveillance by endoscopic ultrasound (EUS) completed three surveys addressing different components of the psychosocial impact of PC surveillance. Logistic regression analyses were performed to identify predictive factors relating to these components. Results: Most HRIs reported increased perceived benefits of PC surveillance, self-efficacy, and perceived severity of PC. HRIs reported few negative emotions prior to surveillance and frequent positive emotions after surveillance. Compared to prior to surveillance, there was a 53.5% decrease in the level of distress reported by HRIs after surveillance, which was sustained for 4–6 weeks post-surveillance. Family history of PC and lower self-reported mental health were identified as predictors for increased perceived susceptibility to PC (p < 0.01) and greater change in distress pre- to post-surveillance (p < 0.01), respectively. Conclusions: Our findings suggest that PC surveillance can lead to sustained psychosocial benefits in HRIs. Full article
(This article belongs to the Special Issue Early Detection and Surgery for Pancreatic Cancer)
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